N-DESMETHYLCLOZAPINE
- CAS No.
- 6104-71-8
- Chemical Name:
- N-DESMETHYLCLOZAPINE
- Synonyms
- NORCLOZAPINE;Desmethylclozapine;Norclozapine (ACP-104);Normethylclozapine;N-DESMETHYLCLOZAPINE;Clozapine EP IMpurity C;Clozapine Impurity C（EP）;Norclozapine in methanol;N-Desmethylclozapine;N-Desmethylclozapine solution
- CBNumber:
- CB8196019
- Molecular Formula:
- C17H17ClN4
- Molecular Weight:
- 312.8
- MDL Number:
- MFCD00210189
- MOL File:
- 6104-71-8.mol
| Melting point | 120-125°C |
|---|---|
| Boiling point | 502.6±60.0 °C(Predicted) |
| Density | 1.38±0.1 g/cm3(Predicted) |
| Flash point | 9℃ |
| storage temp. | Store at RT |
| solubility | Chloroform (Slightly), DMSO, Methanol (Slightly) |
| form | Yellow solid. |
| pka | 8.49±0.10(Predicted) |
| color | Light Yellow to Yellow |
| CAS DataBase Reference | 6104-71-8(CAS DataBase Reference) |
| FDA UNII | 1I9001LWY8 |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P301+P312-P302+P352-P304+P340+P312-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,T,F | |||||||||
| Risk Statements | 20/22-36/37/38-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 22-36-45-36/37-16-7 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| NFPA 704 |
|
N-DESMETHYLCLOZAPINE price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D5676 | N-Desmethylclozapine | 6104-71-8 | 5mg | $160 | 2024-03-01 | Buy |
| Sigma-Aldrich | D-048 | N-Desmethylclozapine solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? | 6104-71-8 | 1mL | $163 | 2024-03-01 | Buy |
| Cayman Chemical | 26153 | N-Desmethylclozapine | 6104-71-8 | 5mg | $92 | 2024-03-01 | Buy |
| Cayman Chemical | 26153 | N-Desmethylclozapine | 6104-71-8 | 100mg | $1078 | 2024-03-01 | Buy |
| Sigma-Aldrich | D5676 | N-Desmethylclozapine | 6104-71-8 | 10mg | $237 | 2024-03-01 | Buy |
N-DESMETHYLCLOZAPINE Chemical Properties,Uses,Production
Chemical Properties
Yellow Crystalline Solid
Uses
A major metabolite of Clozapine. A potent and selective 5-HT2C serotonin receptor antogonist.
Uses
N-Desmethylclozapine has been used as standard to quantify the clozapine plasma levels in treatment-refractory Chinese schizophrenic patients.
Uses
A major metabolite of Clozapine (C587500). A potent and selective 5-HT2C serotonin receptor antogonist.
Definition
ChEBI: A dibenzodoazepine substituted with chloro and piperazino groups which is a major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist.
General Description
N-Desmethylclozapine is an active metabolite of Clozapine, an atypical antipsychotic drug used for treatment of schizophrenia. Clozapine is sold under the trade names Clozaril? and FrazaClo in the US. This Certified Snap-N-Spike? Solution is suitable for use in urine drug testing, clinical toxicology, forensic analysis, and clinical monitoring by LC-MS/MS or GC/MS.
Biological Activity
A major metabolite of clozapine; a potent and selective 5-HT 2C serotonin receptor antagonist.
Biochem/physiol Actions
N-Desmethylclozapine serves as an agonist to muscarinic acetylcholine receptors, and is known to exert its antipsychotic action. It blocks synaptic transmission by antagonizing synaptic GABA (γ-aminobutyric acid) receptors.
storage
Room temperature
N-DESMETHYLCLOZAPINE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29730 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29808 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 |
| Supplier | Advantage |
|---|---|
| Capot Chemical Co.,Ltd. | 60 |
| ATK CHEMICAL COMPANY LIMITED | 60 |
| Standardpharm Co. Ltd. | 58 |
| career henan chemical co | 58 |
| TargetMol Chemicals Inc. | 58 |
| sgtlifesciences pvt ltd | 58 |
| InvivoChem | 58 |
| TargetMol Chemicals Inc. | 58 |
| LEAPCHEM CO., LTD. | 58 |
| Aladdin Scientific | 58 |
View Lastest Price from N-DESMETHYLCLOZAPINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | N-Desmethyl clozapine-d8 Hydrochloride | US $485.00-2420.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2024-11-17 | N-Desmethylclozapine
6104-71-8
|
US $43.00-163.00 / mg | 97.25% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-01-03 | N-DESMETHYLCLOZAPINE
6104-71-8
|
US $6.60 / KG | 1KG | 97%-99% | 1kg -1000kg | Career Henan Chemical Co |
-
- N-Desmethyl clozapine-d8 Hydrochloride
- US $485.00-2420.00 / mg
- TargetMol Chemicals Inc.
-
- N-Desmethylclozapine
6104-71-8
- US $43.00-163.00 / mg
- 97.25%
- TargetMol Chemicals Inc.
-
- N-DESMETHYLCLOZAPINE
6104-71-8
- US $6.60 / KG
- 97%-99%
- Career Henan Chemical Co