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ChemicalBook >> CAS DataBase List >> 1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole

1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole

1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole price.
  • $62 - $543
  • Product name: 1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole
  • CAS: 337506-43-1
  • MF: C14H10ClN3O4S
  • MW: 351.76
  • EINECS:
  • MDL Number:MFCD01173148
  • Synonyms:1-(2′-Chloro-5′-nitrobenzenesulfonyl)-2-methylbenzimidazole;1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole;BIM5078;BIM5078 Exclusive;1-(2-chloro-5-nitrophenyl)sulfonyl-2-methylbenzimidazole;1H-Benzimidazole, 1-[(2-chloro-5-nitrophenyl)sulfonyl]-2-methyl-;BIM5078 >=98% (HPLC)
Price11 Properties Safety Information Description
11 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Cayman Chemical
  • Sigma-Aldrich
Package
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • ManufacturerAK Scientific
  • Product number5173CE
  • Product description1-(2-Chloro-5-nitrophenyl)sulfonyl-2-methylbenzimidazole
  • Packaging5mg
  • Price$166
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3244
  • Product descriptionBIM5078
  • Packaging5mg
  • Price$68
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3244
  • Product descriptionBIM5078
  • Packaging10mg
  • Price$129
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3244
  • Product descriptionBIM5078
  • Packaging25mg
  • Price$307
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3244
  • Product descriptionBIM5078
  • Packaging50mg
  • Price$543
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number12031
  • Product descriptionBIM5078 ≥98%
  • Packaging5mg
  • Price$62
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number12031
  • Product descriptionBIM5078 ≥98%
  • Packaging10mg
  • Price$115
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number12031
  • Product descriptionBIM5078 ≥98%
  • Packaging25mg
  • Price$270
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number12031
  • Product descriptionBIM5078 ≥98%
  • Packaging50mg
  • Price$477
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0528
  • Product descriptionBIM5078 ≥98% (HPLC)
  • Packaging25mg
  • Price$537
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0528
  • Product descriptionBIM5078 ≥98% (HPLC)
  • Packaging5mg
  • Price$140
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 5173CE 1-(2-Chloro-5-nitrophenyl)sulfonyl-2-methylbenzimidazole 5mg $166 2021-12-16 Buy
ApexBio Technology C3244 BIM5078 5mg $68 2021-12-16 Buy
ApexBio Technology C3244 BIM5078 10mg $129 2021-12-16 Buy
ApexBio Technology C3244 BIM5078 25mg $307 2021-12-16 Buy
ApexBio Technology C3244 BIM5078 50mg $543 2021-12-16 Buy
Cayman Chemical 12031 BIM5078 ≥98% 5mg $62 2024-03-01 Buy
Cayman Chemical 12031 BIM5078 ≥98% 10mg $115 2024-03-01 Buy
Cayman Chemical 12031 BIM5078 ≥98% 25mg $270 2024-03-01 Buy
Cayman Chemical 12031 BIM5078 ≥98% 50mg $477 2024-03-01 Buy
Sigma-Aldrich SML0528 BIM5078 ≥98% (HPLC) 25mg $537 2024-03-01 Buy
Sigma-Aldrich SML0528 BIM5078 ≥98% (HPLC) 5mg $140 2024-03-01 Buy

Properties

Boiling point :573.1±60.0 °C(Predicted)
Density :1.58±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble10mg/mL, clear (warmed)
pka :0.49±0.10(Predicted)
form :powder
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

HNF4α is a nuclear receptor transcription factor that controls the expression of many genes including those involved in glucose and lipid homeostasis and maintenance of epithelial differentiation. BIM5078 is an HNF4α antagonist that can repress the expression of known HNF4α target genes, inhibiting endogenous insulin expression in T6PNE cells with an IC50 value of 930 nM. BIM5078 binds directly to the ligand binding pocket of HNF4α with an EC50 value of 11.9 nM. However, BIM5078 has unfavorable pharmacokinetic properties including low plasma and microsomal stability (8% remaining after 3 hours and 32% after 1.25 hours, respectively), high binding to plasma proteins (98% bound after 4 hours), and low solubility (0.17 mg/ml after 18 hours). BI6015 is a structural analog of BIM5078 developed for more favorable pharmacokinetics.

Suppliers and manufacturers

BOC Sciences ChemeGen(Shanghai) Biotechnology Co.,Ltd. MedBioPharmaceutical Technology Inc Energy Chemical Shanghai Yifei Biotechnology Co. , Ltd. ApexBio Technology