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Methyl 3-amino-4-methylbenzoate

Methyl 3-amino-4-methylbenzoate structure

CAS No.: 18595-18-1

Chemical Name:: Methyl 3-amino-4-methylbenzoate

Synonyms: AKOS BB-3092;3-Amino-p-toluic;Compound Fr13901;Methyl 3-amino-4-met;Nilotinib Impurity 25;LABOTEST-BB LT00848257;Nilotinib EP Impurity B;3-Amino-4-Methylbenzoate;METHYL 3-AMINO-P-TOLUATE;3-amino-2,4-dimethylbenzoate

CBNumber:: CB4316035

Molecular Formula:: C9H11NO2

Molecular Weight:: 165.19

MDL Number:: MFCD00025206

MOL File:: 18595-18-1.mol

MSDS File:: SDS

Last updated:2024-03-28 13:36:31

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Methyl 3-amino-4-methylbenzoate Properties

Melting point	113-117 °C(lit.)
Boiling point	296.3±20.0 °C(Predicted)
Density	1.132±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	3.31±0.10(Predicted)
form	Crystalline Powder
color	White to cream
BRN	2088611
InChIKey	YEPWCJHMSVABPQ-UHFFFAOYSA-N
LogP	1.7 at 22℃ and pH7
CAS DataBase Reference	18595-18-1(CAS DataBase Reference)
FDA UNII	CUK1YN8P3C

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280-P280-P302+P352-P304+P340+P312-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36/37

WGK Germany

Hazard Note

Irritant

HS Code

29224999

NFPA 704

	1
2		0

Methyl 3-amino-4-methylbenzoate price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0002111	Nilotinib impurity B European Pharmacopoeia (EP) Reference Standard	18595-18-1	Y0002111	$186	2023-01-07	Buy
TCI Chemical	A1432	Methyl 3-Amino-4-methylbenzoate >98.0%(GC)	18595-18-1	25g	$27	2024-03-01	Buy
Alfa Aesar	A15348	Methyl 3-amino-4-methylbenzoate, 97%	18595-18-1	5g	$25.65	2024-03-01	Buy
Alfa Aesar	A15348	Methyl 3-amino-4-methylbenzoate, 97%	18595-18-1	25g	$87.65	2024-03-01	Buy
Alfa Aesar	A15348	Methyl 3-amino-4-methylbenzoate, 97%	18595-18-1	100g	$229.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
Y0002111	Y0002111	$186	Buy
A1432	25g	$27	Buy
A15348	5g	$25.65	Buy
A15348	25g	$87.65	Buy
A15348	100g	$229.65	Buy

Methyl 3-amino-4-methylbenzoate Chemical Properties,Uses,Production

Description

Methyl 3-amino-4-methylbenzoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Chemical Properties

Beige powder

Uses

Methyl 3-Amino-4-methylbenzoate is used as a reagent in the synthesis of perfluoroalkylated indoles which are very useful in drug development. It was also used in the preparation of 4-(pyrimidin-2-ylamino) benzamide derivatives which are designed as inhibitors of hedgehog signalling pathway (target of cancer treatment).

Application

Methyl 3-amino-4-methylbenzoate can be used for:
To prepare the methyl 4-methyl-3-((4-(proparg-1-yloxy)benzyl)amino)benzoate, 4-proparg-1-yloxybenzaldehyde (16) and methyl 3-amino-4-methylbenzoate were reacted according to the method IA.
Synthesis of Methyl 4-methyl-3-((4-(2-methylthiazol-4-yl)benzoyl)amino)benzoate
Synthesis of 4-Methyl-3-((4-(2-methylthiazol-4-yl)benzoyl)amino)benzamide

Synthesis of methyl 3-(4-hydroxy-6-methyl-2-oxopyridin-1 (2H)-yl)-4-methylbenzoate
Synthesis of (5-Carbomethoxy-2-methylphenyl)(4-hydroxypheny)diazene: To a solution of 6N HC1 (6 mL) was added methyl 3-amino-4-methylbenzoate (1.62 g, 10.0 mmol). The solution was cooled in an ice-bath, and was diazotized by adding sodium nitrite (0.9 g, 12.0 mmol). To a cold solution of phenol in 21% aqueous NaOH solution (6 mL) was added diazotized solution slowly. After 20 min, the solution was acidfied by adding 4 N aqueous HC1 and was poured into the cold water, filtered, and washed with water. Recrystallization from ethanol gave the product (2.0 g, 74%) as red crystals, mp 181.3-182.2 °C.

Preparation

Synthesis of Methyl 3-amino-4-methylbenzoate: Nitro ester Methyl 4-methyl-3-nitrobenzoate (80 g, 0.410 mol) was subjected to hydrogenation in a Parr shaker in MeOH using Raney Ni as the catalyst (5 g, 20 mol %) at 50 psi for 8 hours. The catalyst was filtered off, washed thoroughly with MeOH and the combined filtrates concentrated under reduced pressure to furnish a yellow solid (65.0 g). Yield : 96% Mp : 114-5°C (lit.14 Mp 116°C)

Definition

ChEBI: Methyl 3-amino-4-methylbenzoate is a benzoate ester.

Methyl 3-amino-4-methylbenzoate synthesis

Synthesis of Methyl 3-amino-4-methylbenzoate from Methanol and 3-Amino-4-methylbenzoic acid

Methyl 3-amino-4-methylbenzoate Preparation Products And Raw materials

Raw materials

3-Amino-4-methylbenzoic acid Methyl 3-bromo-4-methylbenzoate Methanol 4-Methyl-3-nitrobenzoic acid 4-Methyl-3-nitrobenzoic acid methyl ester

Methyl 4-methylbenzoate

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Preparation Products

3-Acetamido-4-methylbenzoic acid Methyl 1H-indazole-6-carboxylate 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Methyl 3-cyano-4-Methylbenzoate 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid methyl ester

5-aMino-2-broMo-4-Methylbenzoic acid Methyl ester 1H-Indazole-6-carboxylic acid, 5-broMo-, Methyl ester

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Methyl 3-amino-4-methylbenzoate Suppliers

Global( 397)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Yangzhou Qinyuan Pharmatech Co.,ltd	+86-18752526868	jennysun@yzqyyykj.com	China	81	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18774	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29881	58
HaBo Hong Kong Co., Limited.	+86-25-18512596065	info@habotech.com	CHINA	933	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1319	58

Supplier	Advantage
Yangzhou Qinyuan Pharmatech Co.,ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
HaBo Hong Kong Co., Limited.	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
Shanghai Yingrui Biopharma Co.,Ltd	58

View Lastest Price from Methyl 3-amino-4-methylbenzoate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-29	Methyl 3-amino-4-methylbenzoate 18595-18-1	US $106.05 / Kg/Drum	25Kg/Drum	99.00%HPLC	8tons/month	Asia Chem I and E (Jiangsu) Co Ltd
2024-11-29	Methyl 3-amino-4-methylbenzoate 18595-18-1	US $0.00 / Kg/Drum	1KG	98%min	10 tons	WUHAN FORTUNA CHEMICAL CO., LTD
2024-10-31	Methyl 3-amino-4-methylbenzoate 18595-18-1	US $0.00 / g	10g	98%	10tons	Yangzhou Qinyuan Pharmatech Co.,ltd

Methyl 3-amino-4-methylbenzoate
18595-18-1
US $106.05 / Kg/Drum
99.00%HPLC
Asia Chem I and E (Jiangsu) Co Ltd

Methyl 3-amino-4-methylbenzoate
18595-18-1
US $0.00 / Kg/Drum
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Methyl 3-amino-4-methylbenzoate
18595-18-1
US $0.00 / g
98%
Yangzhou Qinyuan Pharmatech Co.,ltd

Methyl 3-amino-4-methylbenzoate Spectrum

Methyl 3-amino-4-methylbenzoate(18595-18-1)MS Methyl 3-amino-4-methylbenzoate(18595-18-1)¹HNMR Methyl 3-amino-4-methylbenzoate(18595-18-1)¹³CNMR Methyl 3-amino-4-methylbenzoate(18595-18-1)IR1 Methyl 3-amino-4-methylbenzoate(18595-18-1)IR2

18595-18-1(Methyl 3-amino-4-methylbenzoate)Related Search:

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4-Aminobenzoic acid METSULFURON METHYL Thiophanate-methyl Methyl acrylate 3-Amino-4-methylbenzoic acid

4-Methyl-3-nitrobenzoic acid Methyl METHYL 2-AMINO-3-METHYLBENZOATE

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METHYL 3-AMINO-4-METHYLBENZOATE METHYL 3-AMINO-P-TOLUATE LABOTEST-BB LT00848257 3-Amino-p-Toluic Acid Methyl Ester 3-Amino-4-Methyl Benzoic Acid Methyl Ester 3-Amino-4-Methylbenzoate 3-Amino-p-toluic Methyl 3-amino-4-methylbenzoate 98% Methyl 3-Amion-4-Methylbenzoate AKOS BB-3092 3-AMINO-4-METHYLBENZOIC ACID METHYL ESTER 3-AMINO-P-TOLUIC ACID METHYL ESTER Methyl4-Methyl-3-Aminobenzoate Methyl 3-amino-4-met 3-Amino-4-methylbenzoic Acid Methyl Ester Methyl 3-Amino-p-toluate 3-Amino-p-toluic Acid Methyl Ester Methyle3-amino-4-methylbenzoate 5-(Methoxycarbonyl)-2-methylaniline, 2-Amino-4-(methoxycarbonyl)toluene, 5-(Methoxycarbonyl)-o-toluidine Benzoic acid, 3-aMino-4-Methyl-, Methyl ester Methyl-3-amino-4-methylbenozate 3-amino-2,4-dimethylbenzoate Nilotinib Impurity 25 Nilotinib EP Impurity B Methyl 3-Amino-4-methylbenzoate > Methyl 3-amino-4-methylbenzoate 18595-18-1 Nilotinib USP Related Compound B Benzoic acid, 3-amino-4-methyl-, methyl ester (9CI, ACI) 3-amino-4-methyl-Benzoic acid methyl ester (9CI ACI) Compound Fr13901 Nilotinib Hydrochloride Monohydrate EP Impurity B Nilotinib Impurity 17(Nilotinib EP Impurity B) 18595-18-1 18585-18-1 Esters Organic Building Blocks Building Blocks Carbonyl Compounds C8 to C9 Building Blocks C8 to C9 Carbonyl Compounds Chemical Synthesis Organic Building Blocks Aromatic Esters Esters Phenyls & Phenyl-Het FINE Chemical & INTERMEDIATES Acids and Derivatives Amines and Anilines bc0001