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SU 6668

SU 6668 structure

CAS No.: 210644-62-5

Chemical Name:: SU 6668

Synonyms: SU 6668;(Z)-SU6668;(Z)-TSU-68;(Z)-Orantinib;(Z)-Orantinib/SU6668/TSU-68);PDGFR Tyrosine Kinase Inhibitor VI, SU6668;PDGFR Tyrosine Kinase Inhibitor VI, SU6668 - CAS 210644-62-5 - Calbiochem;3-[2,4-dimethyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoicacid;3-(2,4-Dimethyl-5-{[(3Z)-2-oxo-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid;3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl)-propionic acid

CBNumber:: CB91312244

Molecular Formula:: C18H18N2O3

Molecular Weight:: 310.35

MDL Number:: MFCD09743433

MOL File:: 210644-62-5.mol

Last updated:2024-07-02 08:55:40

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SU 6668 Properties

storage temp.	+2C to +8C
solubility	DMSO : 50 mg/mL (161.11 mM; Need ultrasonic)
form	Dark yellow solid
color	Orange to red
NCI Dictionary of Cancer Terms	SU6668

SU 6668 price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	CDS023028	2,4-Dimethyl-5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-pyrrole-3-propanoic acid	210644-62-5	100MG	$308	2023-01-07	Buy
Tocris	3335	SU6668 ≥99%(HPLC)	210644-62-5	10	$208	2021-12-16	Buy
TRC	D457088	(Z)-3-(2,4-Dimethyl-5-((2-oxoindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoicacid(SU-6668)	210644-62-5	5mg	$90	2021-12-16	Buy
Usbiological	256776	SU 6668	210644-62-5	10mg	$466	2021-12-16	Buy
Matrix Scientific	132613	(Z)-3-(2,4-Dimethyl-5-((2-oxoindolin-3-ylidene)-methyl)-1H-pyrrol-3-yl)propanoicacid 97%	210644-62-5	250mg	$537	2021-12-16	Buy

Product number	Packaging	Price	Buy
CDS023028	100MG	$308	Buy
3335	10	$208	Buy
D457088	5mg	$90	Buy
256776	10mg	$466	Buy
132613	250mg	$537	Buy

SU 6668 Chemical Properties,Uses,Production

Uses

PDGFR Tyrosine Kinase Inhibitor VI, SU6668 is a potent ATP-competitive inhibitor against tyrosine kinases.

General Description

A cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFRβ, VEGFR2 (Flk-1/KDR), FGFR1 activity in vitro (IC₅₀ = 0.01, 0.1, 3.9, and 3.8 μM, respectively) and PDGF/VEGF/bFGF-mediated angiogenesis and tumor development in vivo. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target ser/thr kinases Aurora A, Aurora B, TBK1 (NAK/T2K), and AMPK (IC₅₀ = 0.85, 0.047, 1.4, and 1.8 μM, respectively), as well as non-receptor TKs Lyn and Yes (IC₅₀ = 4.3 and 5.8 μM, respectively).

SU 6668 Preparation Products And Raw materials

Raw materials

Preparation Products

SU 6668 Suppliers

Global( 48)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Baoji Guokang Healthchem co.,ltd	+8615604608665 15604608665	dominicguo@gk-bio.com	CHINA	9427	58
Shaoxin Catsyn Co., Ltd.	+undefined-0575-82040869 +86-0575-82040869;	sales@catsyn.com	China	6116	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2923	55
Nanjing Chemlin Chemical Co., Ltd	025-83697070	info@chemlin.com.cn	China	18089	64
Nanjing JinruiJiuAn Biotechnology Co., Ltd.	025-58196018 800028039	sales@fartop.net	China	2231	55
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
SPIRO PHARMA		eric_feng1954@126.com	China	9254	55
Nanjing River Chemical Co., Ltd.	13951936332 18305166317	info@serpharm.com	China	494	55

Supplier	Advantage
Baoji Guokang Healthchem co.,ltd	58
Shaoxin Catsyn Co., Ltd.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Shanghai Boyle Chemical Co., Ltd.	55
Nanjing Chemlin Chemical Co., Ltd	64
Nanjing JinruiJiuAn Biotechnology Co., Ltd.	55
Sigma-Aldrich	80
SPIRO PHARMA	55
Nanjing River Chemical Co., Ltd.	55

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SU 6668 3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl)-propionic acid 1H-Pyrrole-3-propanoic acid, 5-((Z)-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl- 5-((Z)-1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-propanoic acid PDGFR Tyrosine Kinase Inhibitor VI, SU6668 3-[2,4-dimethyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoicacid PDGFR Tyrosine Kinase Inhibitor VI, SU6668 - CAS 210644-62-5 - Calbiochem 3-(2,4-Dimethyl-5-{[(3Z)-2-oxo-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid (Z)?-?3-?(2,?4-?Dimethyl-?5-?((2-?oxoindolin-?3-?ylidene)?methyl)?-?1H-?pyrrol-?3-?yl)?propanoic acid (SU-6668) (Z)-Orantinib (Z)-SU6668 (Z)-TSU-68 5-(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl-2,4-dimethyl-1H-pyrrol-3-propanoic acid (Z)-Orantinib/SU6668/TSU-68) 210644-62-5