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2-Butyl-4-chloro-5-formylimidazole

2-Butyl-4-chloro-5-formylimidazole structure

CAS No.: 83857-96-9

Chemical Name:: 2-Butyl-4-chloro-5-formylimidazole

Synonyms: BCFI;2-BUTYL-4-CHLORO-1H-IMIDAZOLE-5-CARBALDEHYDE;2-BUTYL-5-CHLORO-1H-IMIDAZOLE-4-CARBALDEHYDE;2-Butyl-4-chloroimidazole-5-carboxaldehyde;Losaint-A;ALSTint-A03;Losartan potassium-1;LOSARTAN INTERMEDIATES;Losartan EP IMpurity D;Losartan impurity D CRS

CBNumber:: CB4185349

Molecular Formula:: C8H11ClN2O

Molecular Weight:: 186.64

MDL Number:: MFCD01934396

MOL File:: 83857-96-9.mol

MSDS File:: SDS

Last updated:2025-02-26 21:25:56

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2-Butyl-4-chloro-5-formylimidazole Properties

Melting point	97-100 °C(lit.)
Boiling point	384.1±22.0 °C(Predicted)
Density	1.240
vapor pressure	0.001Pa at 25℃
storage temp.	Inert atmosphere,2-8°C
solubility	soluble in methanol
pka	8.87±0.10(Predicted)
form	Powder to crystal
color	Pale Yellow to Brown
Water Solubility	slightly soluble
InChIKey	JLVIHQCWASNXCK-UHFFFAOYSA-N
LogP	2.5 at 25℃ and pH7.1
Surface tension	58.3mN/m at 1.2g/L and 20℃
CAS DataBase Reference	83857-96-9(CAS DataBase Reference)
EWG's Food Scores	1-2
FDA UNII	7H170U0SWE
EPA Substance Registry System	2-Butyl-5-chloroimidazole-4-carbaldehyde (83857-96-9)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS09

Signal word

Warning

Hazard statements

H317-H411

Precautionary statements

P261-P272-P273-P280-P302+P352-P333+P313

Hazard Codes

Xi,N

Risk Statements

43-51/53

Safety Statements

24-37-61

RIDADR

UN 3077 9/PG 3

WGK Germany

HazardClass

IRRITANT

PackingGroup

III

HS Code

29339900

NFPA 704

	0
2		0

2-Butyl-4-chloro-5-formylimidazole price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	1370473	Losartan Related Compound A United States Pharmacopeia (USP) Reference Standard	83857-96-9	20mg	$1210	2024-03-01	Buy
Sigma-Aldrich	559881	2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde 97%	83857-96-9	25g	$169	2023-01-07	Buy
TCI Chemical	B2914	2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde >98.0%(GC)	83857-96-9	25g	$36	2024-03-01	Buy
Sigma-Aldrich	Y0001072	Losartan impurity D European Pharmacopoeia (EP) Reference Standard	83857-96-9	y0001072	$153	2024-03-01	Buy
Sigma-Aldrich	T136964	2-BUTYL-4-CHLORO-1H-IMIDAZOLE-5-CARBALDEHYDE Aldrich	83857-96-9	50mg	$179	2024-03-01	Buy

Product number	Packaging	Price	Buy
1370473	20mg	$1210	Buy
559881	25g	$169	Buy
B2914	25g	$36	Buy
Y0001072	y0001072	$153	Buy
T136964	50mg	$179	Buy

2-Butyl-4-chloro-5-formylimidazole Chemical Properties,Uses,Production

Description

2-Butyl-4-chloro-5-formylimidazole is an API intermediate used as an intermediate for the anti-hypertensive drug Chlosartan. It can be used in the chemical manufacture of many APIs and advanced intermediates. With the help of this chemical, a number of other chemicals can be manufactured that have further applications in industries such as Losartan manufacturing.

Chemical Properties

2-Butyl-4-chloro-5-formylimidazole is Yellow Solid

Uses

2-Butyl-4-chloro-5-formylimidazole is used for preparation of N-(biphenylylmethyl)imidazoles as angiotensin II antagonists

Uses

2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde may be used in the preparation of the following symmetrical esters of dialkyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate:

dimethyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
diethyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
diisopropyl 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
diisobutyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
di-tert-butyl 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
bis(2-methoxyethyl) 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Application

2-Butyl-4-chloro-1H-imidazole-5-carboxaldehyde (Losartan EP Impurity D) is used for preparation of N-(biphenylylmethyl)imidazoles as angiotensin II antagonists. Losartan USP Related Compound A.

Synthesis Reference(s)

The Journal of Organic Chemistry, 64, p. 8084, 1999 DOI: 10.1021/jo9824910

Synthesis

2-Butyl-4-chloro-5-formylimidazole was synthesised as follows: Performing condensation reaction of pentamidine hydrochloride with glyoxal and controlling the pH value of the system in the range of 6.0-7.5; after the reaction terminates, arousing dehydration reaction of the compound of formula III, thereby obtaining 2-butyl-1H-imidazole-5(4H)-ketone; and finally, reacting 2-butyl-1H-imidazole-5(4H)-ketone with N,N-dimethylformamide in the presence of phosphorus oxychloride, thereby obtaining 2-butyl-4-chloro-5-formylimidazole.

storage

2-Butyl-4-chloro-5-formylimidazole is soluble in DMF, DMSO, Ethanol and Methanol.

2-Butyl-4-chloro-5-formylimidazole synthesis

Synthesis of 2-Butyl-4-chloro-5-formylimidazole from (2-BUTYL-5-CHLORO-1H-IMIDAZOL-4-YL)METHANOL

2-Butyl-4-chloro-5-formylimidazole Preparation Products And Raw materials

Raw materials

Preparation Products

4’-[(2-butyl-4-chloro-5-hydroxymethyl)-1H-imidazol-1-yl)methyl]-[1,1’-Biphenyl]-2-carbonitrile (2-BUTYL-5-CHLORO-1H-IMIDAZOL-4-YL)METHANOL EPROSARTAN N-(4-Bromobenzyl)-2-butyl-4-chloro-1H-imidazole-5-carboxyaldehyde 2-Butyl-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde

2-Butyl-4-chloro-5-formylimidazole Suppliers

Global( 573)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
JUYE XIANDAI fine chemistry Co.,Ltd	+86-18958038633; +8618958038633	tony@sdhypharma.com	China	64	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531157085	abby@chuanghaibio.com	China	8808	58
Hebei Mujin Biotechnology Co.,Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12809	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5868	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29730	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-+86-371-66670886	info@dakenam.com	China	19805	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21628	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29858	58
NINGBO INNO PHARMCHEM CO., LTD.	13867897135	sales@nbinno.com	CHINA	923	58

Supplier	Advantage
JUYE XIANDAI fine chemistry Co.,Ltd	58
ANHUI WITOP BIOTECH CO., LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Mujin Biotechnology Co.,Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
NINGBO INNO PHARMCHEM CO., LTD.	58

View Lastest Price from 2-Butyl-4-chloro-5-formylimidazole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-23	2-Butyl-4-chloro-5-formylimidazole 83857-96-9	US $1.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-04-04	2-Butyl-4-chloro-5-formylimidazole 83857-96-9	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2025-03-21	2-Butyl-4-chloro-5-formylimidazole 83857-96-9	US $100.00 / KG	1KG	99%	5000KG	Hebei Mujin Biotechnology Co.,Ltd

2-Butyl-4-chloro-5-formylimidazole
83857-96-9
US $1.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

2-Butyl-4-chloro-5-formylimidazole
83857-96-9
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

2-Butyl-4-chloro-5-formylimidazole
83857-96-9
US $100.00 / KG
99%
Hebei Mujin Biotechnology Co.,Ltd

2-Butyl-4-chloro-5-formylimidazole Spectrum

2-Butyl-4-chloro-5-formylimidazole(83857-96-9)IR

83857-96-9(2-Butyl-4-chloro-5-formylimidazole)Related Search:

tert-Butyldimethylsilyl chloride tert-Butanol butyl rubber Tetrabutylammonium bromide 1-Vinylimidazole

Butyl acetate N-(n-Butyl)thiophosphoric triamide Methimazole n-Butyllithium Buprofezin

Cyhalofop-butyl 2-Butoxyethanol 1-Bromobutane Imidazole 1H-Imidazole-4-carbaldehyde

Butyl acrylate Zolasartan Difluorochloromethane

1of4

2-BUTYL-4-CHLORO-5-IMIDAZOLECARBOXALDEHYDE (BCFI) 2-Butyl-5-formyl-4-chloroimidazole 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde 2-Butyl-5-chloro-4-formylimidazole 97% 2-BUTYL-5-CHLORO-1H-IMIDAGOLE- 2-N-BUTYL-4(5)-CHLORO-1H-IMIDAZOLE-5(4)-CARBOXALDEHYDE (INTERMEDIATE OF LOSARTAN) 2-n-Butyl-4-chloro-5-formylimidazloe 2-butyl-4-chloro-5-imidazolecarboxyaldehyde 2-n-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde 2-Butyl-4(5)-chloro-1H-imidazole-5(4)-carbaldehyde 2-Butyl-5-chloro-1H-imidazole-4-carbaldehyde ,99% 2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde,2-Butyl-4-chloro-5-formylimidazole 2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde 97% 2-(But-1-yl)-5-chloro-1H-imidazole-4-carboxaldehyde 97% 2-(But-1-yl)-5-chloro-4-formyl-1H-imidazole Ethyl(2S)-2-[(3S,8aS)-3-Methyl-1,4-dioxo-octahydropyrrolo[1,2-alpha]pyrazin-2-yl]-4-phenylbutanoate 2-n-Butyl-4(5)-Chloro-1H-IMidazole-5(4)-Carboxaldehyde (BCFI) 2-Butyl-4-chloro-5-formylimidazole,99% LOSARTAN INTERMEDIATES 2-n-butyl-4(5)-Chloro-1H-imdazole-5(4)-carboxaldehyde 2-Butyl-5-chloro-4-formylimidazole 2-Butyl-5-choloro-1H-imidazole-4-carbaldehyde 2-Butyl-4-chloro-5-imidazolecarboxaldehyde 2-Butyl-5-Chloro-1H-Imidagole-4-Carbaldehyde 2-Buty1-4(5)-Chloro-5(4)Imidazolecarboxaldehyde 2N-Butyl-4(5)-Chloro-1H-Imidazole-5(4)-Oarboxaldehyde 2-BUTYL-5-CHLOROIMIDAZOLE-4-CARBOXALDEHYDE 2-BUTYL-4-CHLORO-IMIDAZOLE-5-CARBALDEHYDE 2-BUTYL-5-CHLORO-1H-IMIDAZOLE-4-CARBOXALDEHYDE 2-BUTYL-4-CHLORO-1H-IMIDAZOLE-5-CARBOXALDEHYDE 2-BUTYL-4-CHLORO-5-FORMYLIMIDAZLOE 2-BUTYL-4-CHLORO-5-FORMYLIMIDAZOLE 2-BUTYL-4(5)-CHLORO-5(4)IMIDAZOLECARBOXALDEHYDE 2-N-BUTYL-5-CHLORO-4-FORMYL IMIDAZOLE 2-N-BUTYL-4(5)-CHLORO-1H-IMIDAZOLE-5(4)-CARBOXALDEHYDE 2-N-BUTYL-4-CHLORO-5-FORMYLIMIDAZOLE 2-N-BUTYL-4-CHLOROIMIDAZOLE-5-CARBOXALDEHYDE 2-Butyl-5-chloro-1H-imidazole carboxaldehyde 2-Butyl-4(5)-chloro-5(4)-imidazolecarboxyaldehyde Losartan EP IMpurity D 2- butyl-4-chloro -5-forMyl iMidazoles (2-n-Butyl-5-chloro-imidazole-4-yl)-carboxaldehyde 2-Butyl-4-chloro-5-formylimidazole (BCFI) 2-N-Butyl-4-chloro-5-Formyl Imidazole (BCFI) Losartan potassium-1 2-(But-1-yl)-5-chloro-1H-imidazole-4-carboxaldehyde Losartan potassium impurity A ALSTint-A03 Losaint-A Losartan Impurity D (EP) Losartan Impurity 4(Losartan EP Impurity D) Losartan Potassium EP Impurity D Losartan impurity D CRS 2-Butyl-4-chloro-1H-imidazole-5-car 2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde > 1H-Imidazole-4-carboxaldehyde, 2-butyl-5-chloro- 2-Butyl-4-chloro-5-formylimidazole USP/EP/BP 2-Butyl-4-Chloro-5-Formyl-1H-Imidazole (BCFI)