2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BENZIMIDAZOLE
![2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BENZIMIDAZOLE Structure](StructureFile/ChemBookStructure3/GIF/CB4417228.gif)
- CAS No.
- 312749-73-8
- Chemical Name:
- 2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BENZIMIDAZOLE
- Synonyms
- CLP-3094;EU-0033941;ZINC02074828;BAS 00450541;AH-034/34344061;2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE;2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BENZIMIDAZOLE;2-[2-(4-chlorophenoxy)ethylsulfanyl]-1H-benzimidazole;1H-Benzimidazole, 2-[[2-(4-chlorophenoxy)ethyl]thio]-;2-((2-(4-Chlorophenoxy)ethyl)thio)-1H-benzo[d]imidazole
- CBNumber:
- CB4417228
- Molecular Formula:
- C15H13ClN2OS
- Molecular Weight:
- 304.79
- MDL Number:
- MFCD00805733
- MOL File:
- Mol file
2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BENZIMIDAZOLE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 066588 | 2-{[2-(4-Chlorophenoxy)ethyl]thio}-1H-benzimidazole | 312749-73-8 | 500mg | $119 | 2021-12-16 | Buy |
| Crysdot | CD11147489 | 2-((2-(4-Chlorophenoxy)ethyl)thio)-1H-benzo[d]imidazole 97% | 312749-73-8 | 1g | $872 | 2021-12-16 | Buy |
2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BENZIMIDAZOLE Chemical Properties,Uses,Production
Description
GPR142 is highly expressed in the pancreas and immune system and shares 33% homology with GPR139.1 Endogenous agonists identified to date include aromatic amino acids such as tryptophan and phenylalanine.2?CLP-3094? (312749-73-8) was identified as a potent and selective GPR142 antagonist with an IC50=2.3 μM against 1 mM L-tryptophan. It inhibited insulin secretion from islets induced by L-tryptophan and other agonists and displayed anti-inflammatory activity in a mouse arthritis model.3
References
Susens et al. (2006), Characterisation and differential expression of two very closely related G-protein-coupled receptors, GPR139 and GPR142, in mouse tissue and during mouse development, Neuropharmacology, 55 512 Lizarzaburu et al. (2012), Discovery and optimization of a novel series of GPR142 agonists for the treatment of type 2 diabetes mellitus; Bioorg. Med. Chem. Lett., 22 5942 Murakoshi et al. (2017), Discovery and pharmacological effects of a novel GPR142 antagonist; Recept. Signal. Transduct. Res., 37 290
2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BENZIMIDAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BENZIMIDAZOLE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3770 | 55 |
| Yujinpharma(Tianjin) Technology Co.,Ltd. | 13370351217 kungfu1217@1 | kungfu1217@163.com | China | 9316 | 58 |
| Henan Weituxi Chemical Technology Co., Ltd. | 0371-63284658 18135795563 | 2885349392@qq.com | China | 9990 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |
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| Nanjing Shizhou Biology Technology Co.,Ltd | -- | purchase@synzest.com | China | 6857 | 58 |
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