BETAMETHASONE BENZOATE (200 MG)
- CAS No.
- 22298-29-9
- Chemical Name:
- BETAMETHASONE BENZOATE (200 MG)
- Synonyms
- W-5975;17-Benzoate;16-beta)-(11-beta;betamethasonebenzoate;Nintedanib Impurity 155;betamethasone17-benzoate;BETAMETHASONE BENZOATE (200 MG);Betamethasone Benzoate (1067307);BETAMETHASONE BENZOATE USP(CRM STANDARD);9-fluoro-11,21-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl benzoate
- CBNumber:
- CB4501383
- Molecular Formula:
- C35H41FO8
- Molecular Weight:
- 608.6936432
- MDL Number:
- MFCD00867437
- MOL File:
- 22298-29-9.mol
| Melting point | 225-228° |
|---|---|
| alpha | D24 +63.5° (dioxane) |
| Boiling point | 641.0±55.0 °C(Predicted) |
| Density | 1.1732 (estimate) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 12.93±0.70(Predicted) |
| FDA UNII | 877K0XW47A |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360FD-H373 |
| Precautionary statements | P202-P260-P280-P308+P313-P405-P501 |
| RIDADR | UN 2811 6.1 / PGII |
| WGK Germany | 1 |
| HS Code | 2937220000 |
| Toxicity | LD50 scu-rat: 194 mg/kg TXAPA9 8,250,66 |
BETAMETHASONE BENZOATE (200 MG) price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 1067307 | Betamethasone benzoate | 22298-29-9 | 200mg | $460 | 2024-03-01 | Buy |
| TRC | B327995 | Betamethasone17-Benzoate | 22298-29-9 | 50mg | $140 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0001695 | BETAMETHASONE BENZOATE 95.00% | 22298-29-9 | 5MG | $497.72 | 2021-12-16 | Buy |
BETAMETHASONE BENZOATE (200 MG) Chemical Properties,Uses,Production
Originator
Benisone,Warner Lambert,US,1973
Uses
BETAMETHASONE BENZOATE (200 MG) is an analog of Betamethasone (B327000), a glucocorticoid used as an anti-inflammatory agent.
Definition
ChEBI: Betamethasone benzoate is a 21-hydroxy steroid.
Manufacturing Process
A mixture of 50 g of betamethasone, 50 cc of dimethylformamide, 50 cc of methyl orthobenzoate and 1.5 g of p-toluenesulfonic acid is heated for 24 hours on oil bath at 105°C while a slow stream of nitrogen is passed through the mixture and the methanol produced as a byproduct of the reaction is distilled off. After addition of 2 cc of pyridine to neutralize the acid catalyst the solvent and the excess of methyl orthobenzoate are almost completely eliminated under vacuum at moderate temperature. The residue is chromatographed on a column of 1,500 g of neutral aluminum oxide. By elution with ether-petroleum ether 30 g of a crystalline mixture are obtained consisting of the epimeric mixture of 17α,21-methyl orthobenzoates. This mixture is dissolved without further purification, in 600 cc of methanol and 240 cc of methanol and 240 cc of aqueous 2N oxalic acid are added to the solution. The reaction mixture is heated at 40°-50°C on water bath, then concentrated under vacuum, The residue, crystallized from acetone-ether, gives betamethasone 17-benzoate, MP 225°-231°C.
brand name
Uticort (Parke- Davis).
Therapeutic Function
Glucocorticoid
Safety Profile
Poison by subcutaneous route.An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits toxic fumes of F-.
BETAMETHASONE BENZOATE (200 MG) Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32222 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9815 | 79 |
| ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 18146 | 56 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 | 3193328036@qq.com | China | 18338 | 68 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 +86-13028896684; | sales@rrkchem.com | China | 57422 | 58 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 028-81700200 18108052721 | 2850505130@qq.com | China | 5173 | 58 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988968278 | YN_research@163.com | China | 2892 | 58 |