tolonidine
- CAS No.
- 4201-22-3
- Chemical Name:
- tolonidine
- Synonyms
- ST-375;tolonidine;N-(2-Chloro-4-methylphenyl)-4,5-dihydro-1H-imidazol-2-amine;1H-Imidazol-2-amine, N-(2-chloro-4-methylphenyl)-4,5-dihydro-
- CBNumber:
- CB4875314
- Molecular Formula:
- C10H12ClN3
- Molecular Weight:
- 209.68
- MDL Number:
- MOL File:
- 4201-22-3.mol
| Melting point | 148-150° |
|---|---|
| Boiling point | 314.0±52.0 °C(Predicted) |
| Density | 1.31±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 9.41(at 25℃) |
| form | Solid |
| color | White to off-white |
| FDA UNII | I4O795Q03O |
| ATC code | C02AC04 |
tolonidine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | SYN5523 | Tolonidine | 4201-22-3 | 10mg | $104 | 2021-12-16 | Buy |
| AK Scientific | SYN5523 | Tolonidine | 4201-22-3 | 50mg | $336 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0012694 | TOLONIDINE 95.00% | 4201-22-3 | 5MG | $495.19 | 2021-12-16 | Buy |
tolonidine Chemical Properties,Uses,Production
Originator
Euctan,Essex,Switz.,1978
Definition
ChEBI: Tolonidine is a substituted aniline.
Manufacturing Process
43 g of the thiourea compound (melting point 124°C) obtained in known
fashion from 2-chloro-4-methylaniline and ammonium thiocyanate and 20 cc
of methyl iodide were dissolved in 200 cc of methanol, and the solution was
refluxed for two hours.1 Thereafter, the solvent was evaporated in vacuo,
leaving 73.2 g of the isothiouronium hydroiodide of the formula as a residue.
This isothiouronium salt was admixed with 20 cc of ethylenediamine, and the
mixture was heated for about 30 minutes at 150°C to 160°C, accompanied by
stirring; methyl mercaptan escaped during that time. Subsequently, the
reaction mixture was taken up in hot dilute acetic acid, and the resulting
solution was made alkaline with 2 N sodium hydroxide. A precipitate formed,
which was separated by vacuum filtration, washed with water and dried. It
was identified to be 2-(2'-chloro-4'-methylphenyl)-amino-1,3-
diazacyclopentene-(2) having a melting point of 142°C to 145°C. The yield
was 10.2 g.
The nitrate of the base, obtained by acidifying a solution of the free base with
nitric acid, had a melting point of 162°C to 164°C and was soluble in water
and methanol.
Therapeutic Function
Antihypertensive
tolonidine Preparation Products And Raw materials
Raw materials
Preparation Products
tolonidine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19885 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29785 | 68 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11217 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29774 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24647 | 58 |
View Lastest Price from tolonidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-24 | Tolonidine
4201-22-3
|
US $74.00 / mg | 10g | TargetMol Chemicals Inc. |
-
- Tolonidine
4201-22-3
- US $74.00 / mg
- TargetMol Chemicals Inc.