2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid
- CAS No.
- 32675-71-1
- Chemical Name:
- 2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid
- Synonyms
- (Rac)-RG108;2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid;DNA Methyltransferase Inhibitor - CAS 32675-71-1 - Calbiochem;1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-
- CBNumber:
- CB43372267
- Molecular Formula:
- C19H14N2O4
- Molecular Weight:
- 334.33
- MDL Number:
- MOL File:
- 32675-71-1.mol
Last updated:2023-07-02 08:28:07
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid price More Price(1)
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid Chemical Properties,Uses,Production
General Description
A cell-permeable, specific DNA methyltransferases inhibitor (IC50 = 115 nM for CpG methylase M.SssI) that displays anti-proliferative, but not cytotoxic, properties. Unlike the commonly used inhibitor 5-azacytidine, RG108 directly interacts with DNA methyltransferase active site via its carboxy group.
Biochem/physiol Actions
Cell permeable: yes
![85-44-9](/CAS/GIF/85-44-9.gif)
![54-12-6](/CAS/GIF/54-12-6.gif)
![32675-71-1](/CAS/20180529/GIF/32675-71-1.gif)
Synthesis of 2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid from Phthalic anhydride and DL-Tryptophan
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid Suppliers
Global( 11)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 18021 | 56 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Zhengzhou Ruike Biochemical Technology Co., Ltd. | 18521304688 | 421551521@qq.com | China | 214 | 58 |
Changzhou Xianglong Pharmaceutical Technology Co., LTD | 0519-88910898; 18661161657 | yaoxiangqiu2021@163.com | China | 9997 | 58 |
Yantai Sheng Kai Lun Biological Products Co. , Ltd. | 3119594100 | mark@sklnchem.cn | China | 7792 | 58 |
Tan-Mo Technology Co., Ltd. | 19850211281 | qiann@gbw-china.com | China | 1980 | 58 |
Nantong Hanfang Biotechnology Co. , Ltd. | 18616537568 | hanfangpharma@126.com | China | 30968 | 58 |
2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid
DNA Methyltransferase Inhibitor - CAS 32675-71-1 - Calbiochem
1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-
(Rac)-RG108
32675-71-1