ChemicalBook >> CAS DataBase List >>EMPA
EMPA
- CAS No.
- 680590-49-2
- Chemical Name:
- EMPA
- Synonyms
- EMPA, CID 9981404;Hypocretin Receptor,EMPA,Orexin Receptor (OX Receptor),HCRT Receptor,inhibit,Inhibitor;N-ETHYL-2-[(6-METHOXYPYRIDIN-3-YL)-(2-METHYLPHENYL)SULFONYLAMINO]-N-(PYRIDIN-3-YLMETHYL)ACETAMIDE;N-Ethyl-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinylmethyl)-acetamide;Acetamide, N-ethyl-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinylmethyl)-
- CBNumber:
- CB32695845
- Molecular Formula:
- C23H26N4O4S
- Molecular Weight:
- 454.54
- MDL Number:
- MOL File:
- 680590-49-2.mol
Last updated:2023-09-04 16:42:00
Boiling point | 660.7±65.0 °C(Predicted) |
---|---|
Density | 1.280±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
form | Powder |
pka | 4.77±0.10(Predicted) |
color | white to light brown |
FDA UNII | VT87V86D7W |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
Hazard Codes | Xn | |||||||||
Risk Statements | 22 | |||||||||
WGK Germany | 3 | |||||||||
NFPA 704 |
|
EMPA price More Price(12)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML0864 | EMPA ≥98% (HPLC) | 680590-49-2 | 5mg | $132 | 2024-03-01 | Buy |
Sigma-Aldrich | SML0864 | EMPA ≥98% (HPLC) | 680590-49-2 | 25mg | $430 | 2024-03-01 | Buy |
Cayman Chemical | 29446 | EMPA | 680590-49-2 | 5mg | $117 | 2024-03-01 | Buy |
Cayman Chemical | 29446 | EMPA | 680590-49-2 | 10mg | $186 | 2024-03-01 | Buy |
TRC | E521550 | EMPA | 680590-49-2 | 100mg | $1210 | 2021-12-16 | Buy |
EMPA Chemical Properties,Uses,Production
Description
EMPA is an orexin 2 receptor (OX2R) antagonist (Ki = 1.1 nM). It is selective for OX2R over OX1R (Ki = 900 nM). EMPA inhibits orexin-A- and orexin-B-induced calcium mobilization (IC50s = 8.8 and 7.9 nM, respectively) and increases orexin-A- and orexin-B-induced inositol phosphate accumulation (EC50s = 1.1 and 2.4 nM, respectively) in CHO(dHFr-) cells expressing recombinant human OX2R. It reduces spontaneous locomotor activity and orexin-B-induced hyperlocomotion in mice when administered at doses ranging between 10 and 300 mg/kg.
Uses
EMPA is a novel high-affinity, selective antagonist for the OX2 receptor.
storage
Store at -20°C
EMPA Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 40)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8072 | 58 |
ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 | info@yuhaochemical.com | China | 2031 | 58 |
Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696,15000506266 15000506266 | China | 4287 | 55 | |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
680590-49-2(EMPA)Related Search:
N-Ethyl-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinylmethyl)-acetamide
N-ETHYL-2-[(6-METHOXYPYRIDIN-3-YL)-(2-METHYLPHENYL)SULFONYLAMINO]-N-(PYRIDIN-3-YLMETHYL)ACETAMIDE
EMPA, CID 9981404
Acetamide, N-ethyl-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinylmethyl)-
Hypocretin Receptor,EMPA,Orexin Receptor (OX Receptor),HCRT Receptor,inhibit,Inhibitor
680590-49-2
Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds