3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone
- CAS No.
- 491871-58-0
- Chemical Name:
- 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone
- Synonyms
- CS-1482;TCS PIM-1;SC 204330;TCS PIM-1 1;TCS PIM-1 1, >=98%;TCS PIM-1 1(sc-204330);SC 204330; TCS PIM 1-1;TCS PIM-1 1, 10 mM in DMSO;3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone;6-(5-Bromo-2-hydroxyphenyl)-1,2-dihydro-2-oxo-4-phenyl-3-pyridinecarbonitrile
- CBNumber:
- CB52518751
- Molecular Formula:
- C18H11BrN2O2
- Molecular Weight:
- 367.2
- MDL Number:
- MFCD00276275
- MOL File:
- 491871-58-0.mol
- MSDS File:
- SDS
| Boiling point | 592.6±50.0 °C(Predicted) |
|---|---|
| Density | 1.63±0.1 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | insoluble in H2O; insoluble in EtOH; ≥12.8 mg/mL in DMSO |
| form | solid |
| pka | 6.93±0.10(Predicted) |
| color | Light yellow to yellow |
3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16286 | TCS PIM-1 1 ≥98% | 491871-58-0 | 5mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 16286 | TCS PIM-1 1 ≥98% | 491871-58-0 | 10mg | $155 | 2024-03-01 | Buy |
| Cayman Chemical | 16286 | TCS PIM-1 1 ≥98% | 491871-58-0 | 50mg | $360 | 2024-03-01 | Buy |
| Cayman Chemical | 16286 | TCS PIM-1 1 ≥98% | 491871-58-0 | 100mg | $672 | 2024-03-01 | Buy |
| Tocris | 2979 | TCSPIM-11 ≥98%(HPLC) | 491871-58-0 | 50 | $716 | 2021-12-16 | Buy |
3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone Chemical Properties,Uses,Production
Uses
TCS PIM-1 1 is a Pim-1 kinase inhibitor.
Definition
ChEBI: 3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)-2-pyridone is a member of the class of pyridones that is 2-pyridone carrying cyano, phenyl and 3-bromo-6-hydroxyphenyl substituents at positions 3, 4 and 6 respectively It is a pyridone, a bromophenol and a nitrile.
Biological Activity
tcs pim-1 1 is a selective inhibitor of pim-1 with ic50 value of 50 nm [1].pim-1 is a proto-oncogene serine/threonine-protein kinase and plays an important role in cell cycle progression, apoptosis, transcriptional activation and more general signal transduction pathways. it has been shown that pim-1 over-expression is correlated with a variety of human cancers [2].tcs pim-1 1 is a potent pim-1 inhibitor and has a better selectivity to pim-1 than to pim-2. it was revealed that tcs pim-1 1 was the most potent inhibitor of pim-1 by outlining the crystal structure and it was also shown that tcs pim-1 1 had better inhibitory activity to pim-1 compared with pim-2 [1].
IC 50
PIM1: 50 nM (IC50)
storage
Store at +4°C
References
[1]. cheney, i.w., et al., identification and structure-activity relationships of substituted pyridones as inhibitors of pim-1 kinase. bioorg med chem lett, 2007. 17(6): p. 1679-83.
[2]. cen, b., et al., the pim-1 protein kinase is an important regulator of met receptor tyrosine kinase levels and signaling. mol cell biol, 2014. 34(13): p. 2517-32.
3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29808 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32202 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
View Lastest Price from 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-12-24 | 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone
491871-58-0
|
US $1.00 / g | 1g | 99% | 20kg | Career Henan Chemical Co |
-
- 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone
491871-58-0
- US $1.00 / g
- 99%
- Career Henan Chemical Co