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ChemicalBook >제품 카탈로그 >N-(2-(4'-시아노비페닐-4-일)프로필)프로판-2-설폰아미드

N-(2-(4'-시아노비페닐-4-일)프로필)프로판-2-설폰아미드

N-(2-(4'-시아노비페닐-4-일)프로필)프로판-2-설폰아미드
N-(2-(4'-시아노비페닐-4-일)프로필)프로판-2-설폰아미드 구조식 이미지
카스 번호:
211311-95-4
한글명:
N-(2-(4'-시아노비페닐-4-일)프로필)프로판-2-설폰아미드
동의어(한글):
N-(2-(4'-시아노비페닐-4-일)프로필)프로판-2-설폰아미드
상품명:
N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
동의어(영문):
100775;CS-2739;LY40418;LY404187;LY-404187; LY 404187;N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide;N-2-(4-(4-Cyanophenyl)phenyl)propyl-2-propanesulfonamide;N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonamide;N-[2-[4-(4-Cyanophenyl)phenyl]propyl]propane-2-sulfonamide;N-[2-(4'-Cyano[1,1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide
CBNumber:
CB42640286
분자식:
C19H22N2O2S
포뮬러 무게:
342.46
MOL 파일:
211311-95-4.mol

N-(2-(4'-시아노비페닐-4-일)프로필)프로판-2-설폰아미드 속성

끓는 점
519.0±60.0 °C(Predicted)
밀도
1.19±0.1 g/cm3(Predicted)
저장 조건
Sealed in dry,Room Temperature
용해도
DMF: 15mg/mL; DMSO: 15mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL; Ethanol: 3mg/mL
물리적 상태
고체
산도 계수 (pKa)
11.24±0.40(Predicted)
색상
White to off-white

안전

N-(2-(4'-시아노비페닐-4-일)프로필)프로판-2-설폰아미드 C화학적 특성, 용도, 생산

개요

LY404187 is a benzothiadiazide positive allosteric modulator of AMPA receptors. It increases glutamate-induced activation of GluR1i, -2i, -2o, -3i, and -4i subunit-containing AMPA receptors with EC50 values of 5.65, 0.15, 1.44, 1.66, and 0.21 μM, respectively, in a calcium influx assay. LY404187 is selective for these AMPA receptors over GluR6 subunit-containing kainate receptors at 10 μM. LY404187 increases currents induced by glutamate and AMPA in rat prefrontal cortex pyramidal neurons (EC50s = 1.3 and 1.2 μM, respectively) but not in AMPA-stimulated primary rat embryonic hippocampal or primary cerebellar Purkinje neurons. LY404187 prevents decreases in the number of dopaminergic neurons in the substantia nigra induced by MPTP and 6-OHDA in mouse and rat, respectively, models of Parkinson’s disease when administered at a dose of 0.5 mg/kg per day.

용도

LY 404187 is a novel positive allosteric modulator of AMPA receptors.

N-(2-(4'-시아노비페닐-4-일)프로필)프로판-2-설폰아미드 준비 용품 및 원자재

원자재

준비 용품

N-(2-(4'-시아노비페닐-4-일)프로필)프로판-2-설폰아미드 공급 업체

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N-(2-(4'-시아노비페닐-4-일)프로필)프로판-2-설폰아미드 관련 검색:

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