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SQ 22,536

SQ 22,536 Structure
SQ 22,536 structure
CAS No.
17318-31-9
Chemical Name:
SQ 22,536
Synonyms
Ax 100;CS-2551;Nsc 53339;9-THF-Ade;SQ 22,536;SQ 22536;SQ-22536;SQ22,536/Inhibitor;SQ22536 (NSC-53339);9-(Tetrahydrofuran-2-yl);Tetrahydrofuryl-9-adenine
CBNumber:
CB3289950
Molecular Formula:
C9H11N5O
Molecular Weight:
205.22
MDL Number:
MFCD00210216
MOL File:
17318-31-9.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33
Request For Quotation

SQ 22,536 Properties

Melting point 160-161℃
Boiling point 474.8±55.0 °C(Predicted)
Density 1.70±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility H2O: 21 mg/mL
form solid
pka 3.82±0.10(Predicted)
color white to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
HS Code  2934.99.9001
NFPA 704
0
2 0

SQ 22,536 price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S153 SQ 22,536 ≥97% (HPLC), powder 17318-31-9 5mg $220 2024-03-01 Buy
Sigma-Aldrich 568500 SQ 22536 Cell-permeable adenylate cyclase inhibitor. 17318-31-9 5mg $187 2024-03-01 Buy
TCI Chemical Q0105 SQ 22536 17318-31-9 10MG $156 2024-03-01 Buy
TCI Chemical Q0105 SQ 22536 17318-31-9 50MG $560 2024-03-01 Buy
Alfa Aesar J67455 SQ 22536 95% 17318-31-9 5mg $136 2023-06-20 Buy
Product number Packaging Price Buy
S153 5mg $220 Buy
568500 5mg $187 Buy
Q0105 10MG $156 Buy
Q0105 50MG $560 Buy
J67455 5mg $136 Buy

SQ 22,536 Chemical Properties,Uses,Production

Description

SQ 22,536 is an inhibitor of adenylyl cyclase with an IC50 value of 13 μM for inhibition of prostaglandin E1-stimulated increase in cAMP in intact platelets. It has been used to evaluate adenylyl cyclase activity during iloprost-induced vasorelaxation of isolated pulmonary veins or aorta in several research paradigms, inhibiting cAMP elevation at concentrations of 100-300 μM without effecting relaxation.

Uses

SQ 22,536 was used to study the role of adenylate cyclase in differentiation of PC12 cells and in gap junctional intercellular communication in breast cancer cells.

Definition

ChEBI: A nucleoside analogue that is adenine in which the nitrogen at position 9 has been substituted by a tetrahydrofuran-2-yl group. It is an adenylate cyclase inhibitor.

Biological Activity

Inhibitor of adenylyl cyclase (IC 50 = 1.4 μ M). Inhibits PGE 1 -stimulated increases in cAMP levels in intact human platelets.

Biochem/physiol Actions

SQ 22,536 is an effective inhibitor of not only basal but also prosptaglandin E1-activated adenylate cyclase activities in platelets.1 It reverses hyperalgesia contralaterally and ipsilaterally when injected intramuscularly in rats.2

storage

Store at +4°C

SQ 22,536 Preparation Products And Raw materials

Raw materials

Preparation Products

SQ 22,536 Suppliers

Global( 124)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29791 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32956 60
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
Labnetwork lnc. 		+86-27-50766799 +8618062016861 contact@labnetwork.com China 19987 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Nanjing Doge Biomedical Technology Co., Ltd 		+86-25-58227606 +86-15305155328 sales@dogechemical.com China 4128 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24727 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
Alchem Pharmtech,Inc. 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Labnetwork lnc. 		58
InvivoChem 		58
Nanjing Doge Biomedical Technology Co., Ltd 		58
LEAP CHEM CO., LTD. 		58

View Lastest Price from SQ 22,536 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SQ22536 pictures 2024-11-19 SQ22536
17318-31-9
 US $47.00-163.00 / mg 98.8% 10g TargetMol Chemicals Inc.
  • SQ22536 pictures
  • SQ22536
    17318-31-9
  • US $47.00-163.00 / mg
  • 98.8%
  • TargetMol Chemicals Inc.

SQ 22,536 Spectrum

SQ 22,536(17318-31-9)1HNMR

17318-31-9(SQ 22,536)Related Search:

Cyclic AMP 5'-IODO-5'-DEOXYADENOSINE ADENOSINE-2':3'-CYCLIC MONOPHOSPHATE, SODIUM SALT 2'-Deoxyadenosine monohydrate 8-BROMOADENOSINE
3'-ADENYLIC ACID N6-ISOPENTENYLADENOSINE-D6 2',3'-O-Isopropylideneadenosine 5'-Tosyladenosine 2-Chloroadenosine
2'-Deoxyadenosine 5'-phosphate Vidarabine Adenosine 5'-monophosphate monohydrate Bucladesine sodium N6-BENZYLADENOSINE
N6-Benzoyl-2'-deoxyadenosine 6-METHYLAMINOPURINE 9-RIBOFURANOSIDE 5'-ACETYL-2',3'-ISOPROPYLIDENEADENOSINE

1of4

9-(2-tetrahydrofuryl)adenine SQ 22,536 ADENYLATE CYCLASE INH 9-(Tetrahydro-2-furynal)-9H-purin-6-amine SQ22,536/Inhibitor 9-(Tetrahydro-2-furanyl)-9H-purin-6-amine, 9-THF-Ade 6-Amino-9-[(tetrahydrofuran)-2-yl]-9H-purine 9-(Tetrahydrofuran-2-yl)-9H-purine-6-amine 6-Amino-9-(tetrahydro-2-furyl)-9H-purine 9-(Tetrahydrofuryl)adenine 9H-Purin-6-amine, 9-(tetrahydro-2-furanyl)- (9ci) Adenine, 9-(tetrahydro-2-furanyl)- (8ci) Adenine, 9-(tetrahydro-2-furyl)- Ax 100 Nsc 53339 9-(Tetrahydrofuran-2-yl)-9H-purin-6-aMine 9H-Purin-6-aMine, 9-(tetrahydro-2-furanyl)- 9-THF-Ade 9-(Tetrahydrofuran-2-yl) SQ 22,536 9-(oxolan-2-yl)-9H-purin-6-amine 9-(TETRAHYDRO-2-FURANYL)-9H-PURIN-6-AMINE 9-(TETRAHYDRO-2-FURANYL)-9H-PURINE-6-AMINE 9-(TETRAHYDRO-2'-FURYL)ADENINE 9-(oxolan-2-yl)purin-6-amine 9-THF-ADE;9-(TETRAHYDROFURAN-2-YL)-9H-PURIN-6-AMINE SQ 22536 - CAS 17318-31-9 - Calbiochem CS-2551 SQ 22536;SQ-22536 Tetrahydrofuryl-9-adenine SQ22536 (NSC-53339) 9-(Tetrahydro-furan-2-yl)-9H-purin-6-ylamine SQ 22536, Non-competitive adenylyl cyclase inhibitor 17318-31-9 C9H22N5O C9H11N5O G Proteins and Cyclic Nucleotides Cyclic Nucleotide Metabolism Adenylyl Cyclase Inhibitors BioChemical Cell Biology Cell Signaling and Neuroscience