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N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide

化学構造式
211311-95-4
CAS番号.
211311-95-4
化学名:
别名:
英語名:
N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
英語别名:
100775;CS-2739;LY40418;LY404187;LY-404187; LY 404187;N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide;N-2-(4-(4-Cyanophenyl)phenyl)propyl-2-propanesulfonamide;N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonamide;N-[2-[4-(4-Cyanophenyl)phenyl]propyl]propane-2-sulfonamide;N-[2-(4'-Cyano[1,1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide
CBNumber:
CB42640286
化学式:
C19H22N2O2S
分子量:
342.46
MOL File:
211311-95-4.mol

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide 物理性質

沸点 :
519.0±60.0 °C(Predicted)
比重(密度) :
1.19±0.1 g/cm3(Predicted)
貯蔵温度 :
Sealed in dry,Room Temperature
溶解性:
DMF: 15mg/mL; DMSO: 15mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL; Ethanol: 3mg/mL
外見 :
A solid
酸解離定数(Pka):
11.24±0.40(Predicted)
色:
White to off-white

安全性情報

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide 化学特性,用途語,生産方法

説明

LY404187 is a benzothiadiazide positive allosteric modulator of AMPA receptors. It increases glutamate-induced activation of GluR1i, -2i, -2o, -3i, and -4i subunit-containing AMPA receptors with EC50 values of 5.65, 0.15, 1.44, 1.66, and 0.21 μM, respectively, in a calcium influx assay. LY404187 is selective for these AMPA receptors over GluR6 subunit-containing kainate receptors at 10 μM. LY404187 increases currents induced by glutamate and AMPA in rat prefrontal cortex pyramidal neurons (EC50s = 1.3 and 1.2 μM, respectively) but not in AMPA-stimulated primary rat embryonic hippocampal or primary cerebellar Purkinje neurons. LY404187 prevents decreases in the number of dopaminergic neurons in the substantia nigra induced by MPTP and 6-OHDA in mouse and rat, respectively, models of Parkinson’s disease when administered at a dose of 0.5 mg/kg per day.

使用

LY 404187 is a novel positive allosteric modulator of AMPA receptors.

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide 上流と下流の製品情報

原材料

準備製品

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide 生産企業

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  スペクトルデータ(1HNMR)

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide(211311-95-4)1HNMR

211311-95-4()キーワード:

イソプロピルビフェニル 3-(1-メチル-1H-ピラゾール-4-イル)-5-オキソ-N-(2-ピリジニルメチル)-5H-ベンゾ[4,5]シクロヘプタ[1,2-B]ピリジン-7-メタンスルホンアミド BIBR-1532 ウパダシチニブ EZSOLUTION™ Q-VD-OPH リトレシチニブ 2-(2-((4-ブロモフェニル)アミノ)-2-オキソエトキシ)-N-(2-(メチル(フェニル)アミノ)-2-オキソエチル)ベンズアミド (S)-4-(4-((2-(3,5-ジメチルフェニル)ピロリジン-1-イル)メチル)フェノキシ)-3-フルオロベンズアミド リンロドスタット アバコパン
  • 211311-95-4
  • N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
  • LY404187
  • N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonaMide
  • N-[2-(4'-Cyano[1,1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide
  • N-2-(4-(4-Cyanophenyl)phenyl)propyl-2-propanesulfonamide
  • LY-404187 N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
  • CS-2739
  • 100775
  • LY-404187; LY 404187
  • 2-Propanesulfonamide, N-[2-(4'-cyano[1,1'-biphenyl]-4-yl)propyl]-
  • N-[2-[4-(4-Cyanophenyl)phenyl]propyl]propane-2-sulfonamide
  • GluR2o,inhibit,Allosteric,GluR3i,iGluR,GluR4i,AMPA,Ionotropic glutamate receptors,GluR1i,LY-404187,psychiatric,LY404187,Inhibitor,GluR2i,LY 404187,neurodegenerative
  • LY40418
  • N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonamide
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