2-AMINO-BETA-NAPHTHOTHIAZOLE
- CAS No.
- 40172-65-4
- Chemical Name:
- 2-AMINO-BETA-NAPHTHOTHIAZOLE
- Synonyms
- SKA 31;-2-amine;AKOS BBS-00006561;IFLAB-BB F1386-0401;naphtho[1,2-d]thiazoL;SKA-31, 10 mM in DMSO;LABOTEST-BB LT00154570;2-Amino-β-naphthothiazole;2-AMINONAPHTHO-1,2-THIAZOLE;2-AMINO-BETA-NAPHTHOTHIAZOLE
- CBNumber:
- CB5244427
- Molecular Formula:
- C11H8N2S
- Molecular Weight:
- 200.26
- MDL Number:
- MFCD00051329
- MOL File:
- 40172-65-4.mol
- MSDS File:
- SDS
| Melting point | 184-188°C |
|---|---|
| Boiling point | 417.1±28.0 °C(Predicted) |
| Density | 1.403±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | DMSO: ≥30mg/mL |
| form | solid |
| pka | 3.50±0.30(Predicted) |
| color | Off-white |
| Stability | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| CAS DataBase Reference | 40172-65-4(CAS DataBase Reference) |
| FDA UNII | SW12CAS9T7 |
| EPA Substance Registry System | Naphtho[1,2-d]thiazol-2-amine (40172-65-4) |
| UNSPSC Code | 12352202 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P305+P351+P338-P337+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38-36-22 | |||||||||
| Safety Statements | 22-36/37/39-26 | |||||||||
| NFPA 704 |
|
2-AMINO-BETA-NAPHTHOTHIAZOLE price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S5576 | SKA-31 ≥98% (HPLC) | 40172-65-4 | 5mg | $130 | 2024-03-01 | Buy |
| Sigma-Aldrich | S5576 | SKA-31 ≥98% (HPLC) | 40172-65-4 | 25mg | $721 | 2024-03-01 | Buy |
| Cayman Chemical | 29690 | SKA-31 | 40172-65-4 | 5mg | $53 | 2024-03-01 | Buy |
| Cayman Chemical | 29690 | SKA-31 | 40172-65-4 | 10mg | $92 | 2024-03-01 | Buy |
| Cayman Chemical | 29690 | SKA-31 | 40172-65-4 | 25mg | $213 | 2024-03-01 | Buy |
2-AMINO-BETA-NAPHTHOTHIAZOLE Chemical Properties,Uses,Production
Description
SKA-31 (40172-65-4) is a KCa3.1 and KCa2 potassium channel activator (EC50 =260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively). Enhanced acetylcholine-induced EDHF dilator response in mouse carotid arteries and lowers blood pressure in mouse models at 30 mg/Kg.1,2 Evokes robust vasodilation in rat mesenteric arteries.3
Biological Activity
Activator of K Ca 3.1 and K Ca 2 channels (EC 50 values are 260, 2900, 2900 nM for K Ca 3.1, K Ca 2.1 and K Ca 2.2 respectively). Potentiates acetylcholine-induced EDHF-type dilations of mouse carotid arteries and lowers blood pressure in normotensive and hypertensive mice.
storage
+4°C
References
Sankaranaravanan et al. (2009), Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure; Mol. Pharmacol., 75 281 Brahler et al. (2009), Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator and causes hypertension ; Circulation, 119 2323 Khaddaj-Mallat al. (2018), SKA-31, an activator of endothelial Ca2+-activated K+ channels evokes robust vasodilation in rat mesenteric arteries; Eur. J. Pharmacol., 831 60
2-AMINO-BETA-NAPHTHOTHIAZOLE Preparation Products And Raw materials
2-AMINO-BETA-NAPHTHOTHIAZOLE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32965 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49476 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30233 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| ORGANICA Feinchemie GmbH | +49 3494636389 | info@organica.de | Germany | 598 | 65 |
