ChemicalBook >> CAS DataBase List >>Foretinib-Based PROTAC 7

Foretinib-Based PROTAC 7

Foretinib-Based PROTAC 7 structure

CAS No.: 2230821-68-6

Chemical Name:: Foretinib-Based PROTAC 7

Synonyms: Foretinib-Based PROTAC 7;1-N'-[3-fluoro-4-[7-[3-[3-[3-[[(2R)-1-[(2R,4S)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-3-oxopropoxy]propoxy]propoxy]-6-methoxyquinolin-4-yl]oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

CBNumber:: CB44667908

Molecular Formula:: C58H65F2N7O11S

Molecular Weight:: 1106.25

MDL Number:

MOL File:: 2230821-68-6.mol

Last updated:2023-06-30 15:45:59

Request For Quotation

Foretinib-Based PROTAC 7 Properties

Boiling point	1226.5±65.0 °C(Predicted)
Density	1.341±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO\|55.31\|50\|
pka	13.14±0.70(Predicted)

Foretinib-Based PROTAC 7 Chemical Properties,Uses,Production

Description

SJF-8240 is a c-MET degrader. It comprises MET inhibitor foretinib joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. SJF-8240 degrades c-MET within 6 hours in vitro and inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation. It also degrades exon-14-deleted c-MET in Hs746T cells.

storage

Store at -20°C

Foretinib-Based PROTAC 7 Preparation Products And Raw materials

Raw materials

Preparation Products

Foretinib-Based PROTAC 7 Suppliers

Global( 9)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai finete Pharmaceutical Co., Ltd.	+86-18221039705		CHINA	139	55
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 18892239720	psaitong@jm-bio.com	China	12308	58
Shanghai finete Pharmaceutical Co., Ltd.	021-021-00000000 18221039705	finetechpharm@126.com	China	183	58
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1365	58
Beijing Biocreative Technology Co., Ltd.	15522676233	3007606172@qq.com	China	1249	58
https://hanhongsci.com/	021-54306202 18917919676	info@hanhongsci.com	China	29990	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.com	China	24246	58
Nanjing Shizhou Biology Technology Co.,Ltd	025-85560043 15850508050	cindy.huang@synzest.com	China	12007	58

Supplier	Advantage
Shanghai finete Pharmaceutical Co., Ltd.	55
Aladdin Scientific	58
Beijing Jin Ming Biotechnology Co., Ltd.	58
Shanghai finete Pharmaceutical Co., Ltd.	58
Jilin Province Woda Biotechnology Co., Ltd.	58
Beijing Biocreative Technology Co., Ltd.	58
https://hanhongsci.com/	58
TargetMol Chemicals Inc.	58
Nanjing Shizhou Biology Technology Co.,Ltd	58

Foretinib-Based PROTAC 7 1-N'-[3-fluoro-4-[7-[3-[3-[3-[[(2R)-1-[(2R,4S)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-3-oxopropoxy]propoxy]propoxy]-6-methoxyquinolin-4-yl]oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 2230821-68-6 C58H65F2N7O11S