()-AS 115
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- $60 - $607
- Product name: ()-AS 115
- CAS: 926657-43-4
- MF: C21H32FNO4
- MW: 381.48
- EINECS:
- MDL Number:
- Synonyms:()-AS 115;BTYYXSHZANWPEB-ZWKOTPCHSA-N;Carbamic acid, N-[2-[[(1R,2S)-2-(butoxymethyl)cyclohexyl]methoxy]ethyl]-, 2-fluorophenyl ester, rel-
4 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
Package
- 100μg
- 500μg
- 1mg
- ManufacturerAK Scientific
- Product number1002AH
- Product descriptionN-[2-[[(1R,2S)-2-(butoxymethyl)cyclohexyl]methoxy]ethyl]-2-fluorophenylester-carbamicacid
- Packaging1mg
- Price$607
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13250
- Product description(?)-AS 115 ≥98%
- Packaging100μg
- Price$60
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13250
- Product description(?)-AS 115 ≥98%
- Packaging500μg
- Price$259
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13250
- Product description(?)-AS 115 ≥98%
- Packaging1mg
- Price$457
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 1002AH | N-[2-[[(1R,2S)-2-(butoxymethyl)cyclohexyl]methoxy]ethyl]-2-fluorophenylester-carbamicacid | 1mg | $607 | 2021-12-16 | Buy |
| Cayman Chemical | 13250 | (?)-AS 115 ≥98% | 100μg | $60 | 2024-03-01 | Buy |
| Cayman Chemical | 13250 | (?)-AS 115 ≥98% | 500μg | $259 | 2024-03-01 | Buy |
| Cayman Chemical | 13250 | (?)-AS 115 ≥98% | 1mg | $457 | 2024-03-01 | Buy |
Properties
solubility :DMF: 12 mg/ml; DMSO: 12 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
Safety Information
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| Signal word: | Danger | |||||||
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Description
KIAA1363 is a 2-acetyl monoacylglyceryl ether (MAGE) hydrolase that is upregulated in aggressive cancers from various tissues. The enzyme catalyzes the hydrolysis of the 2-acetyl MAGE to MAGE and serves as a central enzyme in the PAF and LPA signaling network. AS 115 is a potent and selective inactivator of KIAA1363, displaying an IC50 value of 150 nM when tested as a racemic mixture in the invasive ovarian cancer cell line SKOV3. Treatment of SKOV3 cells with 10 μM AS-115 for 4 hours significantly reduced the formation of MAGE, alkyl-lysophosphatidylcholine, and alkyl-lysophosphatidic acid. The activity of the individual enantiomers of AS 115, i.e. (+)-AS 115 and (?)-AS 115, has not been determined.Suppliers and manufacturers
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