PSYCHOSINE
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PSYCHOSINE 속성
- 녹는점
- 190 °C (decomp)
- 끓는 점
- 664.3±55.0 °C(Predicted)
- 밀도
- 1.14±0.1 g/cm3(Predicted)
- 저장 조건
- -20°C
- 용해도
- Chloroform/Methanol/DI water (5:1:0.1): soluble; Ethanol: soluble
- 물리적 상태
- 동결건조된 분말
- 산도 계수 (pKa)
- 11.74±0.45(Predicted)
- 색상
- White to off-white
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
PSYCHOSINE C화학적 특성, 용도, 생산
개요
Galactosylsphingosine is a bioactive sphingolipid. It potentiates LPS-induced production of inflammatory cytokines, decreases the mitochondrial membrane potential, and induces cell death in mouse astrocytes, effects that can be reversed by the sphingosine-1-phosphate receptor agonist FTY720 phosphate . Galactosylsphingosine (0.1 and 1 μM) induces demyelination of mouse cerebellar slices. It inhibits PDGF-induced translocation of PKC to the cell surface and induces apoptosis in MO3.13 oligodendrocytes. Galactosylsphingosine (10 and 15 μM) inhibits gene transcription mediated by peroxisome proliferator-activated receptor α (PPARα) in reporter assays using C6 glial cells. Levels of galactosylsphingosine are increased in postmortem brain from patients with Krabbe disease, a lysosomal storage disorder characterized by a β-galactosylceramidase deficiency.[Matreya, LLC. Catalog No. 1305]용도
Psychosine is a cationic lysosphingolipid that displays neuroprotective effects against quisqualate.정의
ChEBI: A glycosylsphingoid consisting of sphingosine having a beta-D-galactosyl residue attached at the 1-position.일반 설명
Galactosyl(β) Sphingosine (d18:1) is a substrate for the enzyme endoglycoceramidase I (EGCase I). It has sphingosine backbone with galactose attached to it and is a brain glycospingolipid.효소 저해제
This cationic brain lysosphingolipid (FWfree-base = 461.64 g/mol; CAS 2238- 90-6), also known as 1-O-b-D-galactosylsphingosine, inhibits metabotropic a1-adrenergic receptor signaling-induced phospholipase C activation in rat brain astrocytes. Psychosine also exerts protective effects against quisqualate, suggesting it may be useful in prophylaxis of neurodegenerative disorders arising from over-stimulation of hippocampal Group 1 metabolotropic glutamate receptor, or mGluR. Psychosine is the product of the reaction catalyzed by sphingosine b-galactosyltransferase and is the substrate for psychosine sulfotransferase and galactosylceramidase. Target(s): cerebroside-sulfatase, or arylsulfatase A; cytochrome c oxidase; cytokinesis; electron transport; galactosylgalactosylglucosylceramidase; glucocerebrosidase, lysosome; b-glucosidase; phosphorylase kinase; protein kinase C (11- 14); protein-tyrosine sulfotransferase; and sphingomyelinase.PSYCHOSINE 준비 용품 및 원자재
원자재
준비 용품
PSYCHOSINE 공급 업체
글로벌( 59)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 24330 | 58 |
Alfa Chemistry | |
Info@alfa-chemistry.com | United States | 24072 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 43348 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
Shandong Xiya Chemical Co., Ltd | 4009903999 13355009207 |
3007715519@qq.com | China | 18738 | 57 |
Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-400-6206333 18521732826 |
market@aladdin-e.com | China | 25013 | 65 |
Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 |
isunpharm@qq.com | China | 4428 | 55 |
Yichang Zhongyitai Trading Co., Ltd. | 0717-6449896 13886658719 |
root@zhongyitai.com | China | 1977 | 58 |
PSYCHOSINE 관련 검색:
PSYCHOSINE
PSYCHOSINE
N-ACETYL-PSYCHOSINE, C2-CEREBROSIDE,N-ACETYL-PSYCHOSINE
D-ERYTHRO-SPHINGOSINE
N-STEAROYL-D35-PSYCHOSINE
N-Pentadecanoyl-psychosine?
N-STEAROYL-PSYCHOSINE
BODIPY(R) FL C12-GALACTOCEREBROSIDE
GALACTOSYL CERAMIDE, [GALACTOSE-6-3H]
PSYCHOSINE, [GALACTOSE-6-3H]
psychosine-3'-sulfate ester
Psychosine from bovine brain
2,3,4,6-TETRA-O-ACETYL-BETA-D-GALACTOPYRANOSY(1-4)-2,3,6-TRI-O-ACETYL-BETA-D-GLUCOPYRANOSYL CERAMIDE
TNPAL-GALACTOCEREBROSIDE
C6 NBD GALACTOSYL CERAMIDE
C24:0-SULFATIDE
N-STEAROYL-D35-PSYCHOSINE, PERDEUTERATED
PSYCHOSINE, N-ACETYL