CLOZAPINE N-OXIDE
- CAS No.
- 34233-69-7
- Chemical Name:
- CLOZAPINE N-OXIDE
- Synonyms
- CLOZAPINE N-OXIDE;Clozapine Impurity 16;Clozapine N-Oxide imp;Clozapine N-oxide (CNO);Clozapine N-oxide solution;Clozapine N-oxide Methanol Adduct;Clozapine N-oxide dihydrochloride NEW;Clozapine N-oxide (4-oxido-piprazinyl);Clozapine N-Oxide (1.0 mg/mL in Methanol);MAJORMETABOLITEOFCLOZAPINE.POSSESSESLITTLEORNOACTIVITYAT5-HTRECEPTORS
- CBNumber:
- CB4759216
- Molecular Formula:
- C18H19ClN4O
- Molecular Weight:
- 342.82
- MDL Number:
- MFCD00210190
- MOL File:
- 34233-69-7.mol
- MSDS File:
- SDS
Melting point | 190-248°C |
---|---|
Flash point | 9℃ |
storage temp. | -20°C Freezer, Under Inert Atmosphere |
solubility | Soluble in DMSO. |
form | powder |
pka | 6.86±0.20(Predicted) |
color | Yellow |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
InChIKey | OGUCZBIQSYYWEF-UHFFFAOYSA-N |
FDA UNII | MZA8BK588J |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS06 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H301-H336 | |||||||||
Precautionary statements | P301+P310+P330 | |||||||||
Hazard Codes | Xn,T,F | |||||||||
Risk Statements | 22-36/37/38-39/23/24/25-23/24/25-11 | |||||||||
Safety Statements | 26-36-45-36/37-16-7 | |||||||||
RIDADR | UN 2811 6.1/PG 3 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | HP1760000 | |||||||||
HazardClass | 6.1(b) | |||||||||
PackingGroup | III | |||||||||
HS Code | 29335990 | |||||||||
NFPA 704 |
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CLOZAPINE N-OXIDE price More Price(34)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | C0832 | Clozapine N-oxide | 34233-69-7 | 5mg | $232 | 2024-03-01 | Buy |
Alfa Aesar | J67235 | Clozapine N-oxide, 99% | 34233-69-7 | 5mg | $186 | 2024-03-01 | Buy |
Cayman Chemical | 16882 | Clozapine N-oxide ≥98% | 34233-69-7 | 1mg | $36 | 2024-03-01 | Buy |
Cayman Chemical | 16882 | Clozapine N-oxide ≥98% | 34233-69-7 | 5mg | $62 | 2024-03-01 | Buy |
Sigma-Aldrich | SML2304 | Clozapine N-oxide hydrochloride ≥98% (HPLC), Water soluble Clozapine N-oxide | 34233-69-7 | 5mg | $225 | 2024-03-01 | Buy |
CLOZAPINE N-OXIDE Chemical Properties,Uses,Production
Description
Clozapine-N-oxide (34233-69-7) is a clozapine?metabolite1?which is pharmacologically inert2. Agonist at human muscarinic designer receptors known as DREADDs, (designer receptors exclusively activated by designer drug).2?May be used to control grafted human pluripotent stem cell-derived neurons engineered to express DREADDs.3,4??Numerous other applications.5,6
Chemical Properties
Yellow Solid
Uses
Clozapine N-oxide has been used:
- for the activation of human M4 muscarinic (hM4Di) in primary motor cortex
- for inducing in vivo chemogenetic manipulation and impairing locomotor activity in Th-cre transgenic mice
- in behavioral testing in mice and for stimulating (HEK293) cells
Uses
A 5-HT2 antagonist. A major metabolite of clozapine that can be monitored by HPLC. Possesses little or no activity towards serotonin receptors
Definition
ChEBI: Clozapine N-oxide is a dibenzodiazepine.
General Description
Clozapine N-oxide (CNO), inactive from of clozapine drug, activates G-protein-coupled receptors (GPCRs). CNO serves as a synthetic ligand for engineered human muscarinic receptor. It elicits clozapine-like effects upon metabolic conversion. Clozapine conversion to CNO favors its passage through blood-brain barrier.
Biochem/physiol Actions
5-HT2 serotonin receptor antagonist; major metabolite of clopazine that can be monitored by HPLC.
storage
Room temperature (desiccate)
References
1) Eiermann?et al.?(1997),?The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine; Br. J. Clin. Pharmacol.,?44?439 2) Armbruster?et al.?(2007),?Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand; Proc. Natl. Acad. Sci. USA,?104?5163 3) Chen?et al.?(2016),?Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson’s Disease; Cell Stem Cell,?18?817 4) Vazey and Aston-Jones (2014),?Designer receptors: therapeutic adjuncts to cell replacement therapy in Parkinson’s disease: J. Clin. Invest.,?124?2858 5) Gomez?et al.?(2017)?Chemogenetics revealed: DREADD occupancy and activation via converted clozapine; Science?357?503 6) Marcinkiewcz?et al. (2016)?Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala; Nature?537?97
CLOZAPINE N-OXIDE Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12450 | 58 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29825 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9321 | 58 |
Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12382 | 58 |
Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 |
View Lastest Price from CLOZAPINE N-OXIDE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2023-10-07 | Clozapine Noxide
34233-69-7
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
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2021-07-13 | Clozapine N-oxide
34233-69-7
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
![]() |
2021-07-09 | Clozapine N-oxide
34233-69-7
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Clozapine Noxide
34233-69-7
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Clozapine N-oxide
34233-69-7
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Clozapine N-oxide
34233-69-7
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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