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ChemicalBook >> CAS DataBase List >>Urea, N-[4-[[(2S)-2-(4-morpholinylmethyl)-1-pyrrolidinyl]sulfonyl]phenyl]-N'-[4-(trifluoromethyl)phenyl]-

Urea, N-[4-[[(2S)-2-(4-morpholinylmethyl)-1-pyrrolidinyl]sulfonyl]phenyl]-N'-[4-(trifluoromethyl)phenyl]-

Urea, N-[4-[[(2S)-2-(4-morpholinylmethyl)-1-pyrrolidinyl]sulfonyl]phenyl]-N'-[4-(trifluoromethyl)phenyl]- Structure
Urea, N-[4-[[(2S)-2-(4-morpholinylmethyl)-1-pyrrolidinyl]sulfonyl]phenyl]-N'-[4-(trifluoromethyl)phenyl]- structure
CAS No.
2230496-99-6
Chemical Name:
Urea, N-[4-[[(2S)-2-(4-morpholinylmethyl)-1-pyrrolidinyl]sulfonyl]phenyl]-N'-[4-(trifluoromethyl)phenyl]-
Synonyms
ZL0590;Urea, N-[4-[[(2S)-2-(4-morpholinylmethyl)-1-pyrrolidinyl]sulfonyl]phenyl]-N'-[4-(trifluoromethyl)phenyl]-;non-KAc binding site,ZL0590,ZL-0590,BRD4 BD1,Inhibitor,acute airway inflammation,inhibit,Epigenetic Reader Domain,ZL 0590
CBNumber:
CB411035316
Molecular Formula:
C23H27F3N4O4S
Molecular Weight:
512.55
MDL Number:
MOL File:
2230496-99-6.mol
Last updated:2024-07-02 08:55:07
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Urea, N-[4-[[(2S)-2-(4-morpholinylmethyl)-1-pyrrolidinyl]sulfonyl]phenyl]-N'-[4-(trifluoromethyl)phenyl]- Properties

Density 1.411±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
form Solid
pka 13.38±0.70(Predicted)
color White to off-white

Urea, N-[4-[[(2S)-2-(4-morpholinylmethyl)-1-pyrrolidinyl]sulfonyl]phenyl]-N'-[4-(trifluoromethyl)phenyl]- Chemical Properties,Uses,Production

Biological Activity

ZL0590 is a potent, orally active BRD4 BD1-selective inhibitor with an IC50 of 90 nM for human BRD4 BD1. ZL0590 exhibits significant anti-inflammatory activities[1].

References

[1]. Liu Z, et al. Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site. J Med Chem. 2022;65(3):2388-2408.

Urea, N-[4-[[(2S)-2-(4-morpholinylmethyl)-1-pyrrolidinyl]sulfonyl]phenyl]-N'-[4-(trifluoromethyl)phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Urea, N-[4-[[(2S)-2-(4-morpholinylmethyl)-1-pyrrolidinyl]sulfonyl]phenyl]-N'-[4-(trifluoromethyl)phenyl]- Suppliers

Global( 4)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou ChangCun Biotechnology Co., Ltd. 0571-; 13567100326 158848739@qq.com China 108 50
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 23963 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9274 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 cindy.huang@synzest.com China 12007 58
Supplier Advantage
Hangzhou ChangCun Biotechnology Co., Ltd. 50
TargetMol Chemicals Inc. 58
RD International Technology Co., Limited 58
Nanjing Shizhou Biology Technology Co.,Ltd 58
Urea, N-[4-[[(2S)-2-(4-morpholinylmethyl)-1-pyrrolidinyl]sulfonyl]phenyl]-N'-[4-(trifluoromethyl)phenyl]- ZL0590 non-KAc binding site,ZL0590,ZL-0590,BRD4 BD1,Inhibitor,acute airway inflammation,inhibit,Epigenetic Reader Domain,ZL 0590 2230496-99-6 C23H27F3N4O4S