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ChemicalBook >> CAS DataBase List >>2,6-Piperidinedione, 3-[4-(3-thienyl)-1H-1,2,3-triazol-1-yl]-

2,6-Piperidinedione, 3-[4-(3-thienyl)-1H-1,2,3-triazol-1-yl]-

2,6-Piperidinedione, 3-[4-(3-thienyl)-1H-1,2,3-triazol-1-yl]- Structure
2,6-Piperidinedione, 3-[4-(3-thienyl)-1H-1,2,3-triazol-1-yl]- structure
CAS No.
2367619-63-2
Chemical Name:
2,6-Piperidinedione, 3-[4-(3-thienyl)-1H-1,2,3-triazol-1-yl]-
Synonyms
TMX-4100;2,6-Piperidinedione, 3-[4-(3-thienyl)-1H-1,2,3-triazol-1-yl]-;3-[4-(thiophen-3-yl)-1H-1,2,3-triazol-1-yl]piperidine-2,6-dione
CBNumber:
CB410315059
Molecular Formula:
C11H10N4O2S
Molecular Weight:
262.29
MDL Number:
MOL File:
2367619-63-2.mol
Last updated:2024-10-28 23:16:16
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2,6-Piperidinedione, 3-[4-(3-thienyl)-1H-1,2,3-triazol-1-yl]- Properties

Density 1.65±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
pka 10.45±0.40(Predicted)
form Solid
color White to off-white

2,6-Piperidinedione, 3-[4-(3-thienyl)-1H-1,2,3-triazol-1-yl]- Chemical Properties,Uses,Production

Biological Activity

TMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. TMX-4100 shows a high degradation preference for PDE6D with the DC50 values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4100 can be used for the research of multiple myeloma[1]. TMX-4100 (compound 3; 1 μM; 4 h) shows a high degradation preference for PDE6D in MOLT4 cells[1].TMX-4100 has better proteome-wide degradation selectivity in MOLT4 cells, compare to PDE6D degrader FPFT-2216[1].TMX-4100 does not impede the growth of KRAS-dependent cell lines (MIA PaCa-2, NCI-H358, AGS, PA-TU-8988T cells)[1].

References

[1]. Teng M, et al. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 Jan 13;65(1):747-756.

2,6-Piperidinedione, 3-[4-(3-thienyl)-1H-1,2,3-triazol-1-yl]- Preparation Products And Raw materials

Raw materials

Preparation Products

2,6-Piperidinedione, 3-[4-(3-thienyl)-1H-1,2,3-triazol-1-yl]- Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		support@targetmol.com United States 38631 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1466 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 15317229551 15151849396@163.com China 996 58
Changzhou Bojia Biomedical Technology Co., Ltd. 2122619822 czbjpharma@126.com China 18478 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24644 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11974 58
https://hanhongsci.com/ 021-54306202 18917919676 info@hanhongsci.com China 29979 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9266 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Jilin Province Woda Biotechnology Co., Ltd. 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 58
Changzhou Bojia Biomedical Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
https://hanhongsci.com/ 58
RD International Technology Co., Limited 58

View Lastest Price from 2,6-Piperidinedione, 3-[4-(3-thienyl)-1H-1,2,3-triazol-1-yl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
TMX-4100 pictures 2024-10-28 TMX-4100
2367619-63-2
 US $297.00 / mg 10g TargetMol Chemicals Inc.
  • TMX-4100 pictures
  • TMX-4100
    2367619-63-2
  • US $297.00 / mg
  • TargetMol Chemicals Inc.
2,6-Piperidinedione, 3-[4-(3-thienyl)-1H-1,2,3-triazol-1-yl]- TMX-4100 3-[4-(thiophen-3-yl)-1H-1,2,3-triazol-1-yl]piperidine-2,6-dione 2367619-63-2