1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole
![1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole Structure](CAS/20200119/GIF/337506-43-1.gif)
- CAS No.
- 337506-43-1
- Chemical Name:
- 1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole
- Synonyms
- BIM5078;BIM5078 Exclusive;BIM5078 >=98% (HPLC);1-(2-chloro-5-nitrophenyl)sulfonyl-2-methylbenzimidazole;1-(2′-Chloro-5′-nitrobenzenesulfonyl)-2-methylbenzimidazole;1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole;1H-Benzimidazole, 1-[(2-chloro-5-nitrophenyl)sulfonyl]-2-methyl-
- CBNumber:
- CB42751063
- Molecular Formula:
- C14H10ClN3O4S
- Molecular Weight:
- 351.76
- MDL Number:
- MFCD01173148
- MOL File:
- 337506-43-1.mol
1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0528 | BIM5078 ≥98% (HPLC) | 337506-43-1 | 5mg | $140 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0528 | BIM5078 ≥98% (HPLC) | 337506-43-1 | 25mg | $537 | 2024-03-01 | Buy |
| Cayman Chemical | 12031 | BIM5078 ≥98% | 337506-43-1 | 5mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 12031 | BIM5078 ≥98% | 337506-43-1 | 10mg | $115 | 2024-03-01 | Buy |
| Cayman Chemical | 12031 | BIM5078 ≥98% | 337506-43-1 | 25mg | $270 | 2024-03-01 | Buy |
1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole Chemical Properties,Uses,Production
Description
HNF4α is a nuclear receptor transcription factor that controls the expression of many genes including those involved in glucose and lipid homeostasis and maintenance of epithelial differentiation. BIM5078 is an HNF4α antagonist that can repress the expression of known HNF4α target genes, inhibiting endogenous insulin expression in T6PNE cells with an IC50 value of 930 nM. BIM5078 binds directly to the ligand binding pocket of HNF4α with an EC50 value of 11.9 nM. However, BIM5078 has unfavorable pharmacokinetic properties including low plasma and microsomal stability (8% remaining after 3 hours and 32% after 1.25 hours, respectively), high binding to plasma proteins (98% bound after 4 hours), and low solubility (0.17 mg/ml after 18 hours). BI6015 is a structural analog of BIM5078 developed for more favorable pharmacokinetics.
1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole Preparation Products And Raw materials
Raw materials
Preparation Products
1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |
| MedBioPharmaceutical Technology Inc | 58 |
| Energy Chemical | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| ApexBio Technology | 58 |