Solution S is clear (2.2.1) and not more intensely coloured than reference solution Y7 (2.2.2, Method II).
용도
Phenobarbital sodium salt has been used:
to anesthetize mice for inducing ischemia-reperfusion injury
as a positive control for the activation of constitutive androstane receptor (CAR)
in bioluminescent yeast bioreporters (BLYAS) assay
정의
ChEBI: A barbiturate that is the sodium salt of phenobarbital (barbituric acid substituted at C-5 by ethyl and phenyl groups).
일반 설명
Odorless white crystalline powder. Aqueous solutions are alkaline to litmus and phenolphthalein (pH approximately 9.3). Bitter taste. A narcotic.
공기와 물의 반응
Hygroscopic. May be sensitive to prolonged exposure to air. Water soluble. Aqueous solutions are unstable, but may be kept at or below 50°F for a few days.
반응 프로필
Phenobarbital sodium can react with strong oxidizing agents. Incompatible with ammonium salts and chloral hydrate. Also incompatible with acids and acidic substances .
화재위험
Flash point data for Phenobarbital sodium are not available; however, Phenobarbital sodium is probably combustible.
Safety Profile
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by ingestion, intravenous, intraperitoneal, intraduodenal, and subcutaneous routes. Human systemic effects by ingestion: nausea or vomiting and coma. Experimental reproductive effects. Mutation data reported. Used to treat epilepsy, as a hypnotic and sedative. When heated to decomposition it emits toxic fumes of NOx and NazO. See also BARBITURATES
