HALOPROGIN
- CAS No.
- 777-11-7
- Chemical Name:
- HALOPROGIN
- Synonyms
- polik;m1028;halotex;mycilan;mycanden;Fungaclor;haloprogin;NSC-100071;Haloproginum;HALOPROGIN (200 MG)
- CBNumber:
- CB4501419
- Molecular Formula:
- C9H4Cl3IO
- Molecular Weight:
- 361.39
- MDL Number:
- MFCD00056358
- MOL File:
- 777-11-7.mol
- MSDS File:
- SDS
| Melting point | 113-114° |
|---|---|
| Boiling point | 477.49°C (rough estimate) |
| Density | 1.9350 (estimate) |
| form | Solid |
| color | White to off-white |
| FDA UNII | AIU7053OWL |
| ATC code | D01AE11 |
SAFETY
Risk and Safety Statements
| Hazard Codes | Xn |
|---|---|
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36 |
| RTECS | KO1225000 |
| Toxicity | LD50 in mice: >3 g/kg orally and s.c.; 510 mg/kg i.p. (Seki, 1963) |
HALOPROGIN Chemical Properties,Uses,Production
Originator
Halotex,Westwood,US,1972
Uses
Haloprogin is a topical antifungal agent used in the treatment of dermatophytic and monilial infections.
Uses
Antibacterial.
Definition
ChEBI: Haloprogin is an aromatic ether.
Indications
Haloprogin is used as an external drug for moderate dermatophyte infections (shingles), and it is effective for superficial candida infections. Synonyms of this drug are halotex, mycilan, micanden, and others.
Manufacturing Process
4.7 grams of 2,4,5-trichlorophenyl propargyl ether (MP 64° to 65°C) are added to an aqueous solution of cupro-ammonium complex salt which has been prepared by warming a mixture of 4.0 grams of cuprous chloride, 11.0 grams of ammonium carbonate and 20 cc of water to 50°C. The resulting admixture is shaken vigorously. The cuprous acetylide deposited is filtered, washed with water and suspended in 100 cc of water, and the suspension is mixed under agitation with a solution of 5.0 grams of iodine and 5.0 grams of potassium iodide in 15 cc of water. The mixture is stirred for a period of 1 hour. The precipitate is filtered, washed with water and extracted with ether. After the drying of the ethereal extract, the solvent is distilled off. Recrystallization of the residue from n-hexane gives about 5.6 grams of 2,4,5- trichlorophenyi iodopropargyl ether, MP 114° to 115°C.
brand name
Halotex (Westwood-Squibb).
Therapeutic Function
Antibacterial
General Description
3-Iodo-2-propynyl-2,4,5-trichlorophenyl ether (Halotex)crystallizes as white to pale yellow forms that are sparinglysoluble in water and very soluble in ethanol. It is an etherealderivative of a phenol. Haloprogin is used as a 1% cream forthe treatment of superficial tinea infections.
Formulations of haloprogin should be protected fromlight because the compound is photosensitive. Haloprogin isavailable as a solution and a cream, both in a 1% concentration.Haloprogin is probably not the first topical agent thatshould be recommended. Although the cure rates for topicalfungal infections are relatively high, they come at a highprice. The lesion typically worsens before it improves.Inflammation and painful irritation are common.
Synthesis
Haloprogin, 3-iodo-2-propinyl-2,4,5-trichlorophenyl ether (35.4.11), is synthesized by an iodide substitution using a mixture of iodine and potassium iodide and a cupric derivative of 2,4,5-trichlorophenylpropargyl ether (35.4.10), which is synthesized by a standard method from propargyl bromide and 2,4,5-trichlorophenol in the presence of sodium hydroxide.
HALOPROGIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22854 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19881 | 58 |
| Shanghai Changyan Chem & Tech Co., Ltd. | 021-20242659 18930833303 | Sales@changyanchem.cn | China | 5010 | 55 |
| Shanghai alkynechem Co., Ltd. | 086-021-15821262312 15821262312 | info@alkynechem.com | China | 1985 | 58 |
| Hebei Zhenjia new material Co., LTD | 0319-5925599 13315915972 | 13313090628@163.com | China | 2916 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 62072 | 58 |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 029-029-81148696 18161915376 | 1040@dideu.com | China | 9799 | 58 |
Related articles
- Mechanism and Toxicity of Haloprogin
- Haloprogin (3-iodo-2-propynyl 2,4,5-trichlorophenyl ether; Halotex cream) has been used as a topical agent for the treatment o....
- Mar 31，2022
View Lastest Price from HALOPROGIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-28 | Haloprogin
777-11-7
|
US $1520.00-2500.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2021-07-20 | HALOPROGIN (200 MG) USP/EP/BP
777-11-7
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
-
- Haloprogin
777-11-7
- US $1520.00-2500.00 / mg
- TargetMol Chemicals Inc.
-
- HALOPROGIN (200 MG) USP/EP/BP
777-11-7
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited