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PSYCHOSINE

CAS No.
2238-90-6
Chemical Name:
PSYCHOSINE
Synonyms
PSYCHOSIN;PSYCHOSINE;PSYCHOSINE(RG);LYSO-CEREBROSIDE;PSYCHOSINE USP/EP/BP;Galactosylsphingosine;O-Galactosylsphingosine;Psychosine (free amine);Sphingosine galactoside;LYSO-CERAMIDEGALACTOSIDE
CBNumber:
CB4245038
Molecular Formula:
C24H47NO7
Molecular Weight:
461.63
MDL Number:
MFCD07374280
MOL File:
2238-90-6.mol
MSDS File:
SDS
Last updated:2024-10-30 18:52:02

PSYCHOSINE Properties

Melting point 190 °C (decomp)
Boiling point 664.3±55.0 °C(Predicted)
Density 1.14±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility Chloroform/Methanol/DI water (5:1:0.1): soluble; Ethanol: soluble
form lyophilized powder
pka 11.74±0.45(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H225-H301+H311+H331-H370
Precautionary statements  P210-P260-P280-P301+P310+P330-P308+P311-P370+P378-P403+P233
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  36
WGK Germany  3
NFPA 704
0
3 0

PSYCHOSINE price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P9256 Psychosine from bovine brain lyophilized powder, ≥98% (TLC) 2238-90-6 1mg $111 2024-03-01 Buy
Sigma-Aldrich P9256 Psychosine from bovine brain lyophilized powder, ≥98% (TLC) 2238-90-6 10mg $506 2024-03-01 Buy
Cayman Chemical 20338 Galactosylsphingosine (d18:1) ≥95% 2238-90-6 1mg $63 2024-03-01 Buy
Cayman Chemical 20338 Galactosylsphingosine (d18:1) ≥95% 2238-90-6 5mg $230 2024-03-01 Buy
Cayman Chemical 20338 Galactosylsphingosine (d18:1) ≥95% 2238-90-6 10mg $335 2024-03-01 Buy
Product number Packaging Price Buy
P9256 1mg $111 Buy
P9256 10mg $506 Buy
20338 1mg $63 Buy
20338 5mg $230 Buy
20338 10mg $335 Buy

PSYCHOSINE Chemical Properties,Uses,Production

Description

Galactosylsphingosine is a bioactive sphingolipid. It potentiates LPS-induced production of inflammatory cytokines, decreases the mitochondrial membrane potential, and induces cell death in mouse astrocytes, effects that can be reversed by the sphingosine-1-phosphate receptor agonist FTY720 phosphate . Galactosylsphingosine (0.1 and 1 μM) induces demyelination of mouse cerebellar slices. It inhibits PDGF-induced translocation of PKC to the cell surface and induces apoptosis in MO3.13 oligodendrocytes. Galactosylsphingosine (10 and 15 μM) inhibits gene transcription mediated by peroxisome proliferator-activated receptor α (PPARα) in reporter assays using C6 glial cells. Levels of galactosylsphingosine are increased in postmortem brain from patients with Krabbe disease, a lysosomal storage disorder characterized by a β-galactosylceramidase deficiency.[Matreya, LLC. Catalog No. 1305]

Uses

Psychosine is a cationic lysosphingolipid that displays neuroprotective effects against quisqualate.

Definition

ChEBI: A glycosylsphingoid consisting of sphingosine having a beta-D-galactosyl residue attached at the 1-position.

General Description

Galactosyl(β) Sphingosine (d18:1) is a substrate for the enzyme endoglycoceramidase I (EGCase I). It has sphingosine backbone with galactose attached to it and is a brain glycospingolipid.

Biochem/physiol Actions

Galatosylsphingosine or psychosine is a cytotoxic lipid which accumulates in oligodendrocytes due to dysfunctional lysosomal enzyme galactosylceramidase and is implicated in globoid cell leukodystrophy. Psychosine accumulation induces demyelination, astrocyte dysfunction and pro-inflammatory cytokine release in Krabbe disease.

Enzyme inhibitor

This cationic brain lysosphingolipid (FWfree-base = 461.64 g/mol; CAS 2238- 90-6), also known as 1-O-b-D-galactosylsphingosine, inhibits metabotropic a1-adrenergic receptor signaling-induced phospholipase C activation in rat brain astrocytes. Psychosine also exerts protective effects against quisqualate, suggesting it may be useful in prophylaxis of neurodegenerative disorders arising from over-stimulation of hippocampal Group 1 metabolotropic glutamate receptor, or mGluR. Psychosine is the product of the reaction catalyzed by sphingosine b-galactosyltransferase and is the substrate for psychosine sulfotransferase and galactosylceramidase. Target(s): cerebroside-sulfatase, or arylsulfatase A; cytochrome c oxidase; cytokinesis; electron transport; galactosylgalactosylglucosylceramidase; glucocerebrosidase, lysosome; b-glucosidase; phosphorylase kinase; protein kinase C (11- 14); protein-tyrosine sulfotransferase; and sphingomyelinase.

PSYCHOSINE Preparation Products And Raw materials

Raw materials

Preparation Products

PSYCHOSINE Suppliers

Global( 58)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 22883 58
Alfa Chemistry
Info@alfa-chemistry.com United States 24072 58
LEAPCHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 43340 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Shandong Xiya Chemical Co., Ltd 4009903999 13355009207 3007715519@qq.com China 18738 57
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-400-6206333 18521732826 market@aladdin-e.com China 25003 65
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969 isunpharm@qq.com China 4428 55
Yichang Zhongyitai Trading Co., Ltd. 0717-6449896 13886658719 root@zhongyitai.com China 1977 58

View Lastest Price from PSYCHOSINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Psychosine pictures 2024-10-29 Psychosine
2238-90-6
US $0.00 / removed 10g TargetMol Chemicals Inc.
  • Psychosine pictures
  • Psychosine
    2238-90-6
  • US $0.00 / removed
  • TargetMol Chemicals Inc.
PSYCHOSINE 1-BETA-D-GALACTOSYLSPHINGOSINE 1-B-D-GALACTOSYLSPHINOGOSINE LYSO-CERAMIDEGALACTOSIDE LYSO-CEREBROSIDE D-GALACTOSYL-B1-1'-D-ERYTHRO-SPHINGOSINE D-GALACTOSYL-B1-1' SPHINGOSINE D-GALACTOSYL-B1-1' SPHINGOSN 1-β-d-galactosylsphingosine (2R,3R,4S,5S,6R)-2-[(E,2S,3R)-2-amino-3-hydroxy-octadec-4-enoxy]-6-(hydroxymethyl)oxane-3,4,5-triol Galactosylsphingosine PSYCHOSINE(RG) (2S,3R,4E)-1-(β-D-Galactopyranosyloxy)-2-amino-4-octadecene-3-ol [(2S,3R,4E)-2-Amino-3-hydroxy-4-octadecenyl]β-D-galactopyranoside 1-O-β-D-Galactopyranosylsphingosine O-Galactosylsphingosine PEONIDIN-3-O-GALACTOSIDE CHLORIDE(RG) D-galactosyl-1-1'-D-erythro-sphingosine Psychosine (Galactosylsphingosine) SPHINGOSYL-BETA-D-GALACTOPYRANOSIDE SPHINGOSINE, 1-BETA-D-GALACTOSYL PSYCHOSIN Galactosylsphingosine (d18:1) β-D-Galactopyranoside, (2S,3R,4E)-2-amino-3-hydroxy-4-octadecen-1-yl Galactosyl(beta) Sphingosine (d18:1) Psychosine Quantitative Mass Spec Standard PSYCHOSINE USP/EP/BP D-galactosyl-β1-1'-D-erythro-sphingosine Psychosine (free amine) b-D-Galactosylsphingosine - Synthetic Sphingosine galactoside Galactosylsphingosine (d18:1) (synthetic) D-galactosyl-β1-1'-D-erythro-sphingosine Galactosyl(β) Sphingosine (d18:1) 2238-90-6 C24H47NO7 BioChemical Metabolomics Metabolic Libraries Lipid Library Miscellaneous Natural Products