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(R)-SLV 319

(R)-SLV 319 Structure
(R)-SLV 319 structure
CAS No.
656827-86-0
Chemical Name:
(R)-SLV 319
Synonyms
(R)-SLV 319;SLV 319, (R)-(+)-;(4R)-5-(4-chlorophenyl)-N-(4-chlorophenyl)sulfonyl-N'-methyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide;4-chloro-N-{[3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-pyrazol-1-yl]-methylamino-methylene}-benzenesulfonamide;1H-Pyrazole-1-carboximidamide, 3-(4-chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4-phenyl-, (4R)-
CBNumber:
CB52453032
Molecular Formula:
C23H20Cl2N4O2S
Molecular Weight:
487.4
MDL Number:
MFCD09951896
MOL File:
656827-86-0.mol
Last updated:2024-11-20 11:41:24
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(R)-SLV 319 Properties

Boiling point 623.2±65.0 °C(Predicted)
Density 1.38±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
form crystalline solid
pka 11?+-.0.60(Predicted)

(R)-SLV 319 price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10009227 (R)-SLV 319 ≥98% 656827-86-0 1mg $81 2024-03-01 Buy
Cayman Chemical 10009227 (R)-SLV 319 ≥98% 656827-86-0 5mg $317 2024-03-01 Buy
Cayman Chemical 10009227 (R)-SLV 319 ≥98% 656827-86-0 10mg $475 2024-03-01 Buy
Cayman Chemical 10009227 (R)-SLV 319 ≥98% 656827-86-0 50mg $1344 2021-12-16 Buy
ApexBio Technology C5122 (R)-SLV319 656827-86-0 50mg $1863 2021-12-16 Buy
Product number Packaging Price Buy
10009227 1mg $81 Buy
10009227 5mg $317 Buy
10009227 10mg $475 Buy
10009227 50mg $1344 Buy
C5122 50mg $1863 Buy

(R)-SLV 319 Chemical Properties,Uses,Production

Description

Central cannabinoid (CB1) receptor antagonists may have potential in the treatment of a number of diseases such as neuroinflammatory disorders, cognitive disorders, septic shock, obesity, psychosis, addiction, and gastrointestinal disorders. (R)-SLV 319 is the inactive enantiomer of SLV 319 with 100-fold less affinity for the CB1 receptor. SLV 319 is a potent and selective CB1 receptor antagonist with Ki values of 7.8 and 7,943 nM for CB1 and peripheral cannabinoid (CB2) receptors, respectively. SLV 319 is less lipophilic (log P = 5.1) and therefore more water soluble than other known CB1 receptor ligands.

in vitro

(r)-slv 319 is the inactive enantiomer of slv 319 with 100-fold less affinity for the cb1 receptor. slv 319 was identified as a potent and selective cb1 receptor antagonist with ki values of 7.8 and 7,943 nm for cb1 and peripheral cannabinoid (cb2) receptors, respectively. slv 319 was found to be less lipophilic and thus more water soluble than other known cb1 receptor ligands [1,2].

in vivo

a previous animal study examined the chronic effects of slv 319 in hyperinsulinemic zucker rats to determine their chronic effects on insulinemia. results showed that r slv 319 at 10 mg·kg-1·day-1 elicited body weight-independent improvements in insulinemia and glycemia during 10 wk of chronic treatment. moreover, slv 319 treatment caused glucose intolerance in cb1 but not sur1-ko mice [3].

References

[1] lange, j. h.m.,coolen, h.k.a.c.,van stuivenberg, h.h., et al. synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective cb1 cannabinoid receptor antagonists. journal of medicinal chemistry 47(3), 627-643 (2004).
[2] lange, j. h.m.,van stuivenberg, h.h.,veerman, w., et al. novel 3,4-diarylpyrazolines as potent cannabinoid cb1 receptor antagonists with lower lipophilicity. bioorganic & medicinal chemistry letters 15, 4794-4798 (2005).
[3] lynch cj, zhou q, shyng sl, heal dj, cheetham sc, dickinson k, gregory p, firnges m, nordheim u, goshorn s, reiche d, turski l, antel j. some cannabinoid receptor ligands and their distomers are direct-acting openers of sur1 k(atp) channels. am j physiol endocrinol metab. 2012 mar 1;302(5):e540-51.

(R)-SLV 319 Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-SLV 319 Suppliers

Global( 28)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
BOC Sciences -- info@bocsci.com USA 0 65
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11217 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369 3477467573@qq.com China 8617 58
Anqing Rong Chuang Biological Technology Co., Ltd. 15001988657 1367753897@qq.com China 987 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24647 58
Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd 18162595016; 18162595016 3287908757@qq.com China 9122 58
ApexBio Technology -- sales@apexbt.com United States 6251 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Shanghai EFE Biological Technology Co., Ltd. 58
BOC Sciences 65
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Changzhou Furuisi Biotechnology Co., Ltd 58
Anqing Rong Chuang Biological Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd 58
ApexBio Technology 58

View Lastest Price from (R)-SLV 319 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(R)-SLV 319 pictures 2024-11-21 (R)-SLV 319
656827-86-0
 US $793.00-1180.00 / mg 10g TargetMol Chemicals Inc.
  • (R)-SLV 319 pictures
  • (R)-SLV 319
    656827-86-0
  • US $793.00-1180.00 / mg
  • TargetMol Chemicals Inc.

656827-86-0((R)-SLV 319)Related Search:

(R)-SLV 319 3-(4-CHLOROPHENYL)-4-PHENYL-1H PYRAZOLE
(R)-SLV 319 (4R)-5-(4-chlorophenyl)-N-(4-chlorophenyl)sulfonyl-N'-methyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide 4-chloro-N-{[3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-pyrazol-1-yl]-methylamino-methylene}-benzenesulfonamide 1H-Pyrazole-1-carboximidamide, 3-(4-chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4-phenyl-, (4R)- SLV 319, (R)-(+)- 656827-86-0