4',6'-DIMETHOXY-2'-HYDROXYCHALCONE
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4',6'-DIMETHOXY-2'-HYDROXYCHALCONE 속성
- 녹는점
- 85-87°C
- 끓는 점
- 500.1±50.0 °C(Predicted)
- 밀도
- 1.203±0.06 g/cm3(Predicted)
- 저장 조건
- -20°C Freezer
- 용해도
- 클로로포름(약간 용해됨), 메탄올(약간 용해됨)
- 산도 계수 (pKa)
- 6.84±0.40(Predicted)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 노란색에서 진한 노란색까지
- LogP
- 4.206 (est)
- CAS 데이터베이스
- 1775-97-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
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| 신호 어: | Warning | |||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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4',6'-DIMETHOXY-2'-HYDROXYCHALCONE C화학적 특성, 용도, 생산
개요
Flavokawain B is a natural chalcone first isolated from extracts of kava roots. It induces apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50s = 32, 48, 6.2, and 3.9 μM for LAPC4, LNCaP, PC-3, and DU145 cells, respectively, treated for 48 hours), with increased expression of the proapoptotic protein Bim. Flavokawain B increases Bim expression and inhibits growth of DU145 xenografts in mice. It also increases Bim expression, promotes apoptosis, and induces cell cycle arrest in uterine leiomyosarcoma cells. However, flavokawain B is hepatotoxic, triggering oxidative stress, inhibiting NF-κB signaling, and activating MAPK pathways, culminating in HepG2 and L-02 cell death (LD50s = 15 and 32 μM, respectively).용도
Flavokavain B is a secondary metabolite of the kava plant (Piper methysticum Forst. f., Piperaceae, which has anticancer properties and demonstrated oral efficacy in murine cancer models. ?Futhermore, it also has suspected roles in rare cases of kava-induced hepatotoxicity. In addition, it is a potential candidate for the development of novel antifungal phytotherapic products.4',6'-DIMETHOXY-2'-HYDROXYCHALCONE 준비 용품 및 원자재
원자재
준비 용품
4',6'-DIMETHOXY-2'-HYDROXYCHALCONE 공급 업체
글로벌( 139)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 |
scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 |
sales@biopurify.com | China | 3772 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 |
sales@pioneerbiotech.com | China | 3000 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 |
ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29815 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 |
sales@chemnorm.com | CHINA | 2935 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 |
ada@ipurechemical.com | China | 10319 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6312 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | China | 52849 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 |
dj@sgtlifesciences.com | China | 12373 | 58 |
4',6'-DIMETHOXY-2'-HYDROXYCHALCONE 관련 검색:
탄게레틴 2'-히드록시-4,4',6'-트리메톡시칼콘 2-히드록시캘콘 시넨세틴
EUPATORIN-5-METHYL ETHER
3'-BENZYLOXY-4',5,6,7-TETRAMETHOXYFLAVONE
3',4',5,7-TETRAMETHOXYFLAVONE
3',4',5',5,6,7-HEXAMETHOXYFLAVONE
SCUTELLAREIN TETRAMETHYL ETHER
Hesperidin methylchalcone
5,7-DIMETHOXYFLAVONE
3',4',5',5,7-PENTAMETHOXYFLAVONE
5,6,7-TRIMETHOXYFLAVONE
2',4-DIHYDROXY-4',6'-DIMETHOXYCHALCONE
DIMETHOXY-2'-HYDROXYCHALCONE, 2,3-,2,3-DIMETHOXY-2'-HYDROXYCHALCONE
2-Hydroxychalcone
2'-Hydroxychalcone
CARDAMONIN