4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE
- CAS No.
- 4233-33-4
- Chemical Name:
- 4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE
- Synonyms
- PTAD;4-PHENYL-3;AURORA KA-3851;Mosapride Impurity 24;4-Phenyl-1,2,4-triazole-3,5-dione;4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE;4-phenyl-1,2,4-triazole-3,5-quinone;4-Phenyl-1,2,3-triazoline-3,5-dione;4-Phenyl-4H-1,2,4-triazole-3,5-dione;4-PHENYL-3H-1,2,4-TRIAZOLINE-3,5-DIONE
- CBNumber:
- CB3769656
- Molecular Formula:
- C8H5N3O2
- Molecular Weight:
- 175.14
- MDL Number:
- MFCD00003148
- MOL File:
- 4233-33-4.mol
- MSDS File:
- SDS
Melting point | 165-170 °C (dec.)(lit.) |
---|---|
Boiling point | 263.8±23.0 °C(Predicted) |
Density | 1.47±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | Chloroform (Sparingly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
form | Solid |
pka | -1.71±0.20(Predicted) |
color | Red to Dark Red |
BRN | 141548 |
InChIKey | ISULLEUFOQSBGY-UHFFFAOYSA-N |
CAS DataBase Reference | 4233-33-4(CAS DataBase Reference) |
FDA UNII | V3X3G4TFG6 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P280-P305+P351+P338 |
Safety Statements | 22-24/25 |
WGK Germany | 3 |
HS Code | 29339900 |
4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE price More Price(31)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 280992 | 4-Phenyl-1,2,4-triazoline-3,5-dione 97% | 4233-33-4 | 1g | $107 | 2024-03-01 | Buy |
Sigma-Aldrich | 280992 | 4-Phenyl-1,2,4-triazoline-3,5-dione 97% | 4233-33-4 | 5g | $326 | 2024-03-01 | Buy |
TCI Chemical | P1184 | 4-Phenyl-1,2,4-triazoline-3,5-dione | 4233-33-4 | 1g | $108 | 2024-03-01 | Buy |
TCI Chemical | P1184 | 4-Phenyl-1,2,4-triazoline-3,5-dione | 4233-33-4 | 5g | $367 | 2024-03-01 | Buy |
TCI Chemical | P1184 | 4-Phenyl-1,2,4-triazoline-3,5-dione | 4233-33-4 | 25g | $964 | 2024-03-01 | Buy |
4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE Chemical Properties,Uses,Production
Chemical Properties
4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE is Red Solid
Uses
4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE is used in the methods for determining levels of 1,25 dihydroxyvitamin d2 and d3 in biological and food samples and dietary supplements.
Uses
4-Phenyl-1,2,4-triazoline-3,5-dione (PTAD) can be used as an efficient and selective reagent for the oxidation of thiols to disulfides.
It can also be used:???????
- As a dehydrogenating agent to synthesize annulated dihydropyridazines by inverse [4+2] cycloaddition reaction between cyclic alkenes and 1,2,4,5-tetrazines.???????
- As a dienophile to synthesize cycloaddition products by fast hetero-Diels?Alder reactions.???????
- As an efficient oxidizing agent for the synthesis of pyridine derivatives from 1,4-dihydropyridines.
- In the synthesis of urazoles via [3+2] cycloaddition with allylsilanes.
Uses
4-Phenyl-1,2,4-triazoline-3,5-dione may be used as a derivatizing reagent for the determination of trace levels of 25-hydroxyvitamin D and its C-3 epimer in biological samples and cholecalciferol (vitamin D3) in fortified infant formula, milk and milk powder using liquid chromatography–tandem mass spectrometry (LC–MS/MS)technique.
Synthesis Reference(s)
Synthetic Communications, 17, p. 409, 1987 DOI: 10.1080/00397918708063918
General Description
4-Phenyl-1,2,4-triazoline-3,5-dione, also known as Cookson reagent, is a strong dienophile, which gives a stable Diels-Alder adduct quantitatively within a short time and under mild conditions. It is commonly used as a protecting group of the diene moiety for the synthesis of vitamin D3 (VD3)-related compounds.
Purification Methods
PTAD forms carmine red needles by sublimation (ice cold finger) at 100o/0.1mm, and/or by recrystallisation from EtOH. IR: 1760 and 1780 cm-1 . [Cookson et al. Org Synth 51 121 1971, Moore max et al. J Org Chem 39 3700 1974, Beilstein 26 I 57, 26 III/IV 540.]
4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shaanxi Dideu Medichem Co. Ltd | 18192627656 | 1012@dideu.com | China | 2995 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16914 | 58 |
Chembon Pharmaceutical Co., Ltd. | +86-28-8425-2981 | CHINA | 724 | 55 | |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2136 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | 1015@dideu.com | China | 4088 | 58 |
View Lastest Price from 4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-08-22 | Mosapride Impurity 24 | US $0.00-0.00 / mg | 10mg | 0.98 | 10g | ShenZhen H&D Pharmaceutical Technology Co., LTD | ||
2024-08-15 | 4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE
4233-33-4
|
US $20.00-100.00 / KG | 1KG | 99% | 200000KG | Shaanxi Dideu Medichem Co. Ltd | ||
2019-07-06 | 4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE
4233-33-4
|
US $2.00 / KG | 1KG | 99% | Customise | Career Henan Chemical Co |
- Mosapride Impurity 24
- US $0.00-0.00 / mg
- 0.98
- ShenZhen H&D Pharmaceutical Technology Co., LTD
- 4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE
4233-33-4
- US $20.00-100.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
- 4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE
4233-33-4
- US $2.00 / KG
- 99%
- Career Henan Chemical Co