Plecanatide
- CAS No.
- 467426-54-6
- Chemical Name:
- Plecanatide
- Synonyms
- Trulance;ATCH(1-39);Pukanatide;Plecanatide;Prikanatide;Plecanatide impurity;Plecanatide USP/EP/BP;Plecanatide Impurtiy;ASN-ASP-GLU-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU(DISULFIDE BOND CYS1&CYS3,CYS2&CYS4);L-Leucine, L-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4→12),(7→15)-bis(disulfide)
- CBNumber:
- CB33164713
- Molecular Formula:
- C65H104N18O26S4
- Molecular Weight:
- 1681.89
- MDL Number:
- MFCD33029246
- MOL File:
- 467426-54-6.mol
Boiling point | 2120.0±65.0 °C(Predicted) |
---|---|
Density | 1.47±0.1 g/cm3(Predicted) |
pka | 3.61±0.21(Predicted) |
InChIKey | NSPHQWLKCGGCQR-DLJDZFDSSA-N |
FDA UNII | 7IK8Z952OK |
ATC code | A06AX07 |
Plecanatide Chemical Properties,Uses,Production
Uses
Plecanatide is used in the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation. It works as a laxative by drawing water in to the gastrointestinal tract thereby softening stool and encouraging its natural passage.
Enzyme inhibitor
This uroguanylin analogue (FW = 1681.90 g/mol; CAS 467426-54-6), also known by the codename SP-304, binds to and activates guanylate cyclase-C (GC-C) receptors (EC50 ≈ 0.3 μM) expressed on the epithelial cells lining turn sequentially activates protein kinase G-II and the chloride channel known as the Cystic Fibrosis Transmembrane-conductance Regulator (CFTR) to regulate ion and fluid transport, to promote epithelial cell homeostasis, and to maintain barrier function in the GI mucosa. Plecanatide is a hexadecapeptide that is structurally identical to uroguanylin, except for an glutamate substitution at position-3. Oral treatment with plecanatide at a dose range between 0.05-2.5 mg/kg per day is as effective as once-daily treatment with 5-amino salicylic acid (100 mg/kg) or sulfasalazine (80 mg/kg). Amelioration of colitis by the treatment with plecanatide or dolcanatide was not dose-dependent, most likely due to saturation of available GC-C receptors.
Plecanatide Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
AFINE CHEMICALS LIMITED | +86-0571-85134551 | info@afinechem.com | China | 15396 | 58 |
Apextide Co Ltd | +undefined15700198315 | senjie.hou@sinopep.com | China | 71 | 58 |
Shanghai Chinqesen Biotechnology Co., Ltd. | +86-16628886292 +86-19521323435 | sales2@qschem-pharma.com | China | 42 | 58 |
Shanghai Yunao International Trade Co., Ltd | +8617621705551 | asdf@shanghaihg.cn | China | 265 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
Shanghai Getian Industrial Co., LTD | +86-15373193816 +86-15373193816 | mike@ge-tian.com | China | 274 | 58 |
Alpha Biopharmaceuticals Co., Ltd | +86-411-39042497 +8613921981412 | sales@alphabiopharm.com | China | 888 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
View Lastest Price from Plecanatide manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-05-15 | Plecanatide
467426-54-6
|
US $28.00 / box | 1box | 99% | 20000 | Shanghai Getian Industrial Co., LTD | ||
2024-05-10 | Plecanatide
467426-54-6
|
US $75.00-750.00 / kg | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd | ||
2024-03-31 | Plecanatide
467426-54-6
|
US $30.00-20.00 / kg | 1kg | 99% | 2000000 | Shanghai Chinqesen Biotechnology Co., Ltd. |
- Plecanatide
467426-54-6
- US $28.00 / box
- 99%
- Shanghai Getian Industrial Co., LTD
- Plecanatide
467426-54-6
- US $75.00-750.00 / kg
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
- Plecanatide
467426-54-6
- US $30.00-20.00 / kg
- 99%
- Shanghai Chinqesen Biotechnology Co., Ltd.