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Plecanatide

Plecanatide structure

CAS No.: 467426-54-6

Chemical Name:: Plecanatide

Synonyms: Trulance;ATCH(1-39);Pukanatide;Plecanatide;Prikanatide;Plecanatidee;Pucanapeptide;Plecanatide impurity;Plecanatide USP/EP/BP;Plecanatide Impurtiy

CBNumber:: CB33164713

Molecular Formula:: C65H104N18O26S4

Molecular Weight:: 1681.89

MDL Number:: MFCD33029246

MOL File:: 467426-54-6.mol

Last updated:2025-04-17 18:22:24

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Plecanatide Properties

Boiling point	2120.0±65.0 °C(Predicted)
Density	1.47±0.1 g/cm3(Predicted)
pka	3.61±0.21(Predicted)
form	Solid
color	White to off-white
InChIKey	NSPHQWLKCGGCQR-DLJDZFDSSA-N
FDA UNII	7IK8Z952OK
ATC code	A06AX07

SAFETY

Risk and Safety Statements

Hazardous Substances Data	467426-54-6(Hazardous Substances Data)

Plecanatide Chemical Properties,Uses,Production

Uses

Plecanatide is used in the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation. It works as a laxative by drawing water in to the gastrointestinal tract thereby softening stool and encouraging its natural passage.

Enzyme inhibitor

This uroguanylin analogue (FW = 1681.90 g/mol; CAS 467426-54-6), also known by the codename SP-304, binds to and activates guanylate cyclase-C (GC-C) receptors (EC50 ≈ 0.3 μM) expressed on the epithelial cells lining turn sequentially activates protein kinase G-II and the chloride channel known as the Cystic Fibrosis Transmembrane-conductance Regulator (CFTR) to regulate ion and fluid transport, to promote epithelial cell homeostasis, and to maintain barrier function in the GI mucosa. Plecanatide is a hexadecapeptide that is structurally identical to uroguanylin, except for an glutamate substitution at position-3. Oral treatment with plecanatide at a dose range between 0.05-2.5 mg/kg per day is as effective as once-daily treatment with 5-amino salicylic acid (100 mg/kg) or sulfasalazine (80 mg/kg). Amelioration of colitis by the treatment with plecanatide or dolcanatide was not dose-dependent, most likely due to saturation of available GC-C receptors.

in vivo

Plecanatide (0.5 and 2.5 mg/kg, p.o.) ameliorates spontaneous and chemically induced colitis after treatment for 7 days in BALB/c mice, and 14 days in TCRα^-/- mice^[1].
Plecanatide (0.005-5 mg/kg, once daily for 7 days) also shows anti-inflammatory activity in dextran sulfate sodium (DSS) and trinitrobenzene sulfonic (TNBS)-induced colitis in BDF-1 mice^[1].

Animal Model:	Female BALB/c mice (2-4 month old) are induced colitis by TNBS^[1]
Dosage:	0, 0.5 and 2.5 mg/kg
Administration:	P.o. for 7 days
Result:	Effectively reduced colitis severity scores as compared to vehicle treatment.

Plecanatide Preparation Products And Raw materials

Raw materials

Preparation Products

Plecanatide Suppliers

Global( 194)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15383	58
Apextide Co Ltd	+86-15300650552 +86-15300650552	info@apextide.com	China	92	58
Shanghai Yunao International Trade Co., Ltd	+8617621705551	asdf@shanghaihg.cn	China	264	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	10983	58
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	admin@guyunchem.com	China	615	58
Shanghai Getian Industrial Co., LTD	+86-15373193816 +86-15373193816	mike@ge-tian.com	China	269	58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	+86-18600796368 +86-18600796368	sales@sjar-tech.com	China	485	58
Shandong Huizhihan Supply Chain Co., Ltd	+86-13363081709 +86-13363000288	3957328362@qq.com	China	300	58
Adachibio Inc.	+8108027837258	sales@adachi-bio.com	China	992	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29730	60

Supplier	Advantage
AFINE CHEMICALS LIMITED	58
Apextide Co Ltd	58
Shanghai Yunao International Trade Co., Ltd	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Nantong Guangyuan Chemicl Co,Ltd	58
Shanghai Getian Industrial Co., LTD	58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	58
Shandong Huizhihan Supply Chain Co., Ltd	58
Adachibio Inc.	58
Capot Chemical Co.,Ltd.	60

View Lastest Price from Plecanatide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-22	Plecanatide 467426-54-6	US $75.00-750.00 / kg	10kg	0.99	20tons	Zibo Hangyu Biotechnology Development Co., Ltd
2025-02-17	Plecanatide 467426-54-6	US $0.00-0.00 / BOX	1BOX	99.99%	1000	Shandong Huizhihan Supply Chain Co., Ltd
2025-02-17	Plecanatide 467426-54-6	US $0.00-0.00 / BOX	1BOX	99%	2000	Shandong Huizhihan Supply Chain Co., Ltd

Plecanatide
467426-54-6
US $75.00-750.00 / kg
0.99
Zibo Hangyu Biotechnology Development Co., Ltd

Plecanatide
467426-54-6
US $0.00-0.00 / BOX
99.99%
Shandong Huizhihan Supply Chain Co., Ltd

Plecanatide
467426-54-6
US $0.00-0.00 / BOX
99%
Shandong Huizhihan Supply Chain Co., Ltd

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Plecanatide ASN-ASP-GLU-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU(DISULFIDE BOND CYS1&CYS3,CYS2&CYS4) Plecanatide Impurtiy L-Leucine, L-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4→12),(7→15)-bis(disulfide) Plecanatide impurity Plecanatide USP/EP/BP Prikanatide ATCH(1-39) Trulance (4S)-4-[(2S)-2-[(2S)-2-amino-3-carbamoylpropanamido]-3-carboxypropanamido]-4-{[(1R,4S,7S,10S,13S,16R,19S,22S,25R,32S,38R)-10-(carbamoylmethyl)-38-{[(1S)-1-carboxy-3-methylbutyl]carbamoyl}-22-(2-carboxyethyl)-32-[(1R)-1-hydroxyethyl]-4-methyl-19-(2-methylpropyl)-3,6,9,12,15,18,21,24,30,33,36-undecaoxo-7,13-bis(propan-2-yl)-27,28,40,41-tetrathia-2,5,8,11,14,17,20,23,31,34,37-undecaazabicyclo[14.13.13]dotetracontan-25-yl]carbamoyl}butanoic acid Pukanatide (S)-5-(((1R,4S,7S,10S,13S,16R,19S,22S,25R,32S,38R)-10-(2-Amino-2-oxoethyl)-38-(((S)-1-carboxy-3-methylbutyl)carbamoyl)-22-(2-carboxyethyl)-32-((R)-1-hydroxyethyl)-19-isobutyl-7,13-diisopropyl-4-methyl-3,6,9,12,15,18,21,24,30,33,36-undecaoxo-27,28,40,41-tetrathia-2,5,8,11,14,17,20,23,31,34,37-undecaazabicyclo[14.13.13]dotetracontan-25-yl)amino)-4-((S)-3-carboxy-2-((S)-2,4-diamino-4-oxobutanamido)propanamido)-5-oxopentanoic acid Plecanatidee Pucanapeptide (2S)-2-[[(1R,4S,7S,10S,13S,16R,19S,22S,25R,32S,38R)-10-(2-amino-2-oxoethyl)-25-[[(2S)-4-carboxy-2-[[(2S)-3-carboxy-2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]propanoyl]amino]butanoyl]amino]-22-(2-carboxyethyl)-32-[(1R)-1-hydroxyethyl]-4-methyl-19-(2-methylpropyl)-3,6,9,12,15,18,21,24,30,33,36-undecaoxo-7,13-di(propan-2-yl)-27,28,40,41-tetrathia-2,5,8,11,14,17,20,23,31,34,37-undecazabicyclo[14.13.13]dotetracontane-38-carbonyl]amino]-4-methylpentanoic acid 467426-54-6 C65H104N18O26S4