ChemicalBook >> CAS DataBase List >>4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester

4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester

CAS No.
1144035-53-9
Chemical Name:
4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester
Synonyms
CS-894;PF 8380;PF-8380 HCL;PF 8380; PF8380;PF-8380, ATX Inhibitor;PF-8380;PF 8380;PF8380;Autotaxin Inhibitor III, PF-8380;Autotaxin Inhibitor III, PF-8380 - CAS 1144035-53-9 - Calbiochem;3,5-Dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)propyl)piperazine-1-ca.;3,5-Dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo-[d]oxazol-6-yl)propyl)piperazine-1-carbo
CBNumber:
CB52589638
Molecular Formula:
C22H21Cl2N3O5
Molecular Weight:
478.33
MDL Number:
MFCD20527274
MOL File:
1144035-53-9.mol
MSDS File:
SDS
Last updated:2024-10-31 18:15:48

4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester Properties

Density 1.419
storage temp. -20°C
solubility DMSO: soluble5mg/mL, clear (warmed)
form Tan powder
pka 8.74±0.70(Predicted)
color white to beige
InChIKey JMSUDQYHPSNBSN-UHFFFAOYSA-N
FDA UNII T582DIM5A4

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335-H413
Precautionary statements  P261-P305+P351+P338
WGK Germany  3

4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0715 PF-8380 ≥98% (HPLC) 1144035-53-9 5mg $125 2024-03-01 Buy
Sigma-Aldrich 189512 Autotaxin Inhibitor III, PF-8380 1144035-53-9 10mg $259 2024-03-01 Buy
Cayman Chemical 12018 PF-8380 ≥95% 1144035-53-9 1mg $48 2024-03-01 Buy
Cayman Chemical 12018 PF-8380 ≥95% 1144035-53-9 5mg $131 2024-03-01 Buy
Sigma-Aldrich SML0715 PF-8380 ≥98% (HPLC) 1144035-53-9 25mg $478 2024-03-01 Buy
Product number Packaging Price Buy
SML0715 5mg $125 Buy
189512 10mg $259 Buy
12018 1mg $48 Buy
12018 5mg $131 Buy
SML0715 25mg $478 Buy

4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester Chemical Properties,Uses,Production

Uses

PF-8380 has been used in biological assays. It has also been used to estimate the role of intestinally-derived lysophosphatidic acid in dyslipidemia and atherosclerosis.

Uses

PF8380 is a novel autotaxin inhibitor which reduces lysophosphatidic acid levels in plasma and at the site of inflammation.

General Description

An orally bioavailable piperazinylbenzoxazolone compound that acts as a substrate competitive and tight-binding inhibitor of autotaxin activity {IC50 = 2.8 and 1.7 nM for recombinant human enzyme-β isoform employing FS-3 and LPC (lysophosphatidylcholine) as substrates, respectively; 1.16 and 1.15 nM for rat/murine enzyme-FS-3 and fetal fibroblast cell-LPC; 101 nM for human whole blood}. Displays desirable pharmacokinetics properties and efficiently blocks inflammation-induced LPA (lysophosphatidic acid) production both in plasma and at the site of inflammation by 95% in rat adjuvant-induced arthritis model (30 mg/kg, p.o.).

Biological Activity

pf-8380 is a specific and potent inhibitor of autotaxin (atx) with an ic50 value of 2.8 nm [1].autotaxin (atx) is a secreted enzyme having lysophospholipase d activity

Biochem/physiol Actions

PF-8380 [6-(3-(piperazin-1-yl)propanoyl)benzo[d]oxazol-2(3H)-one] has the ability to change the resistant and invasive features of glioblastoma and helps to improve the response to radiation therapy.

4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 130)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou FandaChem Co.,Ltd.
+8615858145714 FandaChem@Gmail.com China 9220 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32820 60
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29815 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32038 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Hefei Hirisun Pharmatech Co., Ltd
+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58

View Lastest Price from 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PF-8380 pictures 2024-10-31 PF-8380
1144035-53-9
US $38.00-137.00 / mg 99.45% 10g TargetMol Chemicals Inc.
4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester pictures 2020-01-14 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester
1144035-53-9
US $9.80 / KG 1g ≥99% 100kg Career Henan Chemical Co
  • PF-8380 pictures
  • PF-8380
    1144035-53-9
  • US $38.00-137.00 / mg
  • 99.45%
  • TargetMol Chemicals Inc.

4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester Spectrum

PF 8380 3,5-dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)propyl)piperazine-1-carboxylate 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester 3,5-Dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo-[d]oxazol-6-yl)propyl)piperazine-1-carboxyl PF-8380, ATX Inhibitor 3,5-Dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)propyl)piperazine-1-ca. 3,5-dichlorobenzyl 4-[3-oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-2-carboxylate 4-[3-(2,3-Dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-1-piperazinecarboxylic acid (3,5-dichlorophenyl)methyl ester 3,5-dichlorobenzyl 4-[3-oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylate PF-8380;PF 8380;PF8380 3,5-Dichlorobenzyl 4-[3-oxo-3-(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)propyl]-1-piperazinecarboxylate 3,5-Dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo-[d]oxazol-6-yl)propyl)piperazine-1-carbo Autotaxin Inhibitor III, PF-8380 PF-8380 HCL Autotaxin Inhibitor III, PF-8380 - CAS 1144035-53-9 - Calbiochem PF 8380; PF8380 CS-894 1-Piperazinecarboxylic acid, 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-, (3,5-dichlorophenyl)methyl ester (3,5-dichlorophenyl)methyl4-(3-oxo-3-(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)propyl)piperazine-1-carboxylate 1144035-53-9