AMANTANIUM BROMIDE
- CAS No.
- 58158-77-3
- Chemical Name:
- AMANTANIUM BROMIDE
- Synonyms
- Amantanil bromidum;AMANTANIUM BROMIDE;inhibit,Amantanium bromide,Amantanium,Inhibitor
- CBNumber:
- CB41093142
- Molecular Formula:
- C25H46BrNO2
- Molecular Weight:
- 472.54224
- MDL Number:
- MFCD01668404
- MOL File:
- 58158-77-3.mol
- MSDS File:
- SDS
Melting point | 182-184° |
---|---|
storage temp. | Store at -20°C |
solubility | Soluble in DMSO |
FDA UNII | K0435HZQ57 |
AMANTANIUM BROMIDE Chemical Properties,Uses,Production
Description
Amantanium bromide is a quaternary ammonium antibacterial/antifugal agent useful as a surgical antiseptic and for the topical therapy of mucous and cutaneous infections. It appears somewhat more effective than cetylpyridinium chloride and benzalkonium chloride.
Originator
Rotta Research (Italy)
Manufacturing Process
A solution of 21.7 g (0.11 mole) 1-adamantanecarboxylic acid chloride in 100
ml ether was added to a solution of 19.4 g (0.22 mole) 2-
dimethylaminoethanol in 200 ml ether. The reaction mixture was stirred
overnight at room temperature. Then additional 15.0 g (0.17 mole) 2-
dimethylaminoethanol was added and the reaction mixture again stirred
overnight. The reaction mixture was poured into 300 ml water and treated
with 20 ml of 10% NaOH solution. From the ether layer was recovered 23.0 g
of 2-dimethylaminoethyl 1-adamantanecarboxylate as oil.
The 2-dimethylaminoethyl 1-adamantanecarboxylate was mixed with 1-
bromodecan and allowed to stand for about 6 weeks. The resultant crystalline
mass was washed with ether and dried to gave 2-(1’-
adamantanecarbonyloxy)ethyldimethyldecylammonium bromide as white
crystals, melting point 183°-184.5°C (two recrystallizations from ethyl
acetate).
brand name
AMANTOL
Therapeutic Function
Antiseptic
AMANTANIUM BROMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
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ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
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TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34571 | 58 |
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Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52861 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 27322 | 60 |
Beijing Hechemist Technology CO.,LTD | 18511709189 | sales@hechemist.com | China | 3436 | 58 |