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BMS-908662

BMS-908662 Structure
BMS-908662 structure
CAS No.
870603-16-0
Chemical Name:
BMS-908662
Synonyms
BMS-908662;BMS-908662(1X-281);Carbamic acid, N-[6-[2-(5-chloro-2-methylphenyl)-2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl]-1H-benzimidazol-2-yl]-, methyl ester
CBNumber:
CB34919927
Molecular Formula:
C24H19ClN4O4
Molecular Weight:
462.89
MDL Number:
MOL File:
870603-16-0.mol
Last updated:2025-04-18 09:52:10
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BMS-908662 Properties

Density 1.526±0.06 g/cm3(Predicted)
pka 10.77±0.20(Predicted)
FDA UNII DW2NWI3TFN

BMS-908662 Chemical Properties,Uses,Production

Uses

XL-281 (BMS-908662) is an orally active inhibitor for RAF kinase, with IC50s of 2.6, 4.5 and 6 nM, for CRAF, B-RAF, and B-RAFV600E, respectively. XL-281 exhibits antitumor activity[1].

IC 50

c-Raf: 2.6 nM (IC50); B-Raf: 4.5 nM (IC50); B-RafV600E: 6 nM (IC50)

References

[1] Dickson MA, et al., Phase I study of XL281 (BMS-908662), a potent oral RAF kinase inhibitor, in patients with advanced solid tumors. Invest New Drugs. 2015 Apr;33(2):349-56. DOI:10.1007/s10637-014-0191-5

BMS-908662 Preparation Products And Raw materials

Raw materials

Preparation Products

BMS-908662 Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 12952 65
Chengdu Novel Biomedical Co., Ltd. 028-85255396 18302801538 cdnovell@163.com China 2353 58
Chunchuang (Wuhan) Technology Co., Ltd 15727060112 yutianchun2007@126.com China 10000 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24641 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5236 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
Zhengzhou Haode Pharmaceutical Technology Co.,Ltd 18037386321 3330511471@qq.com China 284 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
BOC Sciences 65
Chengdu Novel Biomedical Co., Ltd. 58
Chunchuang (Wuhan) Technology Co., Ltd 58
TargetMol Chemicals Inc. 58
Nantong QuanYi Biotechnology Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Zhengzhou Haode Pharmaceutical Technology Co.,Ltd 58

View Lastest Price from BMS-908662 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Xl-281 pictures 2024-11-11 Xl-281
870603-16-0
 US $293.00-987.00 / mg 98.60% 10g TargetMol Chemicals Inc.
  • Xl-281 pictures
  • Xl-281
    870603-16-0
  • US $293.00-987.00 / mg
  • 98.60%
  • TargetMol Chemicals Inc.

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BMS-908662 Carbamic acid, N-[6-[2-(5-chloro-2-methylphenyl)-2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl]-1H-benzimidazol-2-yl]-, methyl ester BMS-908662(1X-281) 870603-16-0