N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
- CAS No.
- 211311-95-4
- Chemical Name:
- N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
- Synonyms
- 100775;CS-2739;LY40418;LY404187;LY-404187; LY 404187;N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide;N-2-(4-(4-Cyanophenyl)phenyl)propyl-2-propanesulfonamide;N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonamide;N-[2-[4-(4-Cyanophenyl)phenyl]propyl]propane-2-sulfonamide;N-[2-(4'-Cyano[1,1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide
- CBNumber:
- CB42640286
- Molecular Formula:
- C19H22N2O2S
- Molecular Weight:
- 342.46
- MDL Number:
- MFCD07364003
- MOL File:
- 211311-95-4.mol
- MSDS File:
- SDS
Boiling point | 519.0±60.0 °C(Predicted) |
---|---|
Density | 1.19±0.1 g/cm3(Predicted) |
storage temp. | Sealed in dry,Room Temperature |
solubility | DMF: 15mg/mL; DMSO: 15mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL; Ethanol: 3mg/mL |
form | A solid |
pka | 11.24±0.40(Predicted) |
color | White to off-white |
FDA UNII | 75W6I8W6OU |
N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide price More Price(23)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 28741 | LY404187 | 211311-95-4 | 5mg | $110 | 2024-03-01 | Buy |
Cayman Chemical | 28741 | LY404187 | 211311-95-4 | 50mg | $542 | 2024-03-01 | Buy |
Cayman Chemical | 28741 | LY404187 | 211311-95-4 | 10mg | $175 | 2024-03-01 | Buy |
Cayman Chemical | 28741 | LY404187 | 211311-95-4 | 25mg | $352 | 2024-03-01 | Buy |
Tocris | 5297 | LY404187 ≥98%(HPLC) | 211311-95-4 | 10 | $210 | 2021-12-16 | Buy |
N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Chemical Properties,Uses,Production
Description
LY404187 is a benzothiadiazide positive allosteric modulator of AMPA receptors. It increases glutamate-induced activation of GluR1i, -2i, -2o, -3i, and -4i subunit-containing AMPA receptors with EC50 values of 5.65, 0.15, 1.44, 1.66, and 0.21 μM, respectively, in a calcium influx assay. LY404187 is selective for these AMPA receptors over GluR6 subunit-containing kainate receptors at 10 μM. LY404187 increases currents induced by glutamate and AMPA in rat prefrontal cortex pyramidal neurons (EC50s = 1.3 and 1.2 μM, respectively) but not in AMPA-stimulated primary rat embryonic hippocampal or primary cerebellar Purkinje neurons. LY404187 prevents decreases in the number of dopaminergic neurons in the substantia nigra induced by MPTP and 6-OHDA in mouse and rat, respectively, models of Parkinson’s disease when administered at a dose of 0.5 mg/kg per day.
Uses
LY 404187 is a novel positive allosteric modulator of AMPA receptors.
storage
Store at +4°C
N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Preparation Products And Raw materials
Raw materials
Preparation Products
N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
ChemShuttle, Inc. | 0510-83588313-802 18800520310; | sales@chemshuttle.com | China | 2996 | 62 |
AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
CEG Chemical Science&Technology Co., Ltd. | Mobile:13665161512 | China | 1785 | 58 | |
Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9798 | 50 |
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