Fendosal
- CAS No.
- 53597-27-6
- Chemical Name:
- Fendosal
- Synonyms
- hp129;CS-86;alnovin;FENDOSAL;Fendozal;P 71-0129;5-(4,5-dihydro-2-phenyl-3h-benz[e]indol-3-yl)salicylic acid;2-hydroxy-5-{2-phenyl-3H,4H,5H-benzo[e]indol-3-yl}benzoic acid;3-(3-carboxy-4-hydroxyphenyl)-4,5-dihydro-2-phenylbenz[e]indole;5-(4,5-dihydro-2-phenyl-3h-benz(e)indol-3-yl)-2-hydroxybenzoicacid
- CBNumber:
- CB4107778
- Molecular Formula:
- C25H19NO3
- Molecular Weight:
- 381.42
- MDL Number:
- MFCD00866078
- MOL File:
- 53597-27-6.mol
- MSDS File:
- SDS
| Melting point | 223-225° (dec) |
|---|---|
| Boiling point | 508.82°C (rough estimate) |
| Density | 1.2182 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| pka | 2.40±0.10(Predicted) |
| CAS DataBase Reference | 53597-27-6(CAS DataBase Reference) |
| FDA UNII | 9Z709558TZ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Toxicity | LD50 in mice, rats, rabbits (mg/kg): 740, 450, 560 orally; in mice (mg/kg): 510 i.p. (Lassman) |
Fendosal price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0010526 | 2-HYDROXY-5-(2-PHENYL-4,5-DIHYDRO-BENZO[E]INDOL-3-YL)-BENZOIC ACID 95.00% | 53597-27-6 | 5MG | $500.03 | 2021-12-16 | Buy |
| AK Scientific | P028 | Fendosal | 53597-27-6 | 250mg | $677 | 2021-12-16 | Buy |
| Matrix Scientific | 090375 | 5-(4,5-Dihydro-2-phenyl-3H-benz[e]indol-3-yl)-salicylic acid 95+% | 53597-27-6 | 250mg | $765 | 2021-12-16 | Buy |
| Matrix Scientific | 090375 | 5-(4,5-Dihydro-2-phenyl-3H-benz[e]indol-3-yl)-salicylic acid 95+% | 53597-27-6 | 1g | $1425 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0010526 | 2-HYDROXY-5-(2-PHENYL-4,5-DIHYDRO-BENZO[E]INDOL-3-YL)-BENZOIC ACID 95.00% | 53597-27-6 | 1G | $1575 | 2021-12-16 | Buy |
Fendosal Chemical Properties,Uses,Production
Originator
Alnovin,Hoechst
Uses
Anti-inflammatory.
Definition
ChEBI: Fendosal is a benzoindole that is 4,5-dihydro-3H-benzo[e]indole in which the nitrogen is substituted by a 3-carboxy-4-hydroxyphenyl group. A non-narcotic analgesic and non-steroidal anti-inflammatory drug, it has greater analgesic and inflammatory responses than aspirin but with less gastrointestinal toxicity. It has a role as a non-steroidal anti-inflammatory drug and a non-narcotic analgesic. It is a member of pyrroles, a benzoindole and a monohydroxybenzoic acid.
Manufacturing Process
To a stirred refluxing solution of 20.2 g (0.1 mole) of 1-(1-pyrrolidino)-3,4-
dihydronaphthalene and 50 ml of toluene was added dropwise during 30 minutes under nitrogen a solution of 20.1 g (0.1 mole) of phenacyl bromide in
65 ml of dry toluene. The mixture was heated under reflux for 6 hours, diluted
with 50 ml of water, refluxed for 4 hours, and cooled. The layers were
separated and the aqueous phase was extracted with benzene. The organic
solution was dried over sodium sulfate and concentrated to a semi-solid.
Trituration with cold 30°-60° petroleum ether gave 23.6 g (78%) of solid, 2-
phenacyl-1-tetralone, MP: 73°-76°C. Recrystallization from 60°-90° petroleum
ether raised the melting point to 87°-88°C.
A mixture of 20.0 g (0.076 mole) of 2-phenacyl-1-tetralone, 11.6 g (0.076
mole) of 5-aminosalicyclic acid, and 70 ml of glacial acetic acid was heated
under reflux for 4 hours, cooled, diluted with 10 ml of water and filtered. The
filter cake was washed with water and dried to provide 15.5 g of solid, 5-(4,5-
dihydro-2-phenyl-3H-benz[e]indol-3-yl)-2-hydroxy-benzoic acid. MP: 215°-
218°C. Recristallization from benzene-cyclohexane gave 6.5 g (22%) of yellow
crystals, MP: 245°-247°C.
brand name
Alnovin(Hoechst-Roussel).
Therapeutic Function
Analgesic, Antiinflammatory, Antipyretic
Fendosal Preparation Products And Raw materials
Fendosal Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49979 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32343 | 55 |
| Chembest Research Laboratories Limited | +86-21-20908456 | sales@BioChemBest.com | China | 6005 | 61 |
| China Langchem Inc. | 0086-21-58956006 | China | 7811 | 57 | |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 021-51613915-820 13611835272 | mmwang@sunwaypharm.cn | China | 9734 | 57 |
