Cryptotanshinone
- CAS No.
- 35825-57-1
- Chemical Name:
- Cryptotanshinone
- Synonyms
- CRYPTOTANSHINONE;Cryptotanshinon;Cryptotanshinone, Tanshinone c;CS-1284;98% BY HPLC;Tanshinone c;Cryptotanshine;Noncrystalline;yindanshentong;Crypttanshinone
- CBNumber:
- CB4222031
- Molecular Formula:
- C19H20O3
- Molecular Weight:
- 296.36
- MDL Number:
- MFCD07636810
- MOL File:
- 35825-57-1.mol
- MSDS File:
- SDS
| Melting point | 192°C(lit.) |
|---|---|
| Boiling point | 459.0±45.0 °C(Predicted) |
| Density | 1.23±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥5mg/mL |
| form | powder |
| color | orange-brown |
| optical activity | [α]/D -85.0±3.0°, c = 0.1 in chloroform |
| λmax | 263nm(lit.) |
| BRN | 5445400 |
| InChIKey | IJSBKZLSTIFYIE-FPKDZHNTSA-N |
| LogP | 4.130 (est) |
| CAS DataBase Reference | 35825-57-1(CAS DataBase Reference) |
| FDA UNII | 5E9SXT166N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H410 | |||||||||
| Precautionary statements | P273-P301+P310-P501 | |||||||||
| Hazard Codes | T,N | |||||||||
| Risk Statements | 25-50/53 | |||||||||
| Safety Statements | 45-60-61 | |||||||||
| RIDADR | UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | SF8282645 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29321900 | |||||||||
| NFPA 704 |
|
Cryptotanshinone price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL89612 | Cryptotanshinone phyproof? Reference Substance | 35825-57-1 | 10MG | $584 | 2024-03-01 | Buy |
| TCI Chemical | C3363 | Cryptotanshinone >97.0%(HPLC) | 35825-57-1 | 25mg | $152 | 2024-03-01 | Buy |
| TCI Chemical | C3363 | Cryptotanshinone >97.0%(HPLC) | 35825-57-1 | 100mg | $303 | 2024-03-01 | Buy |
| Cayman Chemical | 16987 | Cryptotanshinone ≥95% | 35825-57-1 | 5mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 16987 | Cryptotanshinone ≥95% | 35825-57-1 | 10mg | $57 | 2024-03-01 | Buy |
Cryptotanshinone Chemical Properties,Uses,Production
Chemical Properties
Orange powder
Uses
Cryptotanshinone (CPT), a lipophilic diterpene derived from the roots of Salvia miltiorrhiza Bge and Salvia przewalskii Maxim, may be used to study its multiple bioactivities as an antibacterial, antidermatophytic, antioxidant, anti-inflammatory and anticancer agent. Cryptotanshinone may also be studied as a differentiation factor.
Uses
inhibits angiogenesis
Definition
ChEBI: Cryptotanshinone is an abietane diterpenoid. It has a role as an anticoronaviral agent.
General Description
Cryptotanshinone, a cell-permeable diterpene quinone and naturally occurring herbal constituent of Salvia miltiorrhiza Bunge (Danshen), is shown to inhibit the constitutive STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells (>90% inhibition in 1 h at 7 μM) independent of the IL-6/JAK/STAT3 signaling pathway, resulting in a blockage of STAT3 dimerization, nuclear translocation, and STAT3-dependent transcription activity (by ~80% in 24 h at 7 μM). Cryptotanshinone is also reported to deplete cellular ATP level (by 75% in 12 h at 20 μM in C2C12 myotubes), resulting in an indirect activation of cellular AMPK pathways and an enhancement of insulin-stimulated cellular glucose uptake in C2C12 myotubes and 3T3-L1 adipocytes (by ~1.3- and 1.9-fold, respectively). Cryptotanshinone is demonstrated to be an orally active hypoglycemic agent in ob/ob mice, db/db mice, and ZDF rats in vivo (600 mg/kg/day).
Biological Activity
Major tanshinone isolated from Salvia miltiorrhiza that exhibits multiple activities. Exhibits antitumor activity via inhibition STAT3 activity (IC 50 = 4.6 μ ). Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also improves cognitive impairment in Alzheimer's disease transgenic mice by inhibition of acetylcholinesterase (IC 50 = 4.09 μ ) and reduction in A β peptide generation.
Biochem/physiol Actions
Cryptotanshinone is an antibacterial and anti-inflammatory compound originally extracted from the roots of Salvia miltiorrhiaz (danshen). Cryptotanshinone has been found to inhibit HIF activation and to inhibit macrophage migration negatively regulate the PI3K pathway. It has demonstrated activity against several strains of Staphylococcus aureus.
Cytotoxicity
IC50 (μg/mL): 1.27 (A549), 1.39 (TOV-21G) (Chang et al. 2013)
storage
Room temperature
Cryptotanshinone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18775 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 | sale02@cqherb.com | CHINA | 376 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from Cryptotanshinone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-28 | Cryptotanshinone POWDER
35825-57-1
|
US $0.00-0.00 / Kg | 1Kg | 98% | 2000 | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2024-11-19 | Cryptotanshinone
35825-57-1
|
US $46.00-153.00 / mg | ≥95% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Cryptotanshinone
35825-57-1
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
-
- Cryptotanshinone POWDER
35825-57-1
- US $0.00-0.00 / Kg
- 98%
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Cryptotanshinone
35825-57-1
- US $46.00-153.00 / mg
- ≥95%
- TargetMol Chemicals Inc.
-
- Cryptotanshinone
35825-57-1
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.