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Phenobarbital sodium

Phenobarbital sodium structure

CAS No.: 57-30-7

Chemical Name:: Phenobarbital sodium

Synonyms: sodiumluminal;LUMINAL SODIUM;gardenalsodium;phenobalsodium;phenobarbitalna;solphenobarbital;solphenobarbitone;LUMINAL SODIUM SALT;fenobarbitalnatrium;phenobarbitalelixir

CBNumber:: CB5147742

Molecular Formula:: C12H12N2O3.Na

Molecular Weight:: 254.22

MDL Number:: MFCD00036211

MOL File:: 57-30-7.mol

MSDS File:: SDS

Last updated:2023-05-15 10:43:58

Phenobarbital sodium Properties

Melting point	175°C
solubility	H₂O: 1 g/mL
form	Solid
color	White to Off-White
PH	pH (100g/l, 25℃) : 9.0～11.0
Water Solubility	>=10 g/100 mL at 20 ºC
Merck	13,7319
BRN	3802044
Stability	Hygroscopic
CAS DataBase Reference	57-30-7(CAS DataBase Reference)
FDA UNII	SW9M9BB5K3
EPA Substance Registry System	Phenobarbital sodium (57-30-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06,GHS08
Signal word	Danger
Hazard statements	H301-H317-H351
Precautionary statements	P202-P261-P264-P280-P301+P310-P302+P352
Hazard Codes	T
Risk Statements	25-40-43
Safety Statements	22-36/37/39-45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	-
RTECS	CQ7000000
HazardClass	6.1(b)
PackingGroup	III
Toxicity	LD50 orally in rats: 660 mg/kg (Schaffarzick, Brown)

Phenobarbital sodium Chemical Properties,Uses,Production

Chemical Properties

Solution S is clear (2.2.1) and not more intensely coloured than reference solution Y7 (2.2.2, Method II).

Uses

Phenobarbital sodium salt has been used:

to anesthetize mice for inducing ischemia-reperfusion injury
as a positive control for the activation of constitutive androstane receptor (CAR)
in bioluminescent yeast bioreporters (BLYAS) assay

Uses

Anticonvulsant; sedative-hypnotic.

Definition

ChEBI: A barbiturate that is the sodium salt of phenobarbital (barbituric acid substituted at C-5 by ethyl and phenyl groups).

brand name

Luminal Sodium (Sterling Winthrop).

General Description

Odorless white crystalline powder. Aqueous solutions are alkaline to litmus and phenolphthalein (pH approximately 9.3). Bitter taste. A narcotic.

Air & Water Reactions

Hygroscopic. May be sensitive to prolonged exposure to air. Water soluble. Aqueous solutions are unstable, but may be kept at or below 50°F for a few days.

Reactivity Profile

Phenobarbital sodium can react with strong oxidizing agents. Incompatible with ammonium salts and chloral hydrate. Also incompatible with acids and acidic substances .

Fire Hazard

Flash point data for Phenobarbital sodium are not available; however, Phenobarbital sodium is probably combustible.

Biochem/physiol Actions

Phenobarbital, a substituted barbituric acid is an antileptic drug and is not easily eliminated from circulation. It hyperpolarizes the synaptic neuronal membranes by favoring the activation of neuronal postsynaptic GABAA?receptors by γ aminobutyric acid (GABA). Phenobarbital is also effective in treating neonatal seizures and status epilepticus.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by ingestion, intravenous, intraperitoneal, intraduodenal, and subcutaneous routes. Human systemic effects by ingestion: nausea or vomiting and coma. Experimental reproductive effects. Mutation data reported. Used to treat epilepsy, as a hypnotic and sedative. When heated to decomposition it emits toxic fumes of NOx and NazO. See also BARBITURATES

Phenobarbital sodium synthesis

Synthesis of Phenobarbital sodium from Phenobarbital

Phenobarbital sodium Preparation Products And Raw materials

Raw materials

Preparation Products

Phenobarbital 1(2H)-Pyrimidinebutanoic acid, 5-ethyltetrahydro-2,4,6-trioxo-5-phenyl-, ethyl ester

57-30-7(Phenobarbital sodium )Related Search:

Sodium hydroxide Ethanol Ethyl acetate Sodium benzoate Ethyl maltol

Sodium acetate Triphenylphosphine Ethyl acrylate Sodium bicarbonate Ethyl cyanoacetate

Ethylparaben Hydroxyethyl Cellulose Sodium citrate ISOXADIFEN-ETHYL 5,5-DIETHYLBARBITURIC ACID SODIUM SALT

PHENYL VALERATE Ethyl cellulose 2-Phenylphenol

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solublephenobarbitone LUMINAL SODIUM LUMINAL SODIUM SALT 5-ETHYL-5-PHENYL-2,4,6-TRIOXOHEXAHYDROPYRIMIDINE SODIUM SALT 5-ETHYL-5-PHENYLBARBITURIC ACID SODIUM SALT 5-ethyl-5-phenyl-2,4,6-(1h,3h,5h)pyrimidinetrione monosodium salt SODIUM 5-ETHYL-5-PHENYLBARBITURATE PHENOBARBITAL SODIUM PHENOBARBITAL SODIUM SALT PHENOBARBITONE SODIUM PHENOBARBITAL, SODIUM--DEA SCHEDULE*IV I TEM PHENOBARBITAL SODIUM ANESTHETIC,SEDATIVE ,H 4,6(1h,3h,5h)-pyrimidinetrione,5-ethyl-5-phenyl-monosodiumsalt 5-Ethyl-5-phenyl-2,4,6-trioxohexahydropyrimidine sodium salt, 5-Ethyl-5-phenylbarbituric acid sodium salt, Luminal sodium salt, Sodium 5-ethyl-5-phenylbarbiturate 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-phenyl-, monosodium salt 5-Ethyl-5-phenylbarbituric acid sodium Sodium ethylphenylbarbiturat Phenobarbital Sodium Salt (contains 5% Isopropyl Alcohol at maximum) 5-Ethyl-5-phenyl-2-sodiooxy-4,6(1H,5H)-pyrimidinedione Phenobarbital sodium salt,5-Ethyl-5-phenyl-2,4,6-trioxohexahydropyrimidine sodium salt, 5-Ethyl-5-phenylbarbituric acid sodium salt, Luminal sodium salt, Sodium 5-ethyl-5-phenylbarbiturate Phenobarbital SodiuM API 2,4,6(1H,3H,5H)-PyriMidinetrione,5-ethyl-5-phenyl-, sodiuM salt (1:1) fenobarbitalnatrium PHENOBARBITALSODIUM,USP 5-ETHYL-5-PHENYLBARBITURICACIDSODIUMSALT(PHENOBARBITALSODIUM) 5-ethyl-5-phenyl-barbituricacisodiumsalt gardenalsodium phenobalsodium phenobarbitalelixir phenobarbitalna phenobarbitonesodiumsalt phenyl-aethyl-barbitursaeurenatrium phenylethylbarbituricacid,sodiumsalt sodiumluminal sodiumphenobarbital sodiumphenobarbitone sodiumphenylethylbarbiturate sodiumphenylethylmalonylurea solphenobarbital solphenobarbitone solublephenobarbital Phenobarbital sodium USP/EP/BP Pramoxine Impurity 11 57-30-7 C12H11N2O3Na C12H12N2O3Na Cell Signaling Enzymes Application Index Building Blocks Biochemicals and Reagents BioChemical Heterocyclic Building Blocks Enzymes, Inhibitors, and Substrates Xenobiotics and Drug Metabolism Substrates Pyrimidines Heterocyclic Compounds