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Decernotinib

CAS No.
944842-54-0
Chemical Name:
Decernotinib
Synonyms
VX 509;CS-1650;adelatinib;VRT 831509;Decernotinib;VX-509;VRT-831509;Decernotinib(VX-509);VX-509;? VRT-831509; ADELATINIB;Decernotinib (VX-509,adelatinib);(R)-2-((2-(1H-Pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-2-methyl-N-(2,2,2-trifluoroethyl)butanamide
CBNumber:
CB42718363
Molecular Formula:
C18H19F3N6O
Molecular Weight:
392.38
MDL Number:
MFCD27987896
MOL File:
944842-54-0.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33

Decernotinib Properties

Density 1.363±0.06 g/cm3(Predicted)
storage temp. 4°C, protect from light, stored under nitrogen
solubility insoluble in H2O; ≥16.95 mg/mL in DMSO; ≥2.92 mg/mL in EtOH with ultrasonic
form solid
pka 12.36±0.40(Predicted)
color White to off-white
FDA UNII MZK2GP0RHK

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319-H302-H335-H315
Precautionary statements  P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
NFPA 704
0
2 0

Decernotinib price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 19513 VX-509 ≥98% 944842-54-0 1mg $36 2024-03-01 Buy
Cayman Chemical 19513 VX-509 ≥98% 944842-54-0 5mg $120 2024-03-01 Buy
Cayman Chemical 19513 VX-509 ≥98% 944842-54-0 10mg $172 2024-03-01 Buy
Cayman Chemical 19513 VX-509 ≥98% 944842-54-0 25mg $384 2024-03-01 Buy
TRC D225580 Decernotinib 944842-54-0 50mg $375 2021-12-16 Buy
Product number Packaging Price Buy
19513 1mg $36 Buy
19513 5mg $120 Buy
19513 10mg $172 Buy
19513 25mg $384 Buy
D225580 50mg $375 Buy

Decernotinib Chemical Properties,Uses,Production

Uses

Decernotinib is a potent and selective Janus kinase 3 inhibitor for treatment of autoimmune diseases.

Biological Activity

decernotinib(vx-509)is a novel, potent and selective inhibitor of jak3 with ki value of 2 nm [1].the janus kinase family consists of four members: jak1, jak2, jak3, and tyk2. janus kinase 3 (jak3) is mainly expressed in lymphocytes, which are cells important to the immune response associated with many diseases, including rheumatoid arthritis (ra) [1].decernotinib(vx-509)is a novel, potent, selective and orally available jak3 inhibitor for the treatment of autoimmune diseases. vx-509 inhibited jak1, jak2, jak3, and tyk2 with ki values of 11, 13, 2 and 11 nm, respectively. in ht-2 or tf-1 cells, vx-509 inhibited jak3/1- or jak2-mediated phosphorylation of stat5 following stimulation with il-2 or gmcsf with ic50 values of 99 and 2600 nm, respectively [1].in the rat host versus graft (hvg) model, vx-509 at 50 mg/kg bid or 100 mg/kg qd significantly and dose-dependently inhibited popletial lymph node (pln) hyperplasia by 66% and 94%, respectively, relative to cyclosporin a (csa). vx-509 also significantly reduced cd25 expression. these results suggested that vx-509 showed significant dose-dependent immunosuppressive activity and effectively inhibited t-cell activation [1]. in the rat collagen-induced arthritis model, vx-509 dose-dependently reduced ankle swelling and paw weight, and improved paw histopathology scores. in oxazolone-induced delayed-type hypersensitivity mouse model, vx-509 reduced the t cell-mediated inflammatory response in skin [2].

References

[1]. farmer lj, ledeboer mw, hoock t, et al. discovery of vx-509 (decernotinib): a potent and selective janus kinase 3 inhibitor for the treatment of autoimmune diseases. j med chem, 2015, 58(18): 7195-7216.
[2]. mahajan s, hogan jk, shlyakhter d, et al. vx-509 (decernotinib) is a potent and selective janus kinase 3 inhibitor that attenuates inflammation in animal models of autoimmune disease. j pharmacol exp ther, 2015, 353(2): 405-414.

Decernotinib Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 84)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29882 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Baoji Guokang Bio-Technology Co., Ltd.
0917-3909592 13892490616 gksales1@gk-bio.com China 9314 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054 trendseenbio@gmail.com China 11681 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 10986 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Suzhou ARTK Medchem Co., Ltd.
+86-512-68323658 +86-18168183658 sales1@artkmedchem.com China 39004 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131957 58

View Lastest Price from Decernotinib manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Decernotinib pictures 2024-11-19 Decernotinib
944842-54-0
US $44.00-96.00 / mg 99.45% 10g TargetMol Chemicals Inc.
Decernotinib pictures 2021-07-13 Decernotinib
944842-54-0
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
Decernotinib pictures 2021-07-10 Decernotinib
944842-54-0
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
  • Decernotinib pictures
  • Decernotinib
    944842-54-0
  • US $44.00-96.00 / mg
  • 99.45%
  • TargetMol Chemicals Inc.
  • Decernotinib pictures
  • Decernotinib
    944842-54-0
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
  • Decernotinib pictures
  • Decernotinib
    944842-54-0
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

Decernotinib Spectrum

Decernotinib Decernotinib(VX-509) (R)-2-((2-(1H-Pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-2-methyl-N-(2,2,2-trifluoroethyl)butanamide (2R)-2-Methyl-2-[[2-(1H-pyrrolo[2,3-b]pyridin-3-yl)-4-pyrimidinyl]amino]-N-(2,2,2-trifluoroethyl)butanamide VRT 831509 VX 509 Butanamide, 2-methyl-2-[[2-(1H-pyrrolo[2,3-b]pyridin-3-yl)-4-pyrimidinyl]amino]-N-(2,2,2-trifluoroethyl)-, (2R)- adelatinib VX-509;? VRT-831509; ADELATINIB CS-1650 Decernotinib (VX-509,adelatinib) VX-509;VRT-831509 944842-54-0 C18H19F3N6O Inhibitors