2-Butyl-4-chloro-5-formylimidazole
- CAS No.
- 83857-96-9
- Chemical Name:
- 2-Butyl-4-chloro-5-formylimidazole
- Synonyms
- BCFI;2-BUTYL-4-CHLORO-1H-IMIDAZOLE-5-CARBALDEHYDE;2-BUTYL-5-CHLORO-1H-IMIDAZOLE-4-CARBALDEHYDE;2-Butyl-4-chloroimidazole-5-carboxaldehyde;Losaint-A;ALSTint-A03;Losartan potassium-1;LOSARTAN INTERMEDIATES;Losartan EP IMpurity D;Losartan impurity D CRS
- CBNumber:
- CB4185349
- Molecular Formula:
- C8H11ClN2O
- Molecular Weight:
- 186.64
- MDL Number:
- MFCD01934396
- MOL File:
- 83857-96-9.mol
- MSDS File:
- SDS
Melting point | 97-100 °C(lit.) |
---|---|
Boiling point | 384.1±22.0 °C(Predicted) |
Density | 1.240 |
vapor pressure | 0.001Pa at 25℃ |
storage temp. | Inert atmosphere,2-8°C |
solubility | soluble in methanol |
form | Powder to crystal |
pka | 8.87±0.10(Predicted) |
color | Pale Yellow to Brown |
Water Solubility | slightly soluble |
InChIKey | JLVIHQCWASNXCK-UHFFFAOYSA-N |
LogP | 2.5 at 25℃ and pH7.1 |
Surface tension | 58.3mN/m at 1.2g/L and 20℃ |
CAS DataBase Reference | 83857-96-9(CAS DataBase Reference) |
EWG's Food Scores | 1-2 |
FDA UNII | 7H170U0SWE |
EPA Substance Registry System | 2-Butyl-5-chloroimidazole-4-carbaldehyde (83857-96-9) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() GHS07,GHS09 |
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Signal word | Warning | |||||||||
Hazard statements | H317-H411 | |||||||||
Precautionary statements | P261-P272-P273-P280-P302+P352-P333+P313 | |||||||||
Hazard Codes | Xi,N | |||||||||
Risk Statements | 43-51/53 | |||||||||
Safety Statements | 24-37-61 | |||||||||
RIDADR | UN 3077 9/PG 3 | |||||||||
WGK Germany | 2 | |||||||||
HazardClass | IRRITANT | |||||||||
PackingGroup | III | |||||||||
HS Code | 29339900 | |||||||||
NFPA 704 |
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2-Butyl-4-chloro-5-formylimidazole price More Price(36)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 1370473 | Losartan Related Compound A United States Pharmacopeia (USP) Reference Standard | 83857-96-9 | 20mg | $1210 | 2024-03-01 | Buy |
Sigma-Aldrich | 559881 | 2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde 97% | 83857-96-9 | 25g | $169 | 2023-01-07 | Buy |
TCI Chemical | B2914 | 2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde >98.0%(GC) | 83857-96-9 | 25g | $36 | 2024-03-01 | Buy |
Sigma-Aldrich | Y0001072 | Losartan impurity D European Pharmacopoeia (EP) Reference Standard | 83857-96-9 | y0001072 | $153 | 2024-03-01 | Buy |
Sigma-Aldrich | T136964 | 2-BUTYL-4-CHLORO-1H-IMIDAZOLE-5-CARBALDEHYDE Aldrich | 83857-96-9 | 50mg | $179 | 2024-03-01 | Buy |
2-Butyl-4-chloro-5-formylimidazole Chemical Properties,Uses,Production
Description
2-Butyl-4-chloro-5-formylimidazole is an API intermediate used as an intermediate for the anti-hypertensive drug Chlosartan. It can be used in the chemical manufacture of many APIs and advanced intermediates. With the help of this chemical, a number of other chemicals can be manufactured that have further applications in industries such as Losartan manufacturing.
Chemical Properties
2-Butyl-4-chloro-5-formylimidazole is Yellow Solid
Uses
2-Butyl-4-chloro-5-formylimidazole is used for preparation of N-(biphenylylmethyl)imidazoles as angiotensin II antagonists
Uses
2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde may be used in the preparation of the following symmetrical esters of dialkyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate:
- dimethyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- diethyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- diisopropyl 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- diisobutyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- di-tert-butyl 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- bis(2-methoxyethyl) 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Application
2-Butyl-4-chloro-1H-imidazole-5-carboxaldehyde (Losartan EP Impurity D) is used for preparation of N-(biphenylylmethyl)imidazoles as angiotensin II antagonists. Losartan USP Related Compound A.
Synthesis Reference(s)
The Journal of Organic Chemistry, 64, p. 8084, 1999 DOI: 10.1021/jo9824910
Synthesis
2-Butyl-4-chloro-5-formylimidazole was synthesised as follows: Performing condensation reaction of pentamidine hydrochloride with glyoxal and controlling the pH value of the system in the range of 6.0-7.5; after the reaction terminates, arousing dehydration reaction of the compound of formula III, thereby obtaining 2-butyl-1H-imidazole-5(4H)-ketone; and finally, reacting 2-butyl-1H-imidazole-5(4H)-ketone with N,N-dimethylformamide in the presence of phosphorus oxychloride, thereby obtaining 2-butyl-4-chloro-5-formylimidazole.
storage
2-Butyl-4-chloro-5-formylimidazole is soluble in DMF, DMSO, Ethanol and Methanol.
2-Butyl-4-chloro-5-formylimidazole Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
JUYE XIANDAI fine chemistry Co.,Ltd | +86-18958038633; +8618958038633 | tony@sdhypharma.com | China | 64 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12450 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 | daisy@crovellbio.com | China | 5828 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16914 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9332 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 | sales@nbinno.com | CHINA | 925 | 58 |
View Lastest Price from 2-Butyl-4-chloro-5-formylimidazole manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-08-13 | 2-Butyl-4-chloro-5-formylimidazole
83857-96-9
|
US $1.90 / KG | 1KG | 99% | 10 ton | Hebei Guanlang Biotechnology Co,.LTD | |
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2023-08-30 | 2-Butyl-4-chloro-5-formylimidazole
83857-96-9
|
US $100.00 / KG | 1KG | 99% | 5000KG | Hebei Mojin Biotechnology Co., Ltd | |
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2023-06-26 | 2-Butyl-4-Chloro-5-Formylimidazole
83857-96-9
|
US $200.00 / kg | 1kg | 99% | 1000kg/Month | Hebei Mingeng Biotechnology Co., Ltd |
-
- 2-Butyl-4-chloro-5-formylimidazole
83857-96-9
- US $1.90 / KG
- 99%
- Hebei Guanlang Biotechnology Co,.LTD
-
- 2-Butyl-4-chloro-5-formylimidazole
83857-96-9
- US $100.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- 2-Butyl-4-Chloro-5-Formylimidazole
83857-96-9
- US $200.00 / kg
- 99%
- Hebei Mingeng Biotechnology Co., Ltd