CHYMOSTATIN
- CAS No.
- 9076-44-2
- Chemical Name:
- CHYMOSTATIN
- Synonyms
- AIDS-028443;CHYMOSTATIN;CHYMOSTATIN USP/EP/BP;ChyMostatin research grade;ACRYLAMIDE PROTEOMICS GRADE;Chymostatin from Microbial Source;chymostatin, mixture of components A;N-[-N-ALPHA-CARBONYL-CPD-X-PHE-AL]-PHE;Chymostatin - CAS 9076-44-2 - Calbiochem;CHYMOSTATIN, MIXTURE OF COMPONENTS A, B AND C
- CBNumber:
- CB4161466
- Molecular Formula:
- C92H121N21O18
- Molecular Weight:
- 1809.08
- MDL Number:
- MFCD00071059
- MOL File:
- 9076-44-2.mol
| Melting point | 205 °C |
|---|---|
| storage temp. | -20°C |
| solubility | DMSO: 10 mM Stock solutions stable for months at −20 °C. |
| form | White to slightly yellow solid or powder |
| color | White or off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| EWG's Food Scores | 1 |
| FDA UNII | W7MU4REM7L |
SAFETY
Risk and Safety Statements
| Hazard Codes | Xi |
|---|---|
| Risk Statements | 36/37/38 |
| Safety Statements | 22-24/25-36-26 |
| WGK Germany | 3 |
| RTECS | GC3047700 |
| F | 10-21 |
CHYMOSTATIN price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C7268 | Chymostatin microbial | 9076-44-2 | 1mg | $65.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | C7268 | Chymostatin microbial | 9076-44-2 | 5mg | $160 | 2024-03-01 | Buy |
| Sigma-Aldrich | 230790 | Chymostatin - CAS 9076-44-2 - Calbiochem Contains chymostatin "A" as a major form. | 9076-44-2 | 5mg | $144 | 2024-03-01 | Buy |
| Sigma-Aldrich | 230790 | Chymostatin - CAS 9076-44-2 - Calbiochem Contains chymostatin "A" as a major form. | 9076-44-2 | 25mg | $461 | 2024-03-01 | Buy |
| Sigma-Aldrich | 11004638001 | Chymostatin | 9076-44-2 | 10mg | $282 | 2024-03-01 | Buy |
CHYMOSTATIN Chemical Properties,Uses,Production
Description
Chymostatin is a bioactive peptide of microbial origin that acts as a protease inhibitor with selectivity for chymotryptase-
Uses
Chymostatin is a specific inhibitor of α-, β-, γ-, and δ-chymotrypsin.
Uses
Chymostatin has been used in a study that determined that molecular calculations are useful for evaluating the interactions between ligands, including inhibitors and homologous enzymes, in docking models. Chymostatin has also been used in a study to investigate the norovirus protease as an attractive target for antiviral drug development.
General Description
Chymostatin is a mixture of three components, A, B, and C. The component A being N-[((S)-1-carboxy-2-phenylethyl)-carbamoyl]-α-[2-iminohexahydro-4(S)-pyrimidyl]-L-glycyl-L-leucyl-phenylalaninal. The other two components B and C differ in that the L-leucyl residue is substituted by L-valine and L-isoleucine, respectively.
Biochem/physiol Actions
Chymostatin is a strong inhibitor of many proteases, including chymotrypsin, papain, chymotrypsin-like serine proteinases, chymases, and lysosomal cysteine proteinases such as cathepsins A,B,C, B, H, and L. It weakly inhibits human leucocyte elastase. It is effective at a final concentration of 100 to 200 μg/ml (10 to 100 μM). Chymostatin is often included in protease inhibitor cocktails used with plant extracts.
in vitro
chymostatin was found to be a potent inhibitor of human leucocyte chymotrypsin-like protease. its affinity to the leucocyte protease was found to be much higher than its affinity to bovine pancreatic alpha-chymotrypsin. chymsotatin also showed a weak inhibitory effect on the activity of human leucocyte elastase. in addition, the preincubation of chymostatin with 35so2-4-labeled cartilage before the addition of the human chymotrypsin-like protease to the tissue could also inhibit 35so2-4 release [1].
in vivo
the effect of chymostatin on c57bl/6j-dy dystrophic mice was studied. the locomotor activity of normal mice markedly increased, attaining a plateau at 8 weeks of age. serum levels of creatine phosphokinase were much higher in dystrophic mice when compared with normal mice, and dystrophic mice also showed a reduced muscle protein content. when 3-week-old dystrophic mice received chymostatin at 1 mg/kg, the decrease in locomotor activity could be retarded, serum enzyme levels significantly decreased, and muscle protein content also obviously increased. in addition, the survival time of chymostatin-treated dystrophic mice was prolonged [2].
References
1) Umezawa?et al.?(1970),?Chymostatin, a new chymotrypsin inhibitor produced by actinomycetes; J. Antibiot. (Tokyo)?23?425 2) Johnson?et al.?(1998),?Inactivation of chymotrypsin and human skin chymase: kinetics of time-dependent inhibition in the presence of substrate; Biochim. Biophys. Acta?953?269 3) Stein and Strimpler (1987),?Slow-binding of chymotrypsin and cathepsin G by the peptide aldehyde chymostatin; Biochemistry?26?2611 4) Roszkowska-Chojecka?et al.?(2015),?Effects of chymostatin, a chymase inhibitor, on blood pressure, plasma and tissue angiotensin II, renal haemodynamics and renal excretion in two models of hypertension in the rat; Exp. Physiol.?100?1093
CHYMOSTATIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alpha Biopharmaceuticals Co., Ltd | +86-15542445688 | sales@alabiochem.com | China | 888 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29811 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22883 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
View Lastest Price from CHYMOSTATIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-03-05 | CHYMOSTATIN
9076-44-2
|
US $1.00 / KG | 1KG | 98% HPLC | 10 tons | Career Henan Chemical Co |
-
- CHYMOSTATIN
9076-44-2
- US $1.00 / KG
- 98% HPLC
- Career Henan Chemical Co
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