ChemicalBook >> CAS DataBase List >>UNC2170 Maleate
UNC2170 Maleate
- CAS No.
- 1648707-58-7
- Chemical Name:
- UNC2170 Maleate
- Synonyms
- UNC-2170;UNC-2170 HCl;UNC2170 Maleate;UNC2170 trifluoroacetate;3-Bromo-N-(3-(tert-butylamino)propyl)benzamide;Benzamide, 3-bromo-N-[3-[(1,1-dimethylethyl)amino]propyl]-;UNC-2170,UNC2170,Kme readers,tudor domain,UNC 2170,H4K20me2,ligand,53BP1,inhibit,double-strand DNA breaks,Inhibitor
- CBNumber:
- CB33067588
- Molecular Formula:
- C14H21BrN2O
- Molecular Weight:
- 313.23
- MDL Number:
- MFCD29770818
- MOL File:
- 1648707-58-7.mol
Last updated:2023-09-04 15:51:00
| Boiling point | 419.6±30.0 °C(Predicted) |
|---|---|
| Density | 1.233±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 40 mg/ml) or in Water (up to 50 mg/ml). |
| form | solid |
| pka | 14.63±0.46(Predicted) |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
UNC2170 Maleate price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17374 | UNC2170 (maleate) ≥95% | 1648707-58-7 | 1mg | $42 | 2022-04-27 | Buy |
| Cayman Chemical | 17374 | UNC2170 (maleate) ≥95% | 1648707-58-7 | 5mg | $165 | 2022-04-27 | Buy |
| Cayman Chemical | 17374 | UNC2170 (maleate) ≥95% | 1648707-58-7 | 10mg | $309 | 2022-04-27 | Buy |
| Cayman Chemical | 17374 | UNC2170 (maleate) ≥95% | 1648707-58-7 | 25mg | $668 | 2022-04-27 | Buy |
| AK Scientific | SYN5678 | UNC2170maleate | 1648707-58-7 | 50mg | $1052 | 2021-12-16 | Buy |
UNC2170 Maleate Chemical Properties,Uses,Production
Description
UNC-2170 (1648707-58-7), identified by screening, was found to be a μM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170 functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.1
References
1) Perfetti?et al.?(2015),?Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein 53BP1; ACS Chem. Biol.,?10?1072
UNC2170 Maleate Preparation Products And Raw materials
Raw materials
Preparation Products
UNC2170 Maleate Suppliers
Global( 40)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | 1014988033@qq.com | China | 4981 | 55 |
| Dezhou LonWel Pharmaceutical Technology Co., Ltd. | 13761310616 | 39324283@qq.com | China | 1989 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
1648707-58-7(UNC2170 Maleate)Related Search:
UNC2170 trifluoroacetate
UNC2170 Maleate
UNC-2170
Benzamide, 3-bromo-N-[3-[(1,1-dimethylethyl)amino]propyl]-
3-Bromo-N-(3-(tert-butylamino)propyl)benzamide
UNC-2170 HCl
UNC-2170,UNC2170,Kme readers,tudor domain,UNC 2170,H4K20me2,ligand,53BP1,inhibit,double-strand DNA breaks,Inhibitor
1648707-58-7