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()-AS 115

()-AS 115 Structure
()-AS 115 structure
CAS No.
926657-43-4
Chemical Name:
()-AS 115
Synonyms
()-AS 115;BTYYXSHZANWPEB-ZWKOTPCHSA-N;Carbamic acid, N-[2-[[(1R,2S)-2-(butoxymethyl)cyclohexyl]methoxy]ethyl]-, 2-fluorophenyl ester, rel-
CBNumber:
CB42589767
Molecular Formula:
C21H32FNO4
Molecular Weight:
381.48
MDL Number:
MOL File:
926657-43-4.mol
Last updated:2023-06-08 09:02:11
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()-AS 115 Properties

solubility DMF: 12 mg/ml; DMSO: 12 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07
Signal word  Danger
NFPA 704
3
2 0

()-AS 115 price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 13250 (?)-AS 115 ≥98% 926657-43-4 100μg $60 2024-03-01 Buy
Cayman Chemical 13250 (?)-AS 115 ≥98% 926657-43-4 500μg $259 2024-03-01 Buy
Cayman Chemical 13250 (?)-AS 115 ≥98% 926657-43-4 1mg $457 2024-03-01 Buy
AK Scientific 1002AH N-[2-[[(1R,2S)-2-(butoxymethyl)cyclohexyl]methoxy]ethyl]-2-fluorophenylester-carbamicacid 926657-43-4 1mg $607 2021-12-16 Buy
Product number Packaging Price Buy
13250 100μg $60 Buy
13250 500μg $259 Buy
13250 1mg $457 Buy
1002AH 1mg $607 Buy

()-AS 115 Chemical Properties,Uses,Production

Description

KIAA1363 is a 2-acetyl monoacylglyceryl ether (MAGE) hydrolase that is upregulated in aggressive cancers from various tissues.1 The enzyme catalyzes the hydrolysis of the 2-acetyl MAGE to MAGE and serves as a central enzyme in the PAF and LPA signaling network.2 AS 115 is a potent and selective inactivator of KIAA1363, displaying an IC50 value of 150 nM when tested as a racemic mixture in the invasive ovarian cancer cell line SKOV3.2 Treatment of SKOV3 cells with 10 μM AS-115 for 4 hours significantly reduced the formation of MAGE, alkyl-lysophosphatidylcholine, and alkyl-lysophosphatidic acid. The activity of the individual enantiomers of AS 115, i.e. (+)-AS 115 and (?)-AS 115, has not been determined.

References

1. Jessani, N., Liu, Y., Humphrey, M., et al. Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness Proc. Natl. Acad. Sci. USA 99(16),10335-10340(2002).
2. Chiang, K.P., Niessen, S., Saghatelian, A., et al. An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling Chem. Biol. 13(10),1041-1050(2006).

()-AS 115 Preparation Products And Raw materials

Raw materials

Preparation Products

()-AS 115 Suppliers

Global( 10)Suppliers
Supplier Tel Email Country ProdList Advantage
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998 757984502@qq.com China 892 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9707 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
ShangHai ChuanQian Chemcial Technique Centre 15869524721 3525679403@qq.com China 3670 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 024-024-88590548 18341751992 757984502@qq.com China 892 58
Supplier Advantage
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		58
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
ShangHai ChuanQian Chemcial Technique Centre 58
MedBioPharmaceutical Technology Inc 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 58
()-AS 115 BTYYXSHZANWPEB-ZWKOTPCHSA-N Carbamic acid, N-[2-[[(1R,2S)-2-(butoxymethyl)cyclohexyl]methoxy]ethyl]-, 2-fluorophenyl ester, rel- 926657-43-4 C21H32FNO4