6(5H)-Phenanthridone
- CAS No.
- 1015-89-0
- Chemical Name:
- 6(5H)-Phenanthridone
- Synonyms
- PJ 97A;NSC 11021;NSC 40943;NSC 61083;WD 99-004344;Phenantridone;PHENANTHRIDONE;PHENANTHRIDINONE;6-Phenanthridone;6-Phenanthridinol
- CBNumber:
- CB3386736
- Molecular Formula:
- C13H9NO
- Molecular Weight:
- 195.22
- MDL Number:
- MFCD00004988
- MOL File:
- 1015-89-0.mol
- MSDS File:
- SDS
| Melting point | 290-292 °C(lit.) |
|---|---|
| Boiling point | 435 °C |
| Density | 1.230±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMF: 1mg/mL; DMF:PBS (pH 7.2) (1:5): 0.16mg/mL |
| form | powder to crystal |
| pka | 13.27±0.20(Predicted) |
| color | White to Light yellow to Light orange |
| Water Solubility | Soluble in DMSO (5 mg/ml). Insoluble in water. |
| λmax | 338nm(EtOH)(lit.) |
| BRN | 140641 |
| CAS DataBase Reference | 1015-89-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | AVQ13AUB5J |
| NIST Chemistry Reference | 6(5H)-phenanthridinone(1015-89-0) |
| EPA Substance Registry System | 6-Phenanthridinone (1015-89-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | SG0370000 | |||||||||
| HS Code | 29337900 | |||||||||
| NFPA 704 |
|
6(5H)-Phenanthridone price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 299634 | 6-(5H)-Phenanthridinone technical grade | 1015-89-0 | 1g | $25.72 | 2024-03-01 | Buy |
| TCI Chemical | P1998 | 6(5H)-Phenanthridinone >98.0%(HPLC)(N) | 1015-89-0 | 1g | $34 | 2024-03-01 | Buy |
| TCI Chemical | P1998 | 6(5H)-Phenanthridinone >98.0%(HPLC)(N) | 1015-89-0 | 5g | $115 | 2024-03-01 | Buy |
| Alfa Aesar | B25187 | 6(5H)-Phenanthridinone, 96% | 1015-89-0 | 1g | $37.65 | 2024-03-01 | Buy |
| Alfa Aesar | B25187 | 6(5H)-Phenanthridinone, 96% | 1015-89-0 | 5g | $126.65 | 2024-03-01 | Buy |
6(5H)-Phenanthridone Chemical Properties,Uses,Production
Uses
6(5H)-Phenanthridinone is used as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis. It acts as a reactant in the synthesis of 5,6-dihydrophenanthridine sulfonamides, oxidative coupling with diphenylacetylene, direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. It is used as HIV-1 integrase inhibitor.
Uses
6-Phenanthridone is a poly(ADP-ribose) polymerase (PARP) inhibitor with immunosuppressive effects. 6-Phenanthridone has been shown to inhibit concanavalin A-induced lymphocyte proliferation.
Definition
ChEBI: A member of the class of phenanthridines that is phenanthridine with an oxo substituent at position 6. A poly(ADP-ribose) polymerase (PARP) inhibitor, it has been shown to exhibit immunosuppressive activity.
Synthesis Reference(s)
Canadian Journal of Chemistry, 35, p. 180, 1957 DOI: 10.1139/v57-027
Journal of the American Chemical Society, 79, p. 1245, 1957 DOI: 10.1021/ja01562a054
General Description
6-(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose)polymerase (PARP)-1 activity. The ability of 6-(5H)-phenanthridinone to potentiate the effect of ionizing radiation on tumour cells was evaluated. Action of 6-(5H)-phenanthridinone, one of the most potent PARP inhibitor, on RDM4 murine lymphoma cells in culture was evaluated.
6(5H)-Phenanthridone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12834 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 7629 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5889 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18150 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20284 | 58 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29880 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17365 | 58 |
View Lastest Price from 6(5H)-Phenanthridone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-04 | 6(5H)-Phenanthridone
1015-89-0
|
US $30.00-10.00 / KG | 50KG | 99% | 500000kg | Hebei Weibang Biotechnology Co., Ltd | |
 |
2024-11-01 | 6(5H)-Phenanthridone
1015-89-0
|
US $44.00-593.00 / g | 25g | 0.98 | 25kg | Shanghai UCHEM Inc. | |
 |
2024-10-11 | 6(5H)-Phenanthridone
1015-89-0
|
US $10.70 / kg | 10kg | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
-
- 6(5H)-Phenanthridone
1015-89-0
- US $30.00-10.00 / KG
- 99%
- Hebei Weibang Biotechnology Co., Ltd
-
- 6(5H)-Phenanthridone
1015-89-0
- US $44.00-593.00 / g
- 0.98
- Shanghai UCHEM Inc.
-
- 6(5H)-Phenanthridone
1015-89-0
- US $10.70 / kg
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
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