Fendiline
- CAS No.
- 13042-18-7
- Chemical Name:
- Fendiline
- Synonyms
- N-(1-Phenylethyl)-3,3-diphenylpropylamine;3,3-diphenyl-N-(1-phenylethyl)propan-1-amine;Benzenepropanamine, γ-phenyl-N-(1-phenylethyl)-
- CBNumber:
- CB4874928
- Molecular Formula:
- C23H25N
- Molecular Weight:
- 315.45
- MDL Number:
- MOL File:
- 13042-18-7.mol
| Boiling point | bp0.3 206-210° |
|---|---|
| Density | 1.031±0.06 g/cm3(Predicted) |
| pka | 9.49±0.28(Predicted) |
| Water Solubility | 2.331mg/L(22.5 ºC) |
| FDA UNII | S253D559A8 |
Fendiline Chemical Properties,Uses,Production
Originator
Sensit,Thiemann,W. Germany,1974
Definition
ChEBI: 3,3-diphenyl-N-(1-phenylethyl)-1-propanamine is a diarylmethane.
Manufacturing Process
21.13 grams of γ,γ-diphenyl-propylamine and 12.01 grams of acetophenone
are hydrogenated in 200 ml of methanol at 55°C and a pressure of 10
atmospheres in the presence of palladium charcoal. On filtration of the
catalyst the solution is concentrated and the remainder is distilled in vacuo at
a pressure of 0.3 Hg mm. The main distillate is collected at 206° to 210°C.
25.38 grams of N-[1'-phenylethyl-(1')]-1,1-diphenyl-propyl-(3)-amine are
obtained.
The product is dissolved in 134 ml of 96% ethanol whereupon 26.8 ml of
concentrated hydrochloric acid and 201 ml of water are added while cooling
with ice-water. The precipitate is filtered off and dried in vacuo at 100°C.
22.98 grams of N-[1'-phenylethyl)-(1')]-1,1-diphenyl-propyl-(3)-amine
hydrochloride are obtained. MP 200° to 201°C. On recrystallization from 285
ml of a 2:1 mixture of water and 96% ethanol the melting point remains
unchanged.
Therapeutic Function
Coronary vasodilator
Fendiline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9003 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28118 | 58 |
| Supplier | Advantage |
|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 58 |
| Alchem Pharmtech,Inc. | 58 |
| Shaanxi Didu New Materials Co. Ltd | 58 |
| TargetMol Chemicals Inc. | 58 |