N6-CYCLOHEXYLADENOSINE
- CAS No.
- 36396-99-3
- Chemical Name:
- N6-CYCLOHEXYLADENOSINE
- Synonyms
- CHA;Cyclohexyladenosine;N-Cyclohexyladenosine;N6-CYCLOHEXYLADENOSINE;Adenosine, N-cyclohexyl-;N6-Cyclohexyladenosine,CHA;N(sup 6)-cyclohexyladenosine;(2R,4S)-4-fluoropyrrolidine-6-carboxylicacid;N6-CYCLOHEXYLADENOSINE (CHA) SELECTIVE A 1 ADENOSIN;(2R,3R,4S,5R)-2-(6-(CyclohexylaMino)-9H-purin-9-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol
- CBNumber:
- CB4468462
- Molecular Formula:
- C16H23N5O4
- Molecular Weight:
- 349.38
- MDL Number:
- MFCD00036808
- MOL File:
- 36396-99-3.mol
- MSDS File:
- SDS
Melting point | 182 - 184°C |
---|---|
Boiling point | 675.2±65.0 °C(Predicted) |
Density | 1.71±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly) |
form | Solid |
pka | 13.12±0.70(Predicted) |
color | White to Off-White |
Stability | Hygroscopic |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H332-H335 |
Precautionary statements | P261-P280-P305+P351+P338 |
WGK Germany | 3 |
HS Code | 29349990 |
N6-CYCLOHEXYLADENOSINE price More Price(23)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 28427 | N6-Cyclohexyladenosine | 36396-99-3 | 50mg | $96 | 2024-03-01 | Buy |
Cayman Chemical | 28427 | N6-Cyclohexyladenosine | 36396-99-3 | 100mg | $180 | 2024-03-01 | Buy |
Cayman Chemical | 28427 | N6-Cyclohexyladenosine | 36396-99-3 | 25mg | $62 | 2024-03-01 | Buy |
Tocris | 6863 | N6-Cyclohexyladenosine ≥98%(HPLC) | 36396-99-3 | 50 | $85 | 2021-12-16 | Buy |
TRC | C989785 | N6-Cyclohexyladenosine | 36396-99-3 | 500mg | $745 | 2021-12-16 | Buy |
N6-CYCLOHEXYLADENOSINE Chemical Properties,Uses,Production
Description
N6-Cyclohexyladenosine is an adenosine receptor agonist. It selectively binds to adenosine A1 receptors in rat cortical membranes (IC50 = 2.3 nM) over A2 receptors in rat striatal membranes (IC50 = 870 nM). N6-Cyclohexyladenosine decreases heart rate and increases coronary flow in a perfused working rat heart model ex vivo (EC25s = 5 and 860 nM, respectively). In vivo, it decreases heart rate and blood pressure in normotensive rats (EC25s = 2.4 and 4.2 μg/kg, respectively). N6-Cyclohexyladenosine (100 μM) induces sleep in rats when administered via basal forebrain infusion. N6-Cyclohexyladenosine also decreases locomotor activity in mice (ED50 = 60 μg/kg, i.p.).
Uses
N6-Cyclohexyladenosine is a derivative of Adenosine (A280400), and is used testing adenosine A1 and A2A receptor activation for pharmaceuticals such as antidepressants. N6-Cyclohexyladenosine also is used as a JAK2 inhibitor, blocking STAT3 signalling in human cancer cells.
Biochem/physiol Actions
Selective A1 adenosine receptor agonist.
storage
Store at -20°C
N6-CYCLOHEXYLADENOSINE Preparation Products And Raw materials
N6-CYCLOHEXYLADENOSINE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
Nanjing Baifuli Technology Co., Ltd. | +86-15335185688 | sales@unisyn.cn | CHINA | 332 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 9980 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
Nanjing Chemlin Chemical Co., Ltd | 025-83697070 | info@chemlin.com.cn | China | 18082 | 64 |
Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10269 | 58 |
Chengdu NoVi Biotechnology Co., Ltd. | 028-81458053 | novibiotech@163.com sales@novi-biotech.com | China | 226 | 55 |
Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
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