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ChemicalBook >> CAS DataBase List >>3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one

3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one

3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one Structure
3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one structure
CAS No.
714240-31-0
Chemical Name:
3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one
Synonyms
NCGC00029283;NCGC00029283,NCGC-00029283;NCGC00029283, 10 mM in DMSO;3-(5-(4-Fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2-ol;3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one;2(1H)-Quinolinone, 3-[5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl]-6-methoxy-
CBNumber:
CB44083407
Molecular Formula:
C18H12FN3O3
Molecular Weight:
337.3
MDL Number:
MFCD05729526
MOL File:
714240-31-0.mol
Last updated:2024-11-19 15:53:33
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3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one Properties

Density 1.365±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
pka 9.37±0.70(Predicted)
form Solid
color White to yellow

3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one Chemical Properties,Uses,Production

Biological Activity

NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively[1]. NCGC00029283 (0-100 μM; 24-72 h) effectively blocks cell proliferation in U2-OS cells[1].

References

[1]. Joshua A Sommers, et al. A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN). PLoS One. 2019 Jan 9;14(1):e0210525.

3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one Suppliers

Global( 24)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32965 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998 757984502@qq.com China 892 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203 info@chemextension.com China 42056 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52924 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9805 58
Shanghai SuperLan Chemcial Technique Centre 021-2022843681 15618226720 lucy@atkchemical.com China 9987 58
Chuzhou KeMail Chemical Technology Co., Ltd 0550-5196001 15000891977 wj520wjxby@126.com China 1925 55
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 +86-13028896684; sales@rrkchem.com China 57423 58
ShangHai ChuanQian Chemcial Technique Centre 15869524721 3525679403@qq.com China 4342 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
Aladdin Scientific 		58
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai SuperLan Chemcial Technique Centre 58
Chuzhou KeMail Chemical Technology Co., Ltd 55
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58
ShangHai ChuanQian Chemcial Technique Centre 58

View Lastest Price from 3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
NCGC00029283 pictures 2024-11-19 NCGC00029283
714240-31-0
 US $113.00-455.00 / mg 99.6% 10g TargetMol Chemicals Inc.
  • NCGC00029283 pictures
  • NCGC00029283
    714240-31-0
  • US $113.00-455.00 / mg
  • 99.6%
  • TargetMol Chemicals Inc.

3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one Spectrum

3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one(714240-31-0)1HNMR
3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one NCGC00029283 NCGC00029283,NCGC-00029283 2(1H)-Quinolinone, 3-[5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl]-6-methoxy- 3-(5-(4-Fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2-ol NCGC00029283, 10 mM in DMSO 714240-31-0