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PF-3450074

PF-3450074 Structure
PF-3450074 structure
CAS No.
1352879-65-2
Chemical Name:
PF-3450074
Synonyms
PF74;PF-3450074;PF 3450074;PF74 >=98% (HPLC);PF-3450074, 10 mM in DMSO;(S)-N-Methyl-2-(2-(2-methyl-1H-indol-3-yl)acetamido)-N,3-diphenylpropanamide;(2S)-N-methyl-2-[2-(2-methyl-1H-indol-3-yl)acetamido]-N,3-diphenylpropanamide;2-Methyl-N-[(1S)-2-(methylphenylamino)-2-oxo-1-(phenylmethyl)ethyl]- 1H-indole-3-acetamide;1H-Indole-3-acetamide, 2-methyl-N-[(1S)-2-(methylphenylamino)-2-oxo-1-(phenylmethyl)ethyl]-;capsid protein,inhibit,PBMC,PF74,Human immunodeficiency virus,Inhibitor,PF-3450074,PF 3450074,PF 74,HIV,PF3450074
CBNumber:
CB82751081
Molecular Formula:
C27H27N3O2
Molecular Weight:
425.52
MDL Number:
MFCD28160729
MOL File:
1352879-65-2.mol
MSDS File:
SDS
Last updated:2025-04-18 09:52:52
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PF-3450074 Properties

storage temp. 2-8°C
solubility DMSO: soluble5mg/mL, clear (warmed)
form powder
color white to beige
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
WGK Germany  3

PF-3450074 price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0835 PF74 ≥98% (HPLC) 1352879-65-2 5mg $118 2024-03-01 Buy
Sigma-Aldrich SML0835 PF74 ≥98% (HPLC) 1352879-65-2 25mg $479 2024-03-01 Buy
ChemScene CS-0069433 PF-3450074 99.20% 1352879-65-2 100mg $720 2021-12-16 Buy
AK Scientific SYN5021 PF74 1352879-65-2 100mg $730 2021-12-16 Buy
ChemScene CS-0069433 PF-3450074 99.20% 1352879-65-2 10mg $140 2021-12-16 Buy
Product number Packaging Price Buy
SML0835 5mg $118 Buy
SML0835 25mg $479 Buy
CS-0069433 100mg $720 Buy
SYN5021 100mg $730 Buy
CS-0069433 10mg $140 Buy

PF-3450074 Chemical Properties,Uses,Production

Uses

PF-3450074 (PF-74) is a specifical inhibitor of HIV-1 capsid protein (CA) and displays a broad-spectrum inhibition of HIV isolates with submicromolar potency (EC50=8-640 nM). PF-3450074 (PF-74) acts at an early stage of HIV-1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle[1][2]. CPSF6: nuclear host factors cleavage and polyadenylation specific factor 6; NUP153: nucleoporin 153.

Biological Activity

PF74 (PF-3450074) is a HIV-1 inhibitor th at targets HIV capsid protein. PF74 binds specifically to HIV-1 particles and triggers premature HIV-1 uncoating in target cells.

IC 50

HIV-1 (NL4.3 strain): 0.72 μM (IC50)

References

[1] Xu JP, et al. Exploring?Modifications?of an?HIV-1?Capsid?Inhibitor:?Design,?Synthesis, and?Mechanism?of?Action.J Drug Des Res.?2018;5(2). pii: 1070. Epub 2018 Aug 13. PMID:30393786
[2] Shi J, et al. Small-molecule inhibition of human immunodeficiency virus type 1 infection by virus capsid destabilization.J Virol. 2011 Jan;85(1):542-9. DOI:10.1128/JVI.01406-10

PF-3450074 Preparation Products And Raw materials

Raw materials

Preparation Products

PF-3450074 Suppliers

Global( 47)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30231 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4601 55
Pharmacodia (Beijing) Co.,Ltd +86-400-851-9921 sales@pharmacodia.com China 2317 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
InvivoChem 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Pharmacodia (Beijing) Co.,Ltd 55
Shanghai EFE Biological Technology Co., Ltd. 58

View Lastest Price from PF-3450074 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PF-3450074 pictures 2024-11-19 PF-3450074
1352879-65-2
 US $47.00-136.00 / mg 99.92% 10g TargetMol Chemicals Inc.
  • PF-3450074 pictures
  • PF-3450074
    1352879-65-2
  • US $47.00-136.00 / mg
  • 99.92%
  • TargetMol Chemicals Inc.

PF-3450074 Spectrum

PF-3450074(1352879-65-2)1HNMR

1352879-65-2(PF-3450074)Related Search:

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1of4

2-Methyl-N-[(1S)-2-(methylphenylamino)-2-oxo-1-(phenylmethyl)ethyl]- 1H-indole-3-acetamide PF 3450074 PF-3450074 PF74 1H-Indole-3-acetamide, 2-methyl-N-[(1S)-2-(methylphenylamino)-2-oxo-1-(phenylmethyl)ethyl]- PF74 >=98% (HPLC) (S)-N-Methyl-2-(2-(2-methyl-1H-indol-3-yl)acetamido)-N,3-diphenylpropanamide capsid protein,inhibit,PBMC,PF74,Human immunodeficiency virus,Inhibitor,PF-3450074,PF 3450074,PF 74,HIV,PF3450074 (2S)-N-methyl-2-[2-(2-methyl-1H-indol-3-yl)acetamido]-N,3-diphenylpropanamide PF-3450074, 10 mM in DMSO 1352879-65-2