2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid

2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid 구조식 이미지
카스 번호:
32675-71-1
상품명:
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid
동의어(영문):
(Rac)-RG108;2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid;DNA Methyltransferase Inhibitor - CAS 32675-71-1 - Calbiochem;1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-
CBNumber:
CB43372267
분자식:
C19H14N2O4
포뮬러 무게:
334.33
MOL 파일:
32675-71-1.mol
MSDS 파일:
SDS

2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid 속성

끓는 점
606.0±50.0 °C(Predicted)
밀도
1.502±0.06 g/cm3(Predicted)
저장 조건
+2C to +8C
물리적 상태
노란색 고체
산도 계수 (pKa)
3.62±0.10(Predicted)

안전

2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid C화학적 특성, 용도, 생산

일반 설명

A cell-permeable, specific DNA methyltransferases inhibitor (IC50 = 115 nM for CpG methylase M.SssI) that displays anti-proliferative, but not cytotoxic, properties. Unlike the commonly used inhibitor 5-azacytidine, RG108 directly interacts with DNA methyltransferase active site via its carboxy group.

Biochem/physiol Actions

Cell permeable: yes

2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid 준비 용품 및 원자재

원자재

준비 용품


2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid 공급 업체

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