4',6'-DIMETHOXY-2'-HYDROXYCHALCONE
- CAS No.
- 1775-97-9
- Chemical Name:
- 4',6'-DIMETHOXY-2'-HYDROXYCHALCONE
- Synonyms
- FlavoringB;Flavokavin B;FLAVOKAWIN B;FLAVOKAWAIN B;Flavokavain B;FLAVOKAVAIN B(P);Flavokawain B-RM;CARDAMONIN-4'-METHYL ETHER;4',6'-DIMETHOXY-2'-HYDROXYCHALCONE;2'-Hydroxy-4',6'-Dimethoxychalcone
- CBNumber:
- CB4430922
- Molecular Formula:
- C17H16O4
- Molecular Weight:
- 284.31
- MDL Number:
- MFCD00075877
- MOL File:
- 1775-97-9.mol
- MSDS File:
- SDS
| Melting point | 85-87°C |
|---|---|
| Boiling point | 500.1±50.0 °C(Predicted) |
| Density | 1.203±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 6.84±0.40(Predicted) |
| form | Solid |
| color | Yellow to Dark Yellow |
| LogP | 4.206 (est) |
| CAS DataBase Reference | 1775-97-9(CAS DataBase Reference) |
| FDA UNII | R9WC6SM4UQ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
4',6'-DIMETHOXY-2'-HYDROXYCHALCONE price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19652 | Flavokawain B ≥98% | 1775-97-9 | 500μg | $34 | 2024-03-01 | Buy |
| Cayman Chemical | 19652 | Flavokawain B ≥98% | 1775-97-9 | 1mg | $65 | 2024-03-01 | Buy |
| Cayman Chemical | 19652 | Flavokawain B ≥98% | 1775-97-9 | 5mg | $253 | 2024-03-01 | Buy |
| Cayman Chemical | 19652 | Flavokawain B ≥98% | 1775-97-9 | 10mg | $404 | 2024-03-01 | Buy |
| Usbiological | 300275 | Flavokawain B | 1775-97-9 | 20mg | $552 | 2021-12-16 | Buy |
4',6'-DIMETHOXY-2'-HYDROXYCHALCONE Chemical Properties,Uses,Production
Description
Flavokawain B is a natural chalcone first isolated from extracts of kava roots. It induces apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50s = 32, 48, 6.2, and 3.9 μM for LAPC4, LNCaP, PC-3, and DU145 cells, respectively, treated for 48 hours), with increased expression of the proapoptotic protein Bim. Flavokawain B increases Bim expression and inhibits growth of DU145 xenografts in mice. It also increases Bim expression, promotes apoptosis, and induces cell cycle arrest in uterine leiomyosarcoma cells. However, flavokawain B is hepatotoxic, triggering oxidative stress, inhibiting NF-κB signaling, and activating MAPK pathways, culminating in HepG2 and L-02 cell death (LD50s = 15 and 32 μM, respectively).
Uses
Flavokavain B is a secondary metabolite of the kava plant (Piper methysticum Forst. f., Piperaceae, which has anticancer properties and demonstrated oral efficacy in murine cancer models. ?Futhermore, it also has suspected roles in rare cases of kava-induced hepatotoxicity. In addition, it is a potential candidate for the development of novel antifungal phytotherapic products.
Definition
ChEBI: Flavokawain B is a member of the class of chalcones that consists of trans-chalcone substituted by hydroxy group at positions 2' and methoxy groups at positions 4' and 6'. Isolated from Piper methysticum and Piper rusbyi, it exhibits antileishmanial, anti-inflammatory and antineoplastic activities. It has a role as a metabolite, an antileishmanial agent, an anti-inflammatory agent, an apoptosis inducer and an antineoplastic agent. It is a member of chalcones, a dimethoxybenzene and a member of phenols. It is functionally related to a trans-chalcone.
4',6'-DIMETHOXY-2'-HYDROXYCHALCONE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29811 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10319 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
View Lastest Price from 4',6'-DIMETHOXY-2'-HYDROXYCHALCONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-02-24 | Flavokawain B
1775-97-9
|
US $0.00 / mg | 20mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2020-01-19 | 4',6'-DIMETHOXY-2'-HYDROXYCHALCONE
1775-97-9
|
US $3.00 / KG | 1KG | 99% | 1kg,5kg,50kg | Career Henan Chemical Co |
-
- Flavokawain B
1775-97-9
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- 4',6'-DIMETHOXY-2'-HYDROXYCHALCONE
1775-97-9
- US $3.00 / KG
- 99%
- Career Henan Chemical Co
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