Biotinylated isoxazole 95%
- CAS No.
- 1377605-22-5
- Chemical Name:
- Biotinylated isoxazole 95%
- Synonyms
- Biotin isoxazole;Biotinylated isoxazole;Biotinylated isoxazole 95%;1H-Thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-, 6-[[[5-(2-thienyl)-3-isoxazolyl]carbonyl]amino]hexyl ester, (3aS,4S,6aR)-
- CBNumber:
- CB43384552
- Molecular Formula:
- C24H32N4O5S2
- Molecular Weight:
- 520.66
- MDL Number:
- MOL File:
- 1377605-22-5.mol
| Boiling point | 800.4±65.0 °C(Predicted) |
|---|---|
| Density | 1.251±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (30 mg/ml with warming) |
| form | powder or crystals |
| pka | 13.77±0.46(Predicted) |
| color | Beige |
| Stability | Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
Biotinylated isoxazole 95% price More Price(2)
Biotinylated isoxazole 95% Chemical Properties,Uses,Production
Description
Biotin-isoxazole (1377605-22-5) precipitates hundreds of RNA-binding proteins with significant overlap to the constituents of RNA granules.1,2 In one study roughly 580 nuclear proteins were identified as being precipitated by B-Isox including TAF15, RNA polymerase II (largest subunit), numerous subunits of the mediator complex as well as a variety of enzymes involved in epigenetic modification of histones.3? SR domains were found to be the determinant that facilitates B-Isox precipitation.4 Also allows for the fractionation / isolation of SG-associated proteins and RNA precipitates.5
Uses
When exposed to cells or tissue lysates, biotinylated isoxazole (b-isox) was shown to precipitate RNA-binding proteins with significant overlap to the components of RNA granules. By reversibly aggregating and disaggregating structures similar to RNA granules, b-isox has lent insight to polypeptides necessary for the reversible aggregation of RNA-binding proteins.
This product was previously listed as T511617.
References
Kato et al. (2012), Cell-free formation of rNA granules: low complexity sequence domains form dynamic fibers within hydrogels; Cell, 149 753 Han et al. (2012), Cell-free formation of RNA granules: bound RNAs identify features and components of cellular assemblies; Cell, 149 768 Kwon et al. (2013), Phosphorylation-regulated binding of RNA polymerase II to fibrous polymers of low-complexity domains; Cell, 155 1049 Kwon et al. (2014), Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells; Science, 345 1139 Panas et al. (2015), Methods for the characterization of stress granules in virus infected cells; Methods, 90 57
Biotinylated isoxazole 95% Preparation Products And Raw materials
Raw materials
Preparation Products
Biotinylated isoxazole 95% Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2991 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 13675144456 | sean.lv@synzest.com | China | 11442 | 58 |
| Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 15162312715 | sales@szzxbio.com | China | 2994 | 58 |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | +86-18521732826 | market@aladdin-e.com | China | 48465 | 58 |
| Henan Shengxiang Pharmatech LTD | 15515658315 | 3777161761@qq.com | China | 329 | 58 |