Q-VD-OPh hydrate
- CAS No.
- 1135695-98-5
- Chemical Name:
- Q-VD-OPh hydrate
- Synonyms
- CS-2734;Q-VD-OPh hydrate;Q-VD-OPh (QVD-OPH;Quinoline-Val-Asp-Difluorophenoxymethylketone);QVD-OPH;QUINOLINE-VAL-ASP-DIFLUOROPHENOXYMETHYLKETONE;QVD-OPH,QVDOPH,inhibit,Caspase,Human immunodeficiency virus,Inhibitor,HIV,Q VD OPH;(3S)-5-(2,6-Difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoic acid;Pentanoic acid, 5-(2,6-difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-, (3S)-;(3S)-5-(2,6-Difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoic acid hydrate
- CBNumber:
- CB42652283
- Molecular Formula:
- C26H25F2N3O6
- Molecular Weight:
- 513.49
- MDL Number:
- MFCD08669741
- MOL File:
- 1135695-98-5.mol
Boiling point | 808.9±65.0 °C(Predicted) |
---|---|
Density | 1.346±0.06 g/cm3 (20 ºC 760 Torr) |
storage temp. | -20°C |
solubility | DMSO: ≥14mg/mL |
pka | 3.92±0.19(Predicted) |
form | powder |
color | white to light brown |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
InChIKey | OOBJCYKITXPCNS-REWPJTCUSA-N |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
WGK Germany | 3 |
Q-VD-OPh hydrate price More Price(24)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML0063 | Q-VD-OPh hydrate ≥95% (HPLC) | 1135695-98-5 | 1mg | $258 | 2024-03-01 | Buy |
Sigma-Aldrich | SML0063 | Q-VD-OPh hydrate ≥95% (HPLC) | 1135695-98-5 | 5mg | $1030 | 2024-03-01 | Buy |
Cayman Chemical | 15260 | Q-VD-OPH ≥95% (mixture of tautomers) | 1135695-98-5 | 1mg | $121 | 2024-03-01 | Buy |
Cayman Chemical | 15260 | Q-VD-OPH ≥95% (mixture of tautomers) | 1135695-98-5 | 5mg | $423 | 2024-03-01 | Buy |
TRC | D446120 | (3S)-5-(2,6-Difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoicAcid | 1135695-98-5 | 25mg | $1260 | 2021-12-16 | Buy |
Q-VD-OPh hydrate Chemical Properties,Uses,Production
Description
Q-VD-OPH is a broad-spectrum caspase inhibitor, blocking caspases-3, -7, -8, -9, -10, and -12 and inhibiting apoptosis when used at 10 μM. It more effectively inhibits apoptosis and is much less cytotoxic than Z-VAD-FMK and Boc-D-FMK . Q-VD-OPH can be used in vivo, where it has been shown to prevent ischemia-reperfusion injury-induced apoptosis. This compound, by broadly inhibiting caspases, also promotes the differentiation of leukemic blasts cells, suggesting an application in differentiation therapy of certain forms of cancer.
Uses
An inhibitor that is used in Alzheimer’s studies relating to caspase-6, the cysteinyl protease involved in neurodegenerative conditions. As well it is an intermediate in the formation of Palinavir, a potent HIV protease inhibitor.
Uses
Q-VD-OPh hydrate has been used:
- as a pan-caspase inhibitor to prevent cell death in urothelial carcinoma cells (UCC)
- to induce canonical caspase-dependent apoptosis in UC cells
- to block caspase-3 and Poly (ADP-ribose) polymerase-1 (PARP-1)
- to study the protective role of EspZ effector protein against apoptosis and necrosis in human epithelial cells
Biochem/physiol Actions
Q-VD-OPh is a potent pan-caspase inhibitor that protects cells from capsase-dependent apoptosis. Q-VD-OPh has superior aqueous stability, cell permeability, and efficacy than FMK-based caspase inhibitors and displays no cytotoxic effects alone.
target
caspase-1
storage
+4°C
References
1) Caserta?et al.?(2003),?Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties; Apoptosis,?8?345 2) Braun?et al.?(2007),?Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH; Exp. Neurol.,?206?183 3) Rebbaa?et al.?(2003),?Caspase inhibition switches doxorubicin-induced apoptosis to senescence; Oncogene,?22?2805 4) Bulatovic?et al.?(2015),?Sublethal caspase activation promotes generation of cardiomyocytes from embryonic stem cells; PLoS One,?10?e0120176 5) Bailey?et al. (2017),?Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis;?Cell Death Dis.,?8?e2590
Q-VD-OPh hydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Q-VD-OPh hydrate Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29824 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
View Lastest Price from Q-VD-OPh hydrate manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-12-20 | Q-VD-OPh hydrate
1135695-98-5
|
US $1.00 / g | 1g | 99.99% | 2tons | Career Henan Chemical Co |
- Q-VD-OPh hydrate
1135695-98-5
- US $1.00 / g
- 99.99%
- Career Henan Chemical Co
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