L-NORPSEUDOEPHEDRINE
- CAS No.
- 37577-07-4
- Chemical Name:
- L-NORPSEUDOEPHEDRINE
- Synonyms
- L-NORPSEUDOEPHEDRINE;l-Pseudonorephedrine;(-)-Pseudo Norephedrine;(R,R)-(-)-Norpseudoephedrine;(1R,2R)-(-)-Norpseudoephedrine;(1R,2R)-2-AMino-1-phenyl-1-propanol;(1R,2R)-2-Amino-1-phenylpropane-1-ol;(R)-α-[(R)-1-Aminoethyl]benzenemethanol;(-)-threo-2-AMino-2-Methyl-1-phenylethanol;[R-(R*,R*)]-α-(1-aMinoethyl)benzeneMethanol
- CBNumber:
- CB3491920
- Molecular Formula:
- C9H13NO
- Molecular Weight:
- 151.21
- MDL Number:
- MFCD01711267
- MOL File:
- 37577-07-4.mol
| Melting point | 77-78 °C |
|---|---|
| Boiling point | 288.1±20.0 °C(Predicted) |
| Density | 1.071±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 12.07±0.45(Predicted) |
| FDA UNII | QQ0FVC4PXS |
| EPA Substance Registry System | Benzenemethanol, .alpha.-[(1R)-1-aminoethyl]-, (.alpha.R)- (37577-07-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H318 |
| Precautionary statements | P280-P301+P310-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36 |
| Safety Statements | 26 |
| RIDADR | UN 2811 6.1/PG 3 |
L-NORPSEUDOEPHEDRINE Chemical Properties,Uses,Production
Uses
An enatiomer of (+)-Pseudonorephedrine (P839585). (-)-Pseudonorephedrine is metabolite of Cathinone (C225700) and possesses amphetamine-like stimulus properties. Studies show that (-)-Pseudonorephedri ne enhances the analgesic and rate decreasing effects of Morphine (M652290) but inhibits discriminative properties.
Definition
ChEBI: Phenylpropanolamine is an amphetamine in which the parent 1-phenylpropan-2-amine skeleton is substituted at position 1 with an hydroxy group. A decongestant and appetite suppressant, it is commonly used in prescription and over-the-counter cough and cold preparations. It has a role as a sympathomimetic agent and a nasal decongestant.
Purification Methods
Purify (-)-nor--ephedrine by recrystallisation from H2O, MeOH, EtOH, Et2O/pet ether or *C6H6 (plates). The mandelate salt has m 163.5o (from EtOH/Et2O) and [] D -41.3o (c 0.8, H2O) [Jarowski & Hartung J Org Chem 8 564 566 567 1943]. The hydrochloride is purified by dissolving 1.44g in 96% EtOH (5mL), adding Et2O (16mL) and cooling; it has m 178-179o (m180-181o is also reported) and [] 30D -42.9o (c 1.8, H2O) [Fles & Markovac-Prpic Croat Chem Acta 29 186 1957]. [Beilstein 13 I 252, 13 II 370, 13 III 1716, 13 IV 1874.]